Supplemental Figure 1

Frozen FFPE0

2

4

6

8

10

12

14

16

18

20

22

IPMN samples

miR

-21

exp

ress

ion

(2

-Δ C

t )

Frozen invasive IPMN

Frozen non-invasive IPMNFFPE invasive IPMN

FFPE non-invasive IPMNP=0.10

A

B

C

Supplemental Figure 2

Den

sity

(%)

Den

sity

(%)

Den

sity

(%)

microRNA expression values (2-ΔCt)0.0 5 10 15 20 25

0.0

20

40

60

0.0 5 10 15 20

0.0

5

10

30

15

20

25

0.0 5 10 15 20 25 30

0.0

20

40

60

80

Supplemental Figure 3

A

B

C

P=0.074

P=0.084

Cu

mu

lati

ve P

erce

nta

ge

Cu

mu

lati

ve P

erce

nta

ge

DFS (Time, months)

OS (Time, months)

0.0 25 50 75 100 125

0.0

20

40

60

80

100

0.0 25 50 75 100 125

0.0

20

40

60

80

100

miR-155miR-101

miR-21

B

HG

FE

DC

A

Supplemental Figure 4

Supplemental Figure 5