revised Supporting informationPerali Ramu Sridhar*, Kalapati Seshadri and Gadi Madhusudhan Reddy...

1

SUPPORTING INFORMATION

Stereoselective Synthesis of Sugar Fused β-Disubstituted γ-butyro-lactones: C-Spiro-glycosides from 1,2-Cyclopropane-

-carboxylated Sugars

Perali Ramu Sridhar*, Kalapati Seshadri and Gadi Madhusudhan Reddy

School of Chemistry, University of Hyderabad, Hyderabad-500 046, India

Email : [email protected]

Table of Contents Page No.

General methods 2

General Procedures 2-3

Spectral Data 3-8

Spectras 7-118

Electronic Supplementary Material (ESI) for Chemical CommunicationsThis journal is © The Royal Society of Chemistry 2011

2

General Methods: All reactions are performed in oven-dried apparatus. Reaction

mixtures were stirred magnetically unless otherwise stated. All the products were

characterised by using NMR. Commercial grade solvents were distilled prior to use.

Dichlormethane, dimethyl formamide and methanol were intially dried and stored

over 4 A0 molecular sieves. 1H and 13C NMR spectra were recorded over 500 MHz

or 400 MHz and 125 MHz or 100 MHz respectively. Coupling constants are reported

in Hz. CDCl3 (0.03% TMS) was used for recording NMR spectra.

General Procedures and Data

General experimental procedure for the preparation of 1,2-

cyclopropanecarboxylates:

To a stirred suspension of glucal (1.0 mmol) and Rh2(OAc)4 (0.02 mmol) in

anhydrous CH2Cl2 (2 mL) was added dropwise, over a period of 1 h, a solution of

methyl diazoacetate (3 mmol) in CH2Cl2 (10 mL). After cessation of the nitrogen

evolution (5-10 min), the reaction mixture was concentrated in vacuo and the

remaining residue was purified by silica gel column chromatography (eluent: 10-30%

EtOAc in light petroleum) to give the desired 1,2-cyclopropanecarboxylate adduct.

General experimental procedure for NBS mediated ring opening of 1,2-

cyclopropanecarboxylate:

To a stirred solution of 1,2-cyclopropanecarboxylate (0.5 mmol) in 1,4-dioxane:water

(5 mL (2:1)) was added N-bromosuccinimide (0.6 mmol) and the stirring was

continued until the reaction mixture showed the absence of starting material on TLC.

The reaction mixture was then concentrated to half its volume in vacuo and extracted

with CH2Cl2 (2 x 10 mL). The combined extracts were dried over anhydrous Na2SO4,

filtered and concentrated. Purification by column chromatography over silica gel

using EtOAc:hexane provided the bromohydrin as color less gum in 65-81% yield.

General experimental procedure for the K2CO3 mediated one-pot reaction:

To a stirred solution of bromohydrin (0.25 mmol) in CH3OH (2 mL) under nitrogen

was added K2CO3 (0.50 mmol) at 25 0C. The reaction mixture was stirred for a period

of 6 h. CH3OH was evaporated, and the reaction mixture was diluted with CH2Cl2 (20

mL) and washed with 1% HCl (10 mL) and water (10 mL). The organic layer was


3

dried over anhydrous Na2SO4 and concentrated. Column chromatography of the crude

product with EtOAc : hexane afforded the pure spirocyclic lactol as a color less gum

in 72-92% yield.

General experimental procedure for dehydroxylation:

To a stirred solution of spiro lactol (0.2 mmol) in CH2Cl2 at 0 oC was added triethyl

silane (0.8 mmol) and trifluoroacetic acid (0.4 mmol) dropwise respectively and

continued stirring while allowing the reaction to 25 oC. After completion of reactin (2-

3 h) solvent was evaporated and the crude product was purified by colum

chromatography over silicagel using EtOAc:hexane to afford pure spirolactone in 88-

94% yield.

Compound 20 and Compound 24: 1H NMR

(CDCl3, 400 MHz): δ 7.26-7.43 (m, 10H),

4.79 (s, 2H), 4.60 (s, 2H), 4.09 (s, 1H), 3.97

(d, 1H, J = 6.8 Hz), 3.86 (dd, 1H, J = 5.2 Hz,

J = 6.4 Hz), 3.67 (s, 3H), 3.54 (dd, 1H, J = 3.2 Hz, J = 10.4 Hz), 3.43-3.47 (m, 1H),

2.10 (t, 1H, J = 6.4 Hz), 1.60 (d, 1H, J = 6.4 Hz). 13C NMR (CDCl3, 100 MHz): δ

171.5, 138.0, 137.8, 128.3, 128.2, 128.1, 127.7, 127.6, 127.5, 127.4, 127.3, 73.4, 72.0,

71.2, 70.9, 62.9, 58.3, 51.7, 26.6, 25.4. Low-resolution MS (EI): m/z: 368 (M+).

Compound 33 (major diastereomer): 1H NMR (CDCl3, 400

MHz): δ 7.29-7.39 (m, 10H), 4.68 (d, 1H, J = 12 Hz), 4.60 (d,

1H, J = 12 Hz), 4.58 (d, 1H, J = 12 Hz), 4.51 (d, 1H, J = 12

Hz), 4.01 (dd, 1H, J = 1.6 Hz, J = 7.2 Hz), 3.95 (d, 1H, J = 2

Hz), 3.75 (dd, 1H, J = 1.6 Hz, J = 12 Hz), 3.69 (s, 3H), 3.49-3.50 (m, 1H), 2.30 (dd,

1H, J = 2 Hz, J = 6.4 Hz), 1.93 (dd, 1H, J = 6.4 Hz, J = 7.2 Hz). 13C NMR (CDCl3,

100 MHz): δ 172.5, 137.7, 128.5, 128.4, 127.9, 127.8, 127.7, 74.4, 71.6, 70.9, 70.4,

62.3, 58.7, 51.8, 24.4, 23.9. Low-resolution MS (EI): m/z: 368 (M+).

Compound 9: 1H NMR (CDCl3, 400 MHz): δ 7.26-7.29 (m,

15H), 4.51-4.62 (m, 6H), 4.12-4.17 (m, 2H), 4.04-4.07 (m,

1H), 3.76-3.85 (m, 2H), 3.54-3.69 (m, 4H), 1.99 (ddd, 1H, J =

OOH

BnO OBn

BnO

OH

9

O

BnO

OBn

COOMe O

BnO

OBn

COOMe

20 24

and

O

BnO

OBn

COOMe

33 (major product)


4

3.2 Hz, J = 7.2 Hz, J = 15.2 Hz), 1.89 (ddd, 1H, J = 3.6 Hz, J = 7.2 Hz, J = 15.2 Hz). 13C NMR (CDCl3, 100 MHz): δ 137.8, 137.7, 137.6, 128.5, 128.4, 127.9, 127.9, 127.8,

127.8, 127.7, 127.7, 85.7, 85.7, 83.5, 79.6, 73.4, 72.7, 72.4, 69.6, 66.0, 58.8, 34.7.

Low-resolution MS (EI): m/z: 478 (M+).

Compound 10: 1H NMR (CDCl3, 400 MHz): δ 9.87 (s, 1H),

7.22-7.38 (m, 15H), 4.41-4.58 (m, 7H), 4.10 (d, 1H, J = 1.6

Hz), -4.08 (t, 1H, J = 2 Hz), 2H), 3.56-3.68 (m, 5H), 3.02 (d,

2H, J = 10.8 Hz). 13C NMR (CDCl3, 100 MHz): δ 204.1,

170.6, 137.9, 137.0, 136.9, 128.5, 128.4, 128.3, 128.0, 127.8, 129.7, 127.7, 127.6,

89.5, 84.7, 83.3, 81.5, 73.1, 72.6, 71.4, 71.1, 69.7, 51.9, 38.9. Low-resolution MS

(EI): m/z: 504 (M+).


15H), 4.52-4.64 (m, 5H), 4.45 (d, 1H, J = 12 Hz), 4.34 (d, 1H, J

= 10 Hz), 4.20-4.23 (m, 2H), 4.11 (t, 1H, J = 3.2 Hz), 3.92 (d,

1H, J = 2.8 Hz), 3.50-3.59 (m, 2H), 2.97 (d, 1H, J = 18.4 Hz),

2.69 (d, 1H, J = 18.4 Hz). 13C NMR (CDCl3, 100 MHz): δ 175.1, 137.8, 137.4, 137.0,

128.7, 128.6, 128.4, 128.2, 128.1, 127.8, 129.8, 127.7, 87.2, 84.2, 82.6, 81.9, 75.7,

73.4, 72.0, 70.0, 35.8. Low-resolution MS (EI): m/z: 475 (M++1).


15H), 4.73 (d, 1H, 11.6 Hz), 4.72 (d, 1H, J = 11.6 Hz), 4.63 (d,

1H, J = 11.6 Hz), 4.58 (d, 1H, J 12 Hz), 4.51 (d, 1H, J = 12 Hz),

4. 48 (d, 1H, J = 12 Hz), 4.28 (d, 1H, J = 10 Hz), 4.19-4.23 (m,

1H), 4.14 (t, 1H, J = 3.6 Hz), 4.11 (d, 1H, J = 10 Hz), 3.82 (d, 1H, J = 3.6 Hz), 3.73

(dd, 1H, J = 6.4 Hz, J = 9.2 Hz), 3.61 (dd, 1H, J = 6 Hz, J = 9.6 Hz), 3.26 (d, 1H, J =

18.4 Hz), 2.56 (d, 1H, J = 18.4 Hz). 13C NMR (CDCl3, 100 MHz): δ 176.2, 137.9,

137.6, 136.7, 128.6, 128.4, 127.7, 127.4, 84.6, 80.5, 78.9, 75.8, 75.7, 73.7, 73.5, 72.8,

68.5, 37.4. Low-resolution MS (EI): m/z: 475 (M++1).

Compound 19: 1H NMR (CDCl3, 400 MHz): δ 7.28-7.36 (m, 10H),

4.69 (d, 1H, J = 12 Hz), 4.57 (s, 1H), 4.56 (s, 1H), 4.52 (d, 1H, J =

12 Hz), 4.32 (d, 1H, J = 10 Hz), 4. 18 (d, 1H, J = 10 Hz), 4.11-4.13

O

CHO

BnO OBn

BnO

10

O

OMe

OO

BnO OBn

BnO

O

11

OO

BnO OBn

BnO

O

15


5

(m, 1H), 3.89 (d, 1H, J = 2.8 Hz), 3.77 (dd, 1H, J = 2.8 Hz, J = 4 Hz), 2.99 (d, 1H, J

= 18 Hz), 2.64 (d, 1H, J = 18 Hz), 1.33 (d, 3H, J = 6.4 Hz). 13C NMR (CDCl3, 100

MHz): δ 175.0, 137.3, 137.0, 128.7, 128.6, 128.2, 128.1, 127.8, 129.6, 127.5, 87.4,

86.9, 84.9, 78.8, 75.9, 72.2, 72.1, 36.2, 20.2. Low-resolution MS (EI): m/z: 369

(M++1).

Compound 23 and Compound 27: 1H NMR

(CDCl3, 400 MHz): δ 7.31-7.38 (m, 10H), 4.77 (d,

1H, J = 12 Hz), 4.64 (d, 1H, J = 12 Hz), 4.56 (d,

1H, J = 12 Hz), 4.51 (d, 1H, J = 12 Hz), 4.24 (d,

1H, J = 10 Hz), 4.16 (d, 1H, J = 10 Hz), 4.07 (ddd, 1H, J = 1.2 Hz, J = 5.6 Hz, J =

10 Hz), 4.02 (d, 1H, J = 1.2 Hz), 3.98 (dd, 1H, J = 4 Hz, J = 10.8 Hz), 3.72 (d, 1H, J

= 4.4 Hz), 3.22 (d, 1H, J = 18.4 Hz), 2.51 (d, 1H, J = 18.4 Hz). 13C NMR (CDCl3,

100 MHz): δ 176.0, 137.5, 136.9, 128.6, 128.5, 128.3, 127.9, 129.8, 127.6, 84.7, 79.4,

75.3, 74.9, 72.5, 71.8, 70.6, 36.0. Low-resolution MS (EI): m/z: 355 (M++1).

Compound 32 (major Diastereomer): 1H NMR (CDCl3, 400

MHz): δ 7.28-7.42 (m, 10H), 4.69 (d, 1H, J = 11.2 Hz), 4.57 (s,

1H), 4.56 (s, 1H), 4.46 (d, 1H, J = 11.2 Hz), 4.35 (d, 1H, J = 10

Hz), 4.21 (d, 1H, J = 10 Hz), 4.16 (dd, 1H, J = 3.6 Hz, J = 7.6

Hz), 4.12 (dd, 1H, J = 2.0 Hz, J = 3.6 Hz), 3.89 (d, 1H, J = 2.0 Hz), 3.74-3.77 (m,

1H), 3.64-3.67 (m, 1H), 2.95 (d, 1H, J = 18.2 Hz), 2.67 (d, 1H, J = 18.2 Hz), 2.06 (bs,

1H). 13C NMR (CDCl3, 100 MHz): δ 174.7, 137.0, 136.6, 128.8, 128.7, 128.4, 128.3,

128.0, 127.7, 87.8, 83.9, 89.9, 82.1, 75.3, 72.4, 72.0, 62.8, 35.7. Low-resolution MS

(EI): m/z: 384 (M+).

Compound 36 (major diastereomer): 1H NMR (CDCl3, 400 MHz):

δ 7.32-7.44 (m, 10H), 4.71 (d, 1H, J = 12 Hz), 4.58 (d, 1H, J =

11.6 Hz), 4.56 (d, 1H, J = 12 Hz), 4.51(d, 1H, J = 12 Hz), 4.35 (d,

1H, J = 6.0 Hz), 4.25 (d, 1H, J = 6.0 Hz), 4.15-4.18 (m, 1H), 4.09

(dd, 1H, J = 4.4 Hz, J = 10.0 Hz), 4.00 (bs, 1H), 3.92 (bs, 1H), 3.00 (d, 1H, J = 18.0

Hz), 2.61 (d, 1H, J = 18.0 Hz). 13C NMR (CDCl3, 100 MHz): δ 175.0, 137.2, 137.0,

128.7, 128.6, 128.3, 127.8, 127.6, 87.3, 84.2, 81.7, 76.0, 72.4, 71.8, 70.9, 35.1. Low-

resolution MS (EI): m/z: 355 (M++1).

OO

BnO OBn

HO

O

32

OO

BnO OBn

O

23

OO

BnO OBn

O

27

and


6

Compound 38: 1H NMR (CDCl3, 500 MHz): δ 6.97 (dd, 1H, J

= 1.5 Hz, J = 2.5 Hz), 4.45 (s, 1H), 3.91 (dd, 1H, J = 4.5 Hz, J

= 11.5 Hz), 3.70-3.74 (m, 4H), 3.47-3.57 (m, 2H), 2.81 (dt, 1H,

J = 3.5 Hz, J = 19.0 Hz), 2.15 (d, 1H, J = 14.5 Hz), 1.90-1.95

(dt, 1H, J = 4.5 Hz, J = 13 Hz), 1.70-1.77 (m, 1H), 1.36 (d, 1H, J = 12 Hz). 13C NMR

(CDCl3, 125 MHz): δ 165.6, 164.4, 138.4, 129.0, 74.7, 69.3, 68.0, 51.7, 31.8, 28.2,

19.0. Low-resolution MS (EI): m/z: 226 (M+).


10H), 6.97 (dd, 1H, J = 6.8 Hz, J = 16.4 Hz), 6.09 (d, 1H, J

= 15.6 Hz), 4.62 (d, 1H, J = 11.6 Hz), 4.52 (s, 2H), 4.40 (d,

1H, J = 11.6 Hz), 4.09 (t, 1H, J = 6 Hz), 3.91 (m, 1H), 3.76

(s, 3H), 3.59 (d, 2H, J = 4.8 Hz), 2.43 (bs, 1H). 13C NMR (CDCl3, 100 MHz): δ 166.2,

144.9, 137.7, 137.6, 128.4, 127.8, 123.8, 78.6, 73.5, 72.2, 71.6, 70.3, 51.7. Low-

resolution MS (EI): m/z: 357 (M++1).

Compound 48 (major diastereomer): 1H NMR (CDCl3, 400

MHz): δ 5.49 (bs, 1H), 4.43-4.45 (m, 1H), 4.18 (dd, 1H, J = 6.0

Hz, J = 8.4 Hz), 3.88 (dd, 1H, J = 2 Hz, J = 11.2 Hz), 3.80 (dd,

1H, J = 4.0 Hz, J = 11.2 Hz), 3.62-3.65 (m, 1H), 3.02 (d, 1H, J =

18.0 Hz), 2.65 (d, 1H, J = 18 Hz), 2.14-2.21 (m, 2H), 1.37 (s, 3H),

1.27 (s, 3H), 0.93 (s, 9H), 0.10 (s, 6H). 13C NMR (CDCl3, 100 MHz): δ 171.7, 109.5,

102.2, 76.0, 73.7, 70.0, 69.5, 62.6, 40.4, 31.6, 27.7, 25.8, 25.3, 18.3, -5.2, -5.3. Low-

resolution MS (EI): m/z: 388 (M+).

O

O O

COOMe

38

O O

O

OHOO

TBSO

48


7

1 HNMR,400MHz,CDCl 3

O

BnO

OBn

BnO

COOMe

OH

Br

7


8

13CNMR,100MHz,CDCl 3

O

BnO

OBn

BnO

COOMe

OH

Br

7


9

1HNMR,400MHz,CDCl 3

OO

BnO

OBn

BnO

O OH

8


10

13 CNMR,100MHz,CDCl 3

OO

BnO

OBn

BnO

O

OH

8


11

13 CDEPT,100MHz,CDCl 3

OO

BnO

OBn

BnO

O OH

8


12

1HNMR,400MHz,CDCl 3

OOH

BnO

OBn

BnO

OH

9


13


OOH

BnO

OBn

BnO

OH

9


14


OOH

BnO

OBn

BnO

OH

9


15

ppm

2.0

2.5

3.0

3.5

4.0

4.5

5.0

ppm

2.0

2.5

3.0

3.5

4.0

4.5

5.0


16

NOESY,400MHz,CDCl 3

OOH

BnO

OBn

BnO

OH

9


17


O

CHO

BnO

OBn

BnO

10

O

OMe


18


O

CHO

BnO

OBn

BnO

10

O

OMe


19


O

CHO

BnO

OBn

BnO

10

O

OMe


20

1HNMR,400MHz,CDCl 3

OO

BnO

OBn

BnO

O

11


21


OO

BnO

OBn

BnO

O

11


22


OO

BnO

OBn

BnO

O

11


23


24

NOESY,400MHz,CDCl 3

OO

BnO

OBn

BnO

O

11


25

O

BnO

OBn

BnO

COOMe

OH

Br


13


26

O

BnO

OBn

BnO

COOMe

OH

Br


13


27

1HNMR,400MHz,CDCl 3

OO

BnO

OBn

BnO

O OH

14


28


OO

BnO

OBn

BnO

O

OH

14


29


OO

BnO

OBn

BnO

O OH

14


30

1HNMR,400MHz,CDCl 3

OO

BnO

OBn

BnO

O

15


31


OO

BnO

OBn

BnO

O

15


32


OO

BnO

OBn

BnO

O

15


33

ppm

2.4

2.6

2.8

3.0

3.2

3.4

3.6

3.8

4.0

4.2

4.4

4.6

4.8

5.0

ppm

2.4

2.6

2.8

3.0

3.2

3.4

3.6

3.8

4.0

4.2

4.4

4.6

4.8

5.0


34

ppm

2.4

2.6

2.8

3.0

3.2

3.4

3.6

3.8

4.0

4.2

4.4

4.6

4.8

5.0

ppm

2.4

2.6

2.8

3.0

3.2

3.4

3.6

3.8

4.0

4.2

4.4

4.6

4.8

5.0

NOESY,400MHz,CDCl 3

OO

BnO

OBn

BnO

O

15


35

1HNMR,400MHz,CDCl 3

17

O

BnO

OBn

COOMe

OH

Br


36


17

O

BnO

OBn

COOMe

OH

Br


37

1HNMR,400MHz,CDCl 3

OO

BnO

OBn

O OH

18


38


OO

BnO

OBn

O OH

18


39


OO

BnO

OBn

O OH

18


40

1HNMR,400MHz,CDCl 3

OO

BnO

OBn

O

19


41


OO

BnO

OBn

O

19


42


OO

BnO

OBn

O

19


43

ppm

1.5

2.0

2.5

3.0

3.5

4.0

4.5

5.0

ppm

1.5

2.0

2.5

3.0

3.5

4.0

4.5

5.0


44

ppm

1.5

2.0

2.5

3.0

3.5

4.0

4.5

5.0

ppm

1.0

1.5

2.0

2.5

3.0

3.5

4.0

4.5

5.0

NOESY,400MHz,CDCl 3

OO

BnO

OBn

O

19


45

1HNMR,400MHz,CDCl 3

O

BnO

OBn

COOMe

20


46


O

BnO

OBn

COOMe

20


47


O

BnO

OBn

COOMe

20


48

1HNMR,400MHz,CDCl 3

O

BnO

OBn

COOMe

OH

Br

21

H


49


O

BnO

OBn

COOMe

OH

Br

21

H


50


O

BnO

OBn

COOMe

OH

Br

21

H


51

1HNMR,400MHz,CDCl 3

OO

BnO

OBn

O OH

22


52


OO

BnO

OBn

O OH

22


53


OO

BnO

OBn

O OH

22


54


OO

BnO

OBn

O

23


55


56


57

ppm

2.6

2.8

3.0

3.2

3.4

3.6

3.8

4.0

4.2

4.4

4.6

4.8

5.0

ppm

2.6

2.8

3.0

3.2

3.4

3.6

3.8

4.0

4.2

4.4

4.6

4.8

5.0

1 H-1 HCOSY,500MHz,CDCl 3

OO

BnO

OBn

O

23


58

ppm

2.6

2.8

3.0

3.2

3.4

3.6

3.8

4.0

4.2

4.4

4.6

4.8

5.0

ppm

2.6

2.8

3.0

3.2

3.4

3.6

3.8

4.0

4.2

4.4

4.6

4.8

5.0


59

1HNMR,400MHz,CDCl 3

O

BnO

OBn

COOMe

24


60


O

BnO

OBn

COOMe

24


61


O

BnO

OBn

COOMe

24


62


O

BnO

OBn

COOMe

OH

BrH

25


63


64

1HNMR,400MHz,CDCl 3

OO

BnO

OBn

O OH

26


65


OO

BnO

OBn

O OH

26


66

1HNMR,400MHz,CDCl 3

OO

BnO

OBn

O

27


67


OO

BnO

OBn

O

27


68

ppm

2.6

2.8

3.0

3.2

3.4

3.6

3.8

4.0

4.2

4.4

4.6

4.8

5.0

ppm

2.6

2.8

3.0

3.2

3.4

3.6

3.8

4.0

4.2

4.4

4.6

4.8

5.0


69

NOESY,400MHz,CDCl 3

OO

BnO

OBn

O

27


70

O

BnO

OBn

HO

COOMe

OH

Br

1HNMR,400MHz,CDCl 3

29


71

O

BnO

OBn

HO

COOMe

OH

Br


29


72

O

BnO

OBn

TBSO

COOMe

OH

Br

1HNMR,400MHz,CDCl 3

30


73

O

BnO

OBn

TBSO

COOMe

OH

Br


30


74

1HNMR,400MHz,CDCl 3

OO

BnO

OBn

TBSO

O

OH

31


75


OO

BnO

OBn

TBSO

O

OH

31


76


OO

BnO

OBn

O

32

HO


77


78

13CDEPT,100MHZ,CDCl 3

OO

BnO

OBn

O

32

HO


79

ppm

2.6

2.8

3.0

3.2

3.4

3.6

3.8

4.0

4.2

4.4

4.6

4.8

ppm

2.6

2.8

3.0

3.2

3.4

3.6

3.8

4.0

4.2

4.4

4.6

4.8


80

ppm

2.6

2.8

3.0

3.2

3.4

3.6

3.8

4.0

4.2

4.4

4.6

4.8

5.0

ppm

2.6

2.8

3.0

3.2

3.4

3.6

3.8

4.0

4.2

4.4

4.6

4.8

5.0


81


82

200

190

180

170

160

150

140

130

120

110

100

90

80

70

60

50

40

30

20

10

0ppm

23.9924.4825.7026.03

51.8251.9458.7662.3062.3566.0170.3970.8970.9371.6172.7974.4275.4076.5376.8077.1277.3277.44

127.69127.71127.75127.80127.84127.87127.92128.45128.52128.55129.74137.79137.81138.18

171.84172.56


83

20

30

40

50

60

70

80

90

100

110

120

130

140

150

160

ppm

23.9924.4825.7026.03

51.8251.9558.7662.3062.3666.0170.3870.8970.9371.6072.7974.4175.4076.52

127.69127.72127.76127.80127.84127.87127.92128.45128.52128.55


84


85


86


87


88


89


90


91


92

ppm

2.6

2.8

3.0

3.2

3.4

3.6

3.8

4.0

4.2

4.4

4.6

4.8

5.0

ppm

2.6

2.8

3.0

3.2

3.4

3.6

3.8

4.0

4.2

4.4

4.6

4.8

5.0


93

ppm

2.6

2.8

3.0

3.2

3.4

3.6

3.8

4.0

4.2

4.4

4.6

4.8

5.0

ppm

2.6

2.8

3.0

3.2

3.4

3.6

3.8

4.0

4.2

4.4

4.6

4.8

5.0


94


O

COOMe

O

37


95


O

COOMe

O

37


96


97


98


99


100


101


102


103


104


105


106


107

13 CNMR,100MHZ,CDCl 3

BnO

COOMe

OH OBn

41


108


109


110


O

O

O

TBSO

COOMe

45


111


112


113


114


115


116


117


OOO OH

OO

TBSO

48


118


revised Supporting informationPerali Ramu Sridhar*, Kalapati Seshadri and Gadi Madhusudhan Reddy...

Documents

Transcript of revised Supporting informationPerali Ramu Sridhar*, Kalapati Seshadri and Gadi Madhusudhan Reddy...