FOSFODIESTERASAS

Carol Andrea Casallas

Residente Farmacología Clínica

GENERALIDADES

1886 1958 1963 1970-1984 1995 2005

AMPc GMPc

Boswell-Smith V, et al. Phosphodiesterase inhibitors. British Journal of Pharmacology (2006) 147, S252–S257Vezzosi D, et al. Phosphodiesterases in endocrine physiology and disease. European Journal of Endocrinology (2011) 165 177–188

EFECTOS

Adenil Ciclasa

α β γ

AMPcGMPc

5’GMP

5’AMP

PKA

Enzimas EfectorasCanales Iónicos

Transcripción Genética Diferenciación Proliferación

Boswell-Smith V, et al. Phosphodiesterase inhibitors. British Journal of Pharmacology (2006) 147, S252–S257Vezzosi D, et al. Phosphodiesterases in endocrine physiology and disease. European Journal of Endocrinology (2011) 165 177–188

EFECTOS

Son 11Familias:• 3 Selectivos AMPc (4,7,8).• 3 Selectivos GMPc (5,6,9).• 5 Ambos (1,2,3,10,11)

Vasodialtación.BroncodilataciónAntiagregaciónInotropico (+)MilrinoneCilostazol

Cel. InflamatoriaBroncodialtaciónPDE4 (a4)- PDE7TeofilinaRoflumilast

VasodilatadorPentoxifilinaSildenafil

PDE 3 PDE 4 PDE 5

Boswell-Smith V, et al. Phosphodiesterase inhibitors. British Journal of Pharmacology (2006) 147, S252–S257Vezzosi D, et al. Phosphodiesterases in endocrine physiology and disease. European Journal of Endocrinology (2011) 165 177–188

Boswell-Smith V, et al. Phosphodiesterase inhibitors. British Journal of Pharmacology (2006) 147, S252–S257Vezzosi D, et al. Phosphodiesterases in endocrine physiology and disease. European Journal of Endocrinology (2011) 165 177–188

Boswell-Smith V, et al. Phosphodiesterase inhibitors. British Journal of Pharmacology (2006) 147, S252–S257Vezzosi D, et al. Phosphodiesterases in endocrine physiology and disease. European Journal of Endocrinology (2011) 165 177–188

Boswell-Smith V, et al. Phosphodiesterase inhibitors. British Journal of Pharmacology (2006) 147, S252–S257Vezzosi D, et al. Phosphodiesterases in endocrine physiology and disease. European Journal of Endocrinology (2011) 165 177–188

Boswell-Smith V, et al. Phosphodiesterase inhibitors. British Journal of Pharmacology (2006) 147, S252–S257Vezzosi D, et al. Phosphodiesterases in endocrine physiology and disease. European Journal of Endocrinology (2011) 165 177–188

GRACIAS!!!!