Supplemental Figure 1 - Journal of Biological Chemistry€¦ · Supplemental Figure 1. GATA6 is...

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Supplemental Figure 1 siRNA Control + Ad.βgal siRNA GATA6 + Ad.βgal siRNA GATA6 + Ad.GATA6

Transcript of Supplemental Figure 1 - Journal of Biological Chemistry€¦ · Supplemental Figure 1. GATA6 is...

Page 1: Supplemental Figure 1 - Journal of Biological Chemistry€¦ · Supplemental Figure 1. GATA6 is essential for endothelial vessel-like structure formation. Representative images of

Supplemental Figure 1

siRNA Control + Ad.βgal siRNA GATA6 + Ad.βgal siRNA GATA6 + Ad.GATA6

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Supplemental Figure 2

siRNA Control + Ad.βgal siRNA GATA6 + Ad.βgal siRNA GATA6 + Ad.GATA6

7AA

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AnnexinV AnnexinV AnnexinV

0.6%

7.0% 10.0%

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7.0%

0.7%72.0% 65.0% 73.0%

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SUPPLEMENTAL FIGURE LEGENDS Supplemental Figure 1. GATA6 is essential for endothelial vessel-like structure formation. Representative images of vessel-like structure formation on Matrigel in HUVECs when treated with a control or a GATA6 specific siRNA, and infected with a GATA6 (Ad.GATA6) or β-galactosidase (Ad.βgal, as control) expressing adenoviral vector. Note that reintroduction of GATA6 (by adenoviral vector) into siRNA GATA6 treated cells rescued the ability of endothelial cells to form vessel-like structures. HUVECs were visualized using an Axiovert 200M microscope (Carl Zeiss) with a 5x/ 0.12 lense (Carl Zeiss). Supplemental Figure 2. GATA6 is essential for endothelial cell survival. Flow cytometric analysis of HUVECs (under growth factor withdrawal) stained with annexin-V and 7AAD, treated with a control or a GATA6 specific siRNA, and infected with a GATA6 (Ad.GATA6) or β-galactosidase (Ad.βgal, as control) expressing adenoviral vector. The numbers in the lower-right quadrant of the plots indicate the number of annexin-V positive cells (early apoptotic cells), whereas in the upper-right quadrant the number of cells staining positive for both annexin-V and 7AAD (late apoptotic/necrotic cells) is indicated. The number in the lower left quadrant indicates the amount of viable cells (negative for both annexin-V and 7AAD). Data from a representative experiment are shown; the experiment was repeated with similar results. Note that reintroduction of GATA6 (by adenoviral vector) into siRNA GATA6 treated cells reduced cell death and increased the amount of viable cells to levels observed in siRNA control/Ad.βgal treated HUVECs.

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Supplemental Table 1: Real-Time PCR Primers specific for human mRNA, listed from 5´ to 3´end. GATA6 forward TCTACAGCAAGATGAACGGCCTCA GATA6 reverse TCTGCGCCATAAGGTGGTAGTTGT VEGFA forward ACACATTGTTGGAAGAAGCAGCCC VEGFA reverse AGGAAGGTCAACCACTCACACACAANGPT2 forward AGGACACACCACGAATGGCATCTAANGPT2 reverse TGAATAATTGTCCACCCGCCTCCT TIE2 forward GAACTGCACACGTTTGGCAGAACT TIE2 reverse ACCTAAGCTTACAATCTGGCCCGT NOS3 forward TTTAAAGAAGTGGCCAACGCCGTG NOS3 reverse AGCCATACAGGATTGTCGCCTTCA PECAM1 forward TTGAGACCAGCCTGATGAAACCCT PECAM1 reverse TCCGTTTCCTGGGTTCAAGCGATA EDN1 forward TCTTCACTGGCTTCCATCAGTGGT EDN1 reverse TGTGTGTTTCTGCTGAGAGGTCCA PDGFA forward GCTTTATTGCCAGTGTGCGGTCTT PDGFA reverse TGCACTGTCTCTTTGTTCTCCCGA TGFβ1 forward ACAATTCCTGGCGATACCTCAGCA TGFβ1 reverse CGCTAAGGCGAAAGCCCTCAATTT HIF1A forward TTGGCAGCAACGACACAGAAACTGHIF1A reverse TTGAGTGCAGGGTCAGCACTACTT AKT1 forward AGCACGTGTACGAGAAGAAGCTCAAKT1 reverse ATCTTGGTCAGGTGGTGTGATGGT FGFR1 forward ACATCGAGGTGAATGGGAGCAAGAFGFR1 reverse AAGCACCTCCATCTCTTTGTCGGT TGFβ2 forward TGCAGAGAGATGTTTGCACCATGC TGFβ2 reverse TGACAGGCAAGTAGCTGATCCCAA SMAD2 forward TCTGCTCGAGAAGCCAGAATGTGT SMAD2 reverse TCAGTCTGCATCAGGACACCCAAT HIF3α forward TTGCCCAGGCTGGAGTATAATGGT HIF3α reverse TACACAAAGGTAGCCGGATGTGGT TFPI2 forward TACTGGCTGTGGAGGGAATGACAA TFPI2 reverse TCCGGATTCTACTGGCAAAGCGAA GHR forward TATGCCCAGGTGAGCGACATTACA GHR reverse ATTTCCGGGTGCATGTCACATTGG IL-11 forward TCCCAAAGTGCTGGGATTACAGGT IL-11 reverse TCACAGGGTGACTTGTGGAACCTT FN1 forward AAACTTGCATCTGGAGGCAAACCC FN1 reverse AGCTCTGATCAGCATGGACCACTT SERPINE1 forward AATGTGTCATTTCCGGCTGCTGTG SERPINE1 reverse ACATCCATCTTTGTGCCCTACCCT ID1 forward AGGTAAACGTGCTGCTCTACGACA ID1 reverse TGTAGTCGATGACGTGCTGGAGAA GAPDH forward TCGACAGTCAGCCGCATCTTCTTT GAPDH reverse ACCAAATCCGTTGACTCCGACCTT

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Supplemental Table 2: Results of the Agilent Microarray (human gene expression 4x44k v2 kit) comparing RNA expression between HUVECs treated with siRNA control or GATA6 specific siRNA.

ProbeName

Fold change([siControl]

vs [siGATA6]) Regulation([siControl]

vs [siGATA6]) Common name GeneSymbol A_24_P151920 2,0123644 up NM_014573 TMEM97 A_24_P131173 2,144962 up NM_024709 C1orf115 A_23_P107597 2,5234766 up NM_005603 ATP8B1 A_24_P305467 2,2102811 up AK024670 AK024670 A_23_P146783 2,3319898 up NM_004543 NEB A_23_P315364 2,5394235 up NM_002089 CXCL2 A_23_P125771 2,0939817 up NM_005334 HCFC1 A_23_P92842 3,3360856 down NM_016103 SAR1B A_23_P149998 2,4357417 up NM_022129 PBLD A_23_P81219 2,1524239 up NM_016619 PLAC8 A_23_P110253 4,347607 down NM_000222 KIT A_23_P53623 2,9486587 up NM_002560 P2RX4 A_23_P375147 2,2193348 down ENST00000373670 ENST00000373670A_24_P208909 2,65035 down NM_015271 TRIM2 A_24_P942017 2,3821683 up AK075204 FLJ90723 A_32_P223777 3,9172902 down ENST00000381298 ENST00000381298A_24_P42527 2,853699 down NM_004866 SCAMP1 A_23_P31041 3,2814865 up NM_013262 MYLIP A_23_P82402 3,2832239 down NM_138426 GLCCI1 A_23_P167276 3,5237231 down NM_001040202 PAQR3 A_23_P86470 3,3808765 up NM_003956 CH25H A_24_P384969 6,1442614 up BC015977 BC015977 A_24_P418250 2,5740502 up ENST00000325900 ENST00000325900A_24_P500771 2,4257333 up AL049782 CG012 A_23_P131846 2,5926642 down NM_005985 SNAI1 A_23_P152995 2,7068663 up NM_001045 SLC6A4 A_24_P355246 2,9401124 down ENST00000376752 ENST00000376752A_23_P210100 10,510027 up NM_019885 CYP26B1 A_23_P24104 3,226498 down NM_002658 PLAU A_23_P312358 2,6425908 up NM_152751 C10orf30 A_23_P37778 2,280115 down NM_013241 FHOD1 A_23_P101342 2,5442593 up NM_032885 ATG4D A_24_P314451 2,015939 up NM_019863 F8 A_23_P20864 2,716228 down NM_012098 ANGPTL2 A_23_P57277 2,2231405 up NM_020152 C21orf7 A_23_P125253 2,601386 up NM_001290 LDB2 A_32_P56497 6,208674 up AL536879 AL536879 A_23_P41227 2,0512953 down NM_001627 ALCAM A_24_P933319 2,8326979 down ENST00000371655 RAB3B A_23_P111132 2,9732103 down NM_005345 HSPA1A A_23_P341418 2,0064602 down AK098818 ZDHHC20 A_23_P85460 2,4424226 up NM_001262 CDKN2C A_23_P121396 2,2831283 up NM_145261 DNAJC19 A_32_P96838 3,214062 up AF119911 AF119911 A_23_P82523 2,8424282 up NM_000927 ABCB1 A_23_P47616 2,0618877 down NM_004476 FOLH1

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A_24_P586390 2,1965935 up AK123446 AK123446 A_24_P861099 2,7398343 down AK094718 FLJ22536 A_23_P65320 3,047227 up NM_002498 NEK3 A_23_P252740 2,0242374 up NM_024094 DCC1 A_32_P9753 2,0009918 down BC024020 TMEM49 A_24_P206776 4,0953903 down NM_001885 CRYAB A_23_P41674 2,1614301 down NM_152407 GRPEL2 A_24_P29733 2,646053 down NM_012395 PFTK1 A_23_P368484 2,4032743 up NM_207387 C17orf76 A_23_P86230 2,0955617 up NM_012333 MYCBP A_23_P6481 2,046206 up NM_015088 TNRC6B A_24_P133253 4,539432 down NM_000899 KITLG A_23_P201979 2,671783 down NM_183013 CREM A_23_P205489 2,5822074 up NM_182728 SLC7A8 A_24_P798431 2,3119733 up A_24_P798431 A_24_P798431 A_23_P418204 2,0219917 down BC006258 ZNF251 A_23_P43484 2,1099 up NM_058197 CDKN2A A_24_P288722 2,424704 down NM_003688 CASK A_24_P294233 2,04482 up NM_014905 GLS A_23_P57089 3,1012435 down NM_020182 TMEPAI A_24_P592570 4,248352 up THC2507877 THC2507877 A_23_P62881 3,0930197 up NM_032291 SGIP1 A_23_P419714 5,0673394 down NM_152322 BTBD11 A_32_P62571 2,620739 up NM_005105 RBM8A A_24_P157926 2,3654988 up NM_006290 TNFAIP3 A_24_P233560 2,517761 down A_24_P233560 A_24_P233560 A_32_P11969 3,3859518 up THC2694800 THC2694800 A_32_P46351 3,1728837 up A_32_P46351 A_32_P46351 A_24_P930337 3,6349306 up THC2503773 THC2503773 A_23_P398566 3,4995582 down NM_173198 NR4A3 A_24_P88554 2,5253844 up NM_003846 PEX11B A_23_P87879 3,8281069 down NM_001781 CD69 A_24_P131622 2,0936081 up NM_007177 FAM107A A_23_P72096 2,7846124 up NM_000575 IL1A A_32_P33821 2,1967537 down NM_001048249 DKFZP686E2158 A_32_P80016 4,90499 up THC2579650 THC2579650 A_24_P124325 2,3880558 down CR749800 IKZF5 A_23_P1691 3,7744837 down NM_002421 MMP1 A_23_P75741 2,2512925 up NM_198183 UBE2L6 A_23_P82868 2,407203 down NM_000930 PLAT A_23_P64173 3,2066681 up NM_001017534 COP1 A_32_P183970 5,555642 down ENST00000344320 LOC643338 A_32_P232851 4,947286 up THC2645586 THC2645586 A_23_P209879 2,2584755 down AK128731 ATF2 A_23_P170719 3,325283 down A_23_P170719 A_23_P170719 A_23_P151120 3,4694903 up NM_032489 ACRBP A_23_P364504 3,9698737 down ENST00000357303 ENST00000357303A_23_P216215 2,103769 up NM_014637 MTFR1 A_23_P215060 3,0727272 down NM_005397 PODXL A_23_P110791 5,6357903 down NM_005211 CSF1R A_23_P37685 2,06532 down NM_024600 C16orf30 A_23_P92410 2,1008184 up NM_004346 CASP3 A_23_P128263 8,882095 down NM_005039 PRB1 A_23_P120883 3,0299795 down NM_002133 HMOX1 A_23_P395321 6,2060256 up A_23_P395321 A_23_P395321 A_23_P388433 4,1788487 up AK025703 LOC401152

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A_23_P420442 2,3461995 down NM_153618 SEMA6D A_24_P799048 2,326782 up AX721193 AX721193 A_32_P181107 3,148009 up THC2596018 THC2596018 A_23_P112874 7,4645505 up NM_004466 GPC5 A_24_P359205 2,1253738 down BC010094 PIGQ A_32_P119007 5,486105 up NM_012291 ESPL1 A_24_P148503 3,8177874 up NM_003468 FZD5 A_23_P140821 4,6020007 up NM_016948 PARD6A A_24_P859032 3,328491 down THC2660977 THC2660977 A_24_P274987 2,0675783 down NM_003692 TMEFF1 A_24_P277657 2,2467654 up NM_006877 GMPR A_23_P404091 2,4247088 down NM_152407 GRPEL2 A_23_P324523 2,4194157 down NM_153208 IQCK A_32_P41153 2,1861758 up BM929882 BM929882 A_24_P251841 2,3438704 down NM_030648 SETD7 A_24_P391987 4,0443897 up NM_001001701 LOC401152 A_23_P44836 5,0302525 down NM_022908 NT5DC2 A_24_P149124 2,536122 down NM_004772 C5orf13 A_23_P421011 3,2935433 up NM_030929 KAZALD1 A_23_P122924 2,3729436 down NM_002192 INHBA A_24_P79054 2,5683508 down NM_000660 TGFB1 A_24_P46093 2,7561011 up NM_003043 SLC6A6 A_24_P14260 2,1600196 up NM_014959 CARD8 A_32_P27135 2,1128116 down BX538139 BX538139 A_24_P248053 2,531352 down NM_052963 TOP1MT A_23_P372925 2,2058184 down NM_033426 KIAA1737 A_24_P80338 2,2325594 up NM_003157 NEK4 A_24_P254278 2,0804126 up NM_203327 SLC23A2 A_32_P110820 2,3492959 up THC2662255 THC2662255 A_24_P416177 2,2762756 down NM_001114 ADCY7 A_23_P46356 3,4485793 up NM_024575 TNFAIP8L2 A_23_P11859 2,34336 up NM_016371 HSD17B7 A_23_P118042 4,8484015 down NM_018296 LRRC36 A_24_P250922 3,812377 down NM_000963 PTGS2 A_24_P261083 3,1400466 down NM_004337 OSGIN2 A_23_P78405 2,095007 down NM_006033 LIPG A_23_P419696 3,8098607 down NM_144586 LYPD1 A_32_P50655 3,1346087 down THC2637707 THC2637707 A_23_P23829 3,495731 up NM_001773 CD34 A_23_P423926 2,1433456 down NM_198935 SS18L1 A_23_P120227 7,860531 down NM_030915 LBH A_23_P253451 5,797798 up NM_020949 SLC7A14 A_23_P134464 3,2701628 up NM_004279 PMPCB A_23_P38106 2,4307969 down NM_021972 SPHK1 A_23_P43810 2,9386652 down NM_206943 LTBP1 A_24_P916614 3,0034692 down NM_005156 ROD1 A_24_P105933 11,235858 up NM_004624 VIPR1 A_23_P25121 2,3212216 down NM_016594 FKBP11 A_23_P215461 3,185741 up NM_002314 LIMK1 A_24_P450596 2,1788301 down CR627133 LOC342892 A_23_P134100 2,4130454 up NM_024518 ULBP3 A_32_P103678 2,1788363 up THC2729899 THC2729899 A_32_P142943 2,1618483 up THC2633491 THC2633491 A_24_P80776 2,741913 up AK129879 AK129879 A_32_P79366 2,3409934 up NM_014282 HABP4 A_23_P129144 3,4825492 up NM_001018100 Gcom1

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A_23_P145995 2,8693757 down NM_005302 GPR37 A_23_P16047 2,0086818 down NM_005282 GPR4 A_23_P201758 2,1457088 up NM_002389 CD46 A_23_P94754 3,6574712 down NM_005118 TNFSF15 A_24_P820372 3,0466173 down THC2740750 THC2740750 A_23_P256487 2,0628448 down ENST00000381577 CD274 A_23_P202978 8,9180975 up NM_033292 CASP1 A_23_P39550 5,947662 up NM_030923 TMEM163 A_24_P46377 3,029303 down ENST00000231198 THG1L A_24_P941946 2,4057307 up AK022881 C20orf74 A_24_P759477 3,4162464 down NM_002214 ITGB8 A_23_P90601 4,589584 down NM_182915 STEAP3 A_23_P201837 2,534145 up AF031469 MR1 A_32_P64716 2,009371 up BC035106 BC035106 A_23_P91334 2,5312407 down NM_052970 HSPA12B A_23_P205553 3,5158567 up NM_182910 SYNE2 A_23_P14515 2,1937022 up NM_152331 ACOT4 A_23_P348146 2,6174667 up NM_144595 SLAIN1 A_32_P146844 2,1837504 up THC2639689 THC2639689 A_23_P134125 5,397868 up NM_005923 MAP3K5 A_23_P47885 2,044643 up NM_153377 LRIG3 A_23_P111240 2,1391063 up NM_014721 PHACTR2 A_23_P374104 2,6656473 down NM_012098 ANGPTL2 A_24_P745883 3,0865817 down A_24_P745883 A_24_P745883 A_23_P36458 2,115408 down AK074256 SBNO1 A_24_P96961 6,426488 down NM_025106 SPSB1 A_23_P379794 2,189314 down NM_178517 PIGW A_23_P2143 2,6569822 down NM_014752 SPCS2 A_32_P129527 2,056405 down NM_018341 C6orf70 A_23_P210425 2,64471 down NM_181526 MYL9 A_23_P9932 2,433427 up NM_145341 PDCD4 A_23_P85893 2,8213918 up NM_144580 C1orf85 A_23_P132121 3,1560466 down NM_173354 SNF1LK A_23_P388168 2,2454736 down NM_002867 RAB3B A_23_P413576 2,2812605 up NM_003774 GALNT4 A_23_P120345 2,633759 down NM_020651 PELI1 A_24_P183150 2,6177769 up NM_002090 CXCL3 A_32_P78285 2,7450626 down A_32_P78285 A_32_P78285 A_24_P360993 2,1347463 up NM_016511 CLEC1A A_23_P57760 3,7248774 down NM_152282 ACPL2 A_24_P118512 2,2856493 down XR_016757 LOC645207 A_24_P319364 2,8854563 up NM_144503 F11R A_24_P109417 3,3125083 down NM_198545 C1orf187 A_32_P220798 2,6191032 up NM_001773 CD34 A_23_P49459 2,84456 up NM_030941 LOC81691 A_24_P6370 3,7151163 down BC040018 C1orf110 A_23_P69791 2,5615737 up NM_018569 C4orf16 A_23_P374695 2,0104837 up NM_000459 TEK A_23_P37988 2,1964087 down NM_152727 CPNE2 A_24_P192301 4,6593204 up NM_006080 SEMA3A A_24_P940411 2,168471 up AK055190 CXorf36 A_23_P155755 3,701187 up NM_002993 CXCL6 A_24_P297166 2,7729638 down NM_002688 05. SepA_23_P63067 2,2702951 down NM_033657 DAP3 A_23_P141738 2,6524942 down NM_001007559 SS18 A_23_P102000 2,7658746 down NM_001008540 CXCR4

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A_23_P1029 2,243625 down NM_017459 MFAP2 A_23_P29237 2,1126502 up NM_145641 APOL3 A_23_P354864 3,0166483 down NM_173476 CCDC78 A_23_P371966 2,0679681 down AB075826 KIAA1946 A_24_P347447 2,0985894 down NM_014992 DAAM1 A_23_P133263 2,8845963 up NM_002130 HMGCS1 A_23_P408955 2,8124042 up NM_004091 E2F2 A_23_P317591 3,7295218 up NM_006080 SEMA3A A_23_P142533 7,9375796 up NM_000090 COL3A1 A_23_P304511 5,0105767 up NM_032347 ZNF397 A_23_P406508 4,5397487 down NM_005020 PDE1C A_24_P278684 2,92791 down NM_001004285 DFFB A_32_P3783 2,0436368 down THC2655811 THC2655811 A_24_P273972 2,2980943 up NM_000186 CFH A_23_P154037 2,3658412 down NM_001159 AOX1 A_24_P399942 2,0065644 down NM_173694 ATP11C A_23_P4041 3,5727115 up NM_021213 PCTP A_32_P220580 2,3005068 up AK124352 AK124352 A_23_P128246 2,9800282 up NM_007076 HYPE A_23_P349310 2,3124964 down NM_014494 TNRC6A A_24_P363615 2,3949325 down NM_145808 MTPN A_24_P256764 2,9112945 up NM_005964 MYH10 A_32_P106246 2,5299828 up A_32_P106246 A_32_P106246 A_23_P153185 2,0548532 up ENST00000299502 SERPINB2 A_24_P71700 2,324679 down NM_145166 ZBTB47 A_32_P117322 2,0873752 down AV707592 AV707592 A_23_P20502 2,0344129 down NM_130849 SLC39A4 A_24_P14485 2,1892192 down NM_017495 RBM38 A_32_P158181 3,340401 down THC2650074 THC2650074 A_23_P165574 3,223475 up NM_017969 IWS1 A_32_P41744 3,3030565 down THC2728513 THC2728513 A_23_P142974 2,7109485 up NM_001007231 ARHGAP25 A_23_P78037 4,389093 up NM_006273 CCL7 A_23_P215517 2,6862328 up BC009555 KLHL7 A_24_P929003 2,0854266 down S70348 ITGB3 A_32_P235293 2,2566664 up A_32_P235293 A_32_P235293 A_32_P178499 3,294144 up NM_001012984 LOC388284 A_24_P252575 2,008731 up NM_012197 RABGAP1 A_24_P400473 2,0615313 up NM_014655 SLC25A44 A_24_P13475 2,7871833 down ENST00000382108 SPATA13 A_23_P39774 2,4745595 down NM_006857 RY1 A_23_P434040 2,5100536 up BC029609 LOC554206 A_23_P129856 2,5720139 down BY798288 HIC1 A_23_P17870 2,4380746 down NM_012264 C22orf5 A_24_P579356 2,5474775 up NM_001010000 ARHGAP28 A_23_P103256 2,3445795 up NM_021023 CFHR3 A_32_P120791 2,1575294 up BC040303 BC040303 A_24_P795594 2,2602894 down NM_001077691 ALG9 A_23_P23616 3,7118251 down NM_032129 PLEKHN1 A_24_P102283 2,6330552 up AK098835 AK098835 A_23_P4069 2,1636508 down NM_001004313 LOC388335 A_24_P889070 3,125076 down AK023647 AK023647 A_24_P252130 2,2434225 down NM_006238 PPARD A_32_P150152 2,2312264 up THC2618235 THC2618235 A_23_P91727 2,4389668 up NM_012407 PICK1 A_32_P186865 2,0818317 up THC2663329 THC2663329

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A_23_P250462 3,7321334 down NM_001183 ATP6AP1 A_32_P192354 3,0219603 down A_32_P192354 A_32_P192354 A_24_P196851 3,1953943 down NM_006289 TLN1 A_23_P67799 2,951161 up NM_183240 TMEM37 A_32_P73991 2,3656194 up THC2667995 THC2667995 A_23_P374844 2,758994 down NM_015973 GAL A_32_P85360 3,9623613 down THC2770932 THC2770932 A_32_P5040 2,0757215 down NM_203458 NOTCH2NL A_23_P59349 2,0577729 down NM_016217 HECA A_32_P96036 2,025727 down XM_044166 MEX3A A_24_P319088 4,3507986 down NM_005064 CCL23 A_23_P325690 3,2313612 up NM_144698 ANKRD35 A_23_P62967 3,6516583 down NM_018662 DISC1 A_23_P406385 3,378523 down NM_153350 FBXL16 A_24_P130936 2,1555998 down NM_004660 DDX3Y A_24_P115511 3,1246655 down NM_016322 RAB14 A_23_P209167 6,8607073 down NM_005860 FSTL3 A_23_P40847 2,5198908 down NM_004267 CHST2 A_23_P150609 3,2838264 down NM_001007139 IGF2 A_24_P930963 2,1726954 down BC036550 LOC650392 A_23_P148990 2,75811 up NM_031935 HMCN1 A_32_P154872 2,7507024 up THC2675264 THC2675264 A_23_P391506 2,6937232 down NM_016389 IVNS1ABP A_32_P139654 3,008245 down NM_198935 SS18L1 A_23_P215549 2,3229716 down NM_000940 PON3 A_32_P172920 4,3435044 down THC2500237 THC2500237 A_23_P52806 2,2853856 up NM_012104 BACE1 A_23_P159325 3,2560785 down NM_139314 ANGPTL4 A_24_P199251 2,134103 up NM_005447 PAMCI A_23_P213359 2,6533473 down NM_002587 PCDH1 A_24_P266285 2,074357 up NM_152558 IQCE A_32_P166921 2,8451333 down THC2768389 THC2768389 A_32_P140656 2,887268 down ENST00000381298 ENST00000381298A_23_P208422 3,2409594 down NM_003950 F2RL3 A_23_P346086 2,1883743 up NM_001043352 TPM3 A_23_P105747 2,2565634 down NM_018171 APPL2 A_23_P416581 3,0545578 down NM_002073 GNAZ A_23_P67339 2,025022 down NM_020650 RCN3 A_24_P123616 2,92853 down NM_005345 HSPA1A A_23_P149892 2,2280111 down NM_018590 GALNACT-2 A_23_P12363 3,6443617 down NM_005012 ROR1 A_23_P128728 2,2044234 down NM_001172 ARG2 A_23_P79155 2,3796942 down NM_001508 GPR39 A_23_P51339 2,816478 up NM_007034 DNAJB4 A_23_P143673 12,60363 down NM_014310 RASD2 A_23_P163942 2,192719 up NM_003168 SUPT4H1 A_23_P47579 3,1941235 up NM_176822 NLRP14 A_24_P924681 3,7609487 down BQ717518 BQ717518 A_23_P69617 3,8671427 up NM_003728 UNC5C A_24_P97104 3,401842 up NM_001935 DPP4 A_23_P207058 2,038408 down NM_003955 SOCS3 A_24_P54174 3,278639 up NM_001066 TNFRSF1B A_23_P166297 2,6681583 down NM_207630 ABCG1 A_23_P48481 3,156398 up NM_133510 RAD51L1 A_32_P27964 2,0237164 down A_32_P27964 A_32_P27964 A_32_P732971 7,4780693 down AF086511 AF086511

Page 11: Supplemental Figure 1 - Journal of Biological Chemistry€¦ · Supplemental Figure 1. GATA6 is essential for endothelial vessel-like structure formation. Representative images of

A_32_P42780 2,0679462 down A_32_P42780 A_32_P42780 A_23_P37870 2,0711598 up NM_005861 STUB1 A_24_P682285 2,7245414 down NM_005345 HSPA1A A_24_P355816 2,1737533 down NM_018370 DRAM A_24_P254285 2,0894713 up NM_052865 C20orf72 A_23_P339773 5,2706614 up NM_182752 FAM79A A_24_P372901 2,1791449 up NM_000431 MVK A_32_P84333 2,2999682 up THC2582300 THC2582300 A_23_P68155 5,5024657 up NM_022168 IFIH1 A_23_P19134 3,9306026 down NM_032119 GPR98 A_23_P377806 2,2034044 down NM_014494 TNRC6A A_32_P207420 3,9389434 down THC2612025 THC2612025 A_24_P339429 2,3693755 down NM_021012 KCNJ12 A_23_P79360 2,470086 up NM_052946 NOSTRIN A_23_P122068 2,5181239 down NM_181435 C1QTNF3 A_32_P82580 6,2420564 up A_32_P82580 A_32_P82580 A_32_P110872 2,4942496 down BC001077 RP11-151A6.2 A_32_P94444 2,0072129 down NM_002770 PRSS2 A_24_P385280 2,080944 down NM_000696 ALDH9A1 A_32_P16339 2,1557329 up NM_173545 C2orf13 A_23_P211247 2,159941 up NM_206962 PRMT2 A_24_P945181 2,038961 down NM_013286 RBM15B A_24_P303193 3,6279366 up BG036557 BG036557 A_24_P20607 2,553109 down NM_005409 CXCL11 A_23_P322756 2,8556337 up ENST00000373644 CXXC6 A_23_P253783 3,2874494 down AK027396 MFSD2 A_23_P56069 3,733466 down NM_015578 LSM14A A_24_P55250 2,0589955 down NM_016063 HDDC2 A_23_P201551 2,7309594 down NM_006113 VAV3 A_23_P204269 2,3012054 down NM_006313 USP15 A_23_P428260 3,3871396 up NM_152999 STEAP2 A_23_P160567 4,93688 up NM_032257 ZMYND12 A_24_P273799 2,0628414 up ENST00000301042 ZNF641 A_24_P77008 4,0702596 down NM_000963 PTGS2 A_23_P171107 2,3625658 up NM_033031 CCNB3 A_32_P66306 11,357914 up BC039664 LOC400604 A_32_P183983 3,8808625 up BC037838 BC037838 A_23_P157465 2,1406043 down NM_005671 UBXD6 A_23_P88303 2,3799665 up NM_021979 HSPA2 A_23_P35871 2,093721 up NM_024680 E2F8 A_24_P68311 6,0273542 up NM_015180 SYNE2 A_23_P216200 2,2981308 up NM_018361 AGPAT5 A_23_P74290 2,0115075 down NM_052942 GBP5 A_32_P232214 9,941031 down XM_371250 LOC388630 A_24_P260101 2,2539232 up NM_007289 MME A_32_P146635 5,248275 up AK091132 AK091132 A_23_P257307 13,977777 up NM_000354 SERPINA7 A_23_P200928 2,083712 down NM_002508 NID1 A_23_P161218 4,8156204 up NM_014391 ANKRD1 A_24_P659113 2,5068915 up NM_152523 CCNYL1 A_24_P460763 2,15236 up AK022443 AK022443 A_23_P204654 3,5878952 down NM_000899 KITLG A_23_P115444 2,9201624 up NM_005092 TNFSF18 A_24_P48403 3,0337121 down NM_005433 YES1 A_23_P211252 2,9329407 up NM_001001438 LSS A_24_P346431 3,5486634 down NM_022748 TNS3

Page 12: Supplemental Figure 1 - Journal of Biological Chemistry€¦ · Supplemental Figure 1. GATA6 is essential for endothelial vessel-like structure formation. Representative images of

A_23_P118392 14,0050125 down NM_016084 RASD1 A_23_P390116 2,903542 down NM_153023 SPATA13 A_23_P106682 2,5390744 down NM_001424 EMP2 A_24_P535256 2,820347 down AK001903 AK001903 A_23_P436266 2,5879183 down AF062385 AF062385 A_23_P52531 2,3159432 down NM_152644 FAM24B A_24_P190168 2,1156409 up NM_014573 TMEM97 A_32_P108738 2,0670025 down AK023472 AK023472 A_32_P183047 2,4093328 up THC2669961 THC2669961 A_24_P382533 5,666034 down NM_005386 NNAT A_24_P602168 2,2278488 up THC2645797 THC2645797 A_24_P348806 2,4880066 down NM_175058 PLEKHA7 A_24_P371670 4,3283815 up NM_006805 HNRPA0 A_24_P123052 2,3563225 down NM_002886 RAP2B A_24_P298894 2,1062171 down XR_018724 LOC399956 A_32_P98739 5,4677954 up NM_001080444 LOC150084 A_23_P205910 2,3059907 down NM_004727 SLC24A1 A_23_P256391 2,4456184 down NM_002078 GOLGA4 A_23_P142380 2,1139982 down NM_005858 AKAP8 A_23_P134744 2,4240878 down NM_024787 RNF122 A_32_P148118 2,2927241 down ENST00000331696 ENST00000331696A_24_P411899 2,1868536 down NM_183419 RNF19 A_24_P244699 3,3583746 down NM_018283 NUDT15 A_24_P116700 2,228712 down NM_001004313 LOC388335 A_23_P103951 2,3431447 down A_23_P103951 A_23_P103951 A_23_P67169 17,725643 down NM_000641 IL11 A_32_P201773 2,5651813 up NM_015365 AMMECR1 A_32_P212343 2,4309313 down AK057710 AK057710 A_23_P73096 2,074896 up AW993939 AW993939 A_24_P28165 2,0382187 up NM_015071 ARHGAP26 A_23_P3963 2,110246 down NM_014603 CDR2L A_32_P192594 2,3813717 up BC014066 BC014066 A_24_P96403 2,070966 down NM_001001890 RUNX1 A_23_P310274 2,3385475 down NM_002770 PRSS2 A_23_P89708 3,0985172 up NM_018129 PNPO A_24_P626951 2,4646344 down ENST00000390253 ENST00000390253A_24_P404245 2,2870593 up NM_002861 PCYT2 A_23_P56328 5,6796494 down NM_031310 PLVAP A_24_P294199 2,409441 up NM_006226 PLCL1 A_23_P39074 2,0861447 down NM_006270 RRAS A_24_P120934 2,0068746 down NM_006705 GADD45G A_23_P17430 2,4487956 down NM_017495 RBM38 A_32_P171530 4,7745986 up BC038371 BC038371 A_23_P165722 2,1051257 down NM_004846 EIF4E2 A_23_P27048 2,263573 up NM_152464 C17orf32 A_24_P797455 2,0696337 down AK056910 AK056910 A_24_P170025 2,1845217 down A_24_P170025 A_24_P170025 A_23_P85952 5,1924443 up NM_024901 DENND2D A_32_P10311 3,0666027 down AF305816 AF305816 A_23_P397899 3,0398905 up NM_021218 C9orf80 A_23_P46964 2,5788956 up NM_017902 HIF1AN A_32_P66364 2,3263745 up NM_001080545 PPP1R1C A_23_P67529 2,992377 down NM_002250 KCNN4 A_24_P410610 3,9146118 up BC108742 DPYD A_23_P28485 2,5164883 up NM_012198 GCA A_32_P178537 2,1277828 down AI910722 AI910722

Page 13: Supplemental Figure 1 - Journal of Biological Chemistry€¦ · Supplemental Figure 1. GATA6 is essential for endothelial vessel-like structure formation. Representative images of

A_23_P256561 2,36492 up NM_006068 TLR6 A_23_P217528 2,4515636 up NM_007250 KLF8 A_32_P204691 2,3788497 up BC038747 BC038747 A_32_P146394 2,1396356 down AI537201 AI537201 A_32_P21255 2,2067022 up NM_013309 SLC30A4 A_23_P53663 2,031502 down NM_002583 PAWR A_23_P25503 2,433953 down NM_014923 FNDC3A A_32_P82462 2,8979588 down BC021861 LOC554202 A_23_P9166 3,0049422 down NM_006289 TLN1 A_23_P17814 3,8494227 up NM_015715 PLA2G3 A_23_P200792 2,0080032 down NM_024408 NOTCH2 A_32_P147063 2,4310198 down AL355688 AL355688 A_32_P127368 2,0079293 down THC2689802 THC2689802 A_32_P20679 2,0271556 up AV661884 AV661884 A_23_P106405 3,2227654 down NM_002487 NDN A_23_P70670 2,4887023 up NM_004233 CD83 A_32_P167212 5,8550973 down A_32_P167212 A_32_P167212 A_24_P393958 2,6498172 up NM_007034 DNAJB4 A_23_P22224 2,1330185 down NM_004095 EIF4EBP1 A_32_P62026 2,9364069 up THC2733296 THC2733296 A_24_P200420 2,1136878 up NM_014331 SLC7A11 A_24_P234838 2,1080394 down NM_032420 PCDH1 A_24_P914466 3,9859655 up THC2736967 THC2736967 A_23_P45871 5,8768196 up NM_006820 IFI44L A_24_P162211 3,1337106 up NM_001001438 LSS A_24_P300379 3,0910864 down NM_153370 PI16 A_24_P173754 2,2241712 down NM_030806 C1orf21 A_24_P112395 2,6489666 up NM_022129 PBLD A_24_P788227 12,942948 up BC041856 DUXAP10 A_23_P34478 4,625593 up NM_017655 GIPC2 A_23_P385105 3,1450067 up NM_032726 PLCD4 A_24_P925124 3,055353 up THC2515402 THC2515402 A_24_P458168 3,0397716 down A_24_P458168 A_24_P458168 A_24_P699737 2,1179597 down AK022339 AK022339 A_23_P75299 2,0375175 down NM_022126 LHPP A_24_P944714 11,395152 down ENST00000381655 ENST00000381655A_24_P398064 2,1552744 up ENST00000378078 KIAA0258 A_24_P50543 3,0226536 up BC031266 TRIM69 A_24_P202840 2,5271404 down AK095499 SIRPB2 A_32_P3127 2,0129504 down AF038199 AF038199 A_32_P758423 2,6173885 down AL833908 FLJ40176 A_24_P54847 2,3894942 up CR603201 CR603201 A_23_P169479 3,4608417 up ENST00000341700 GNA14 A_23_P127957 2,2591348 down NM_182904 P4HA3 A_23_P411922 2,56216 up NM_012272 PRPF40B A_23_P4662 2,6806 up NM_005178 BCL3 A_32_P32061 2,9120104 down NM_013310 C2orf27 A_23_P116902 5,299849 up NM_021071 ART4 A_23_P336198 3,7016246 down NM_138426 GLCCI1 A_24_P110799 2,458836 up NM_002340 LSS A_23_P144916 2,9537988 down NM_005110 GFPT2 A_23_P124733 2,108658 up NM_015697 COQ2 A_24_P934755 2,0276213 down ENST00000373575 ENST00000373575A_23_P135257 2,3389788 down NM_002771 PRSS3 A_23_P302060 2,5876386 down NM_176891 IFNE1 A_23_P105592 2,0959663 up BC016140 MVK

Page 14: Supplemental Figure 1 - Journal of Biological Chemistry€¦ · Supplemental Figure 1. GATA6 is essential for endothelial vessel-like structure formation. Representative images of

A_23_P32233 2,5144973 down NM_004235 KLF4 A_24_P166144 2,00839 up NM_018227 UBE1L2 A_23_P159907 2,215646 up NM_030801 MAGED4 A_24_P195400 2,0440829 up XR_019065 LOC391247 A_24_P892402 5,732879 down AK057652 AK057652 A_24_P256219 8,028948 down AF055376 MAF A_32_P90468 2,1496494 up A_32_P90468 A_32_P90468 A_24_P116017 3,0370686 down NM_002813 PSMD9 A_23_P357724 5,107474 down NM_002246 KCNK3 A_24_P320727 2,4952548 up NM_152748 KIAA1324L A_23_P84860 2,1035573 up NM_007177 FAM107A A_23_P70318 2,1745849 up NM_014936 ENPP4 A_23_P144096 4,620144 down NM_145071 CISH A_24_P73577 2,4869878 up NM_170697 ALDH1A2 A_23_P328237 2,7195427 up NM_194285 SPTY2D1 A_23_P391906 2,2089899 down BC044246 KIAA1913 A_24_P199929 2,127354 up NM_016516 VPS54 A_32_P147324 2,0133648 down BC038355 BC038355 A_23_P160968 3,8322353 down NM_018891 LAMC2 A_32_P62342 2,068671 up BC039145 GLT8D3 A_23_P56559 2,169827 up NM_005771 DHRS9 A_23_P401774 3,11717 up NM_018712 ELMOD1 A_23_P31765 2,85401 down NM_006823 PKIA A_32_P103945 2,4210916 up NM_212543 B4GALT4 A_24_P29876 2,7693498 up NM_018361 AGPAT5 A_24_P66969 9,467335 up NM_001013698 LOC440087 A_23_P213385 2,2451093 down NM_006317 BASP1 A_24_P207727 2,3351798 down NM_001003891 PCQAP A_32_P136967 3,2296495 up ENST00000328046 KLHL15 A_23_P166797 4,4510617 up NM_022147 RTP4 A_23_P341860 3,0439007 up BC073815 BC073815 A_23_P143016 2,996035 down NM_006673 ARID5A A_23_P333705 2,0602386 up NM_002498 NEK3 A_32_P10133 3,2717597 down AK022045 AK022045 A_23_P82929 2,6399376 down NM_002514 NOV A_23_P8820 9,119442 up NM_001442 FABP4 A_24_P933565 2,1502516 up NM_024989 PGAP1 A_24_P222184 2,0805058 down AK091439 TMEM48 A_24_P338788 2,2252522 up NM_145203 CSNK1A1L A_23_P374339 6,132029 up NM_152794 HIF3A A_23_P338479 2,078892 down NM_014143 CD274 A_23_P161297 2,2075818 up NM_018245 OGDHL A_24_P74753 3,7052972 down NM_001183 ATP6AP1 A_24_P943709 3,8154297 up AW444553 AW444553 A_23_P6909 8,791442 up NM_178445 CCRL1 A_23_P108331 2,4423492 down NM_003021 SGTA A_23_P394986 3,9053192 down NM_153836 CREG2 A_23_P84576 3,257143 up NM_053034 ANTXR1 A_24_P156490 2,2062895 down NM_002247 KCNMA1 A_23_P203023 2,4794416 down NM_002906 RDX A_24_P133905 4,296356 down NM_005064 CCL23 A_23_P43557 2,1394556 up NM_024820 DENND1A A_32_P93517 2,6796424 up THC2725553 THC2725553 A_32_P167631 2,0770273 up THC2616783 THC2616783 A_24_P634845 2,4267364 down THC2748223 THC2748223 A_23_P126613 2,123889 up NM_080429 AQP10

Page 15: Supplemental Figure 1 - Journal of Biological Chemistry€¦ · Supplemental Figure 1. GATA6 is essential for endothelial vessel-like structure formation. Representative images of

A_23_P303423 2,1800368 up ENST00000264313 ENST00000264313A_32_P162716 2,093909 down CB529149 CB529149 A_23_P207507 6,248824 up NM_003786 ABCC3 A_24_P932887 3,6868727 down AK097227 SPOCD1 A_24_P350576 2,7412837 up AB011123 TNIK A_23_P398172 3,5533264 down NM_020819 FAM135A A_23_P203957 3,666297 up NM_175861 TMTC1 A_32_P460399 2,4922469 up AL365520 AL365520 A_32_P183442 2,1188269 down BF217859 BF217859 A_23_P127033 3,9132042 up NM_024693 ECHDC3 A_23_P100868 2,004936 down NM_001033580 MYOHD1 A_24_P60887 4,43311 up NM_001146 ANGPT1 A_24_P383277 2,087474 up NM_030650 KIAA1715 A_23_P104705 2,941846 up NM_001532 SLC29A2 A_24_P322741 2,7088594 down NM_000628 IL10RB A_23_P18818 2,4440043 up NM_015455 CNOT6 A_24_P54390 2,5923986 down NM_170672 RASGRP3 A_24_P382026 2,5820906 up NM_020679 MIF4GD A_23_P407614 2,3627942 down NM_152901 PYDC1 A_24_P288848 2,5067446 up AK094877 CXorf36 A_23_P22027 2,0567014 up NM_198336 INSIG1 A_23_P64898 3,9105253 up NM_005810 KLRG1 A_23_P360754 2,134065 down NM_005099 ADAMTS4 A_23_P36018 2,4364703 up NM_014312 VSIG2 A_24_P245589 4,571072 down NM_031310 PLVAP A_23_P135273 3,7480435 down NM_001005336 DNM1 A_23_P95930 3,0989678 down NM_003483 HMGA2 A_24_P787947 2,2678444 down NM_001005404 YPEL2 A_23_P18649 2,2199843 up AK026709 FAT4 A_23_P431939 2,6042385 up NM_001531 MR1 A_23_P30495 2,0796645 up NM_000859 HMGCR A_24_P315256 2,9350567 down A_24_P315256 A_24_P315256 A_24_P680606 3,158682 down BC006530 LOC554175 A_23_P146576 2,040719 down NM_021996 GBGT1 A_24_P270496 4,5744576 up NM_006491 NOVA1 A_32_P39440 2,8222866 down BC030813 BC030813 A_23_P500353 5,1140313 down NM_021614 KCNN2 A_23_P103405 2,380262 up AK023086 AK023086 A_23_P76992 2,591131 down NM_002632 PGF A_23_P91512 8,921049 down NM_144492 CLDN14 A_23_P337270 3,41412 down NM_001031741 NEK10 A_32_P71675 2,4955344 down ENST00000378266 LOC388588 A_23_P380754 2,255729 down NM_002769 PRSS1 A_24_P308051 4,3971815 down NM_001371 DNAH8 A_23_P111766 2,2821987 down A_23_P111766 A_23_P111766 A_23_P17103 3,4948363 down NM_025244 TSGA10 A_23_P130359 4,431625 up NM_030672 ARHGAP28 A_23_P10374 2,4090536 down NM_014925 R3HDM2 A_23_P357284 2,6296186 down NM_005282 GPR4 A_23_P394605 2,4714503 down NM_021982 SEC24A A_32_P197561 3,5754108 down AK123757 AK123757 A_23_P126899 2,5229926 up NM_003846 PEX11B A_23_P346969 2,3079662 up NM_006219 PIK3CB A_23_P401606 7,499913 down NM_005711 EDIL3 A_23_P208310 2,3600178 down NM_012099 CD3EAP A_23_P158885 2,0990236 down AK096342 ZNF93

Page 16: Supplemental Figure 1 - Journal of Biological Chemistry€¦ · Supplemental Figure 1. GATA6 is essential for endothelial vessel-like structure formation. Representative images of

A_32_P54553 2,0544164 up ENST00000292729 USP41 A_23_P83857 2,4185236 up NM_000240 MAOA A_24_P655849 2,2271228 up BM802662 BM802662 A_24_P539275 2,6793265 up A_24_P539275 A_24_P539275 A_24_P938293 2,184511 down NM_005524 HES1 A_23_P33768 2,3346288 down NM_004799 ZFYVE9 A_32_P103508 2,3954482 down AK096022 LOC286025 A_24_P252996 6,56093 down NM_000804 FOLR3 A_32_P190613 2,7709062 down THC2710559 THC2710559 A_23_P148249 2,3102658 down NM_024817 THSD4 A_24_P530690 2,0218253 up THC2756047 THC2756047 A_23_P17998 2,217474 down NM_005524 HES1 A_24_P23400 2,3476517 down NM_005629 SLC6A8 A_32_P53183 2,4758732 up AF165514 HSD17B7P2 A_23_P16953 21,209743 up NM_000867 HTR2B A_23_P80832 2,064837 down NM_080652 TMEM41A A_24_P191750 2,1918876 up NM_153365 TAPT1 A_23_P502470 2,7617588 down NM_002184 IL6ST A_23_P432385 2,6215804 up NM_018267 H2AFJ A_23_P127426 3,1033845 up NM_003273 TM7SF2 A_23_P156327 2,6986637 down NM_000358 TGFBI A_23_P166109 3,7907221 up NM_198391 FLRT3 A_24_P364066 6,54156 down BC030112 BC030112 A_23_P324327 4,5895634 down NM_016235 GPRC5B A_24_P349590 2,056208 up A_24_P349590 A_24_P349590 A_24_P501544 2,2892356 down NM_001005404 YPEL2 A_24_P930391 2,1713073 up AK022351 AK022351 A_23_P422933 3,156145 up NM_020809 ARHGAP20 A_32_P80610 3,0291953 down AK124080 AK124080 A_24_P551028 3,395809 down NM_001001664 LOC339745 A_32_P17525 2,839532 down THC2664860 THC2664860 A_32_P139708 3,0072722 up THC2664742 THC2664742 A_24_P313186 2,100606 down NM_006888 CALM1 A_23_P139669 2,0363014 up NM_006931 SLC2A3 A_24_P916845 2,039928 down THC2514800 THC2514800 A_24_P646185 2,1727448 down NM_001048249 DKFZP686E2158 A_24_P79631 2,235074 down ENST00000373210 EIF2C4 A_23_P133902 2,4586565 up NM_014068 PSORS1C1 A_23_P87150 2,359014 down NM_004811 LPXN A_24_P926580 2,3011456 up AK001808 AK001808 A_32_P159651 2,2332096 up NM_003884 PCAF A_23_P73023 2,5171163 up NM_015173 TBC1D1 A_24_P16730 2,183827 up NM_030650 KIAA1715 A_23_P336796 2,2374334 up AL832209 GLT8D3 A_32_P208403 2,4858599 down NM_053064 GNG2 A_23_P8812 2,9716127 up W60781 W60781 A_23_P147098 2,3597221 down NM_145808 MTPN A_23_P416608 3,6157544 down NM_013995 LAMP2 A_24_P215882 2,772459 down NM_001176 ARHGDIG A_23_P257993 2,9770265 up NM_004944 DNASE1L3 A_32_P226186 2,5140915 down THC2623121 THC2623121 A_32_P221641 2,024782 up A_32_P221641 A_32_P221641 A_23_P99163 2,1995473 down NM_018370 DRAM A_23_P94095 3,430506 down NM_198401 ANKRD46 A_23_P307544 2,1929858 down NM_025179 PLXNA2 A_24_P186936 2,6646335 down NM_000501 ELN

Page 17: Supplemental Figure 1 - Journal of Biological Chemistry€¦ · Supplemental Figure 1. GATA6 is essential for endothelial vessel-like structure formation. Representative images of

A_23_P131463 2,0437794 down NM_016552 ANKMY1 A_24_P145134 2,6045508 up BC010943 OSMR A_23_P310921 2,4952087 up NM_002589 PCDH7 A_24_P305623 2,2678654 down NM_006134 TMEM50B A_32_P88605 2,1942337 down A_32_P88605 A_32_P88605 A_23_P83098 2,720984 up NM_000689 ALDH1A1 A_32_P112263 7,107952 down A_32_P112263 A_32_P112263 A_24_P148762 2,538011 up NM_002182 IL1RAP A_32_P74409 2,0649035 down ENST00000339446 LOC387763 A_32_P29118 2,7267535 up NM_152754 SEMA3D A_32_P85344 2,1957512 down THC2769342 THC2769342 A_32_P24295 2,4965034 down A_32_P24295 A_32_P24295 A_32_P226205 2,372795 up AB051549 ZFHX2 A_23_P113212 3,196376 up NM_018004 TMEM45A A_23_P384965 5,0610385 up THC2616697 THC2616697 A_23_P59022 2,1691797 up NM_033502 TRERF1 A_23_P64611 2,7469823 down NM_176798 P2RY6 A_24_P396231 2,4003346 down BC040653 BC040653 A_23_P381577 2,0226548 up NM_145011 ZNF25 A_32_P76602 2,2330124 up THC2651036 THC2651036 A_23_P210849 2,2024257 down NM_002862 PYGB A_23_P19650 2,2169318 down NM_003381 VIP A_24_P167012 3,611247 down NM_005118 TNFSF15 A_23_P142765 3,0190766 down NM_002236 KCNF1 A_23_P101742 2,5460334 up NM_172251 MRPL54 A_24_P289208 2,7160704 down NM_003226 TFF3 A_23_P170378 2,5870106 down AY008410 PMCHL1 A_32_P25737 3,692385 up CR936642 CHIC1 A_32_P144852 2,0505965 up CR622110 CR622110 A_32_P37971 3,4136257 down BI256572 BI256572 A_23_P213638 3,025437 down NM_024594 PANK3 A_23_P118615 3,046164 up NM_007168 ABCA8 A_24_P409309 2,7776039 up AF217970 AF217970 A_24_P348006 16,112026 down NM_016084 RASD1 A_23_P134058 2,159364 up NM_033069 C6orf114 A_23_P16469 2,2320843 down NM_001005377 PLAUR A_24_P79955 2,5738251 up NM_005105 RBM8A A_23_P101434 2,2774658 down NM_033297 NLRP12 A_24_P343255 2,5251598 up NM_057161 KLHDC3 A_23_P92672 3,516745 up NM_002538 OCLN A_24_P46659 3,2827172 down ENST00000316149 C6orf66 A_23_P383835 2,3829615 up NM_005891 ACAT2 A_23_P31399 2,3049254 up NM_000305 PON2 A_23_P154962 2,975762 down BC035246 KIAA1666 A_23_P343104 4,560643 down AK055463 FLJ30901 A_23_P65230 2,126079 down NM_032813 TMTC4 A_24_P343929 7,145502 up NM_016817 OAS2 A_24_P364381 2,2228432 up NM_052845 MMAB A_23_P70843 2,6113842 down NM_199186 BPGM A_32_P209163 2,609875 up A_32_P209163 A_32_P209163 A_23_P53162 2,281265 up NM_003156 STIM1 A_24_P10233 3,825277 down NM_014326 DAPK2 A_23_P213350 2,5960488 down A_23_P213350 A_23_P213350 A_23_P201287 3,8134027 up NM_015074 KIF1B A_32_P45168 2,5386002 down NR_002211 MEIS3P1 A_32_P104417 9,148146 down BX114143 BX114143

Page 18: Supplemental Figure 1 - Journal of Biological Chemistry€¦ · Supplemental Figure 1. GATA6 is essential for endothelial vessel-like structure formation. Representative images of

A_23_P257003 2,7257204 down NM_006200 PCSK5 A_23_P75786 4,754054 up NM_016582 SLC15A3 A_23_P138495 2,2010098 down NM_006504 PTPRE A_23_P314250 2,8764372 up NM_033387 FAM78A A_23_P110403 2,5730655 up NM_014476 PDLIM3 A_24_P257416 2,7658691 up NM_002089 CXCL2 A_24_P261567 2,8213289 up NM_030792 GDPD5 A_23_P217797 2,4980423 down NM_004660 DDX3Y A_32_P137604 3,802213 up BC018597 BC018597 A_23_P40611 2,1907768 up NM_000355 TCN2 A_23_P369899 6,396049 down NM_015444 TMEM158 A_23_P27306 3,1068718 up NM_130386 COLEC12 A_24_P37903 2,80685 down THC2603732 THC2603732 A_23_P38346 2,7217252 up NM_024119 LGP2 A_23_P31046 2,141198 down NM_025107 MYCT1 A_23_P165582 2,652997 up NM_006226 PLCL1 A_23_P7752 3,4340024 up NM_020796 SEMA6A A_23_P118406 2,1455293 down NM_001033046 C17orf62 A_23_P36531 7,3238473 up NM_004616 TSPAN8 A_23_P253921 2,7128909 down NM_018651 ZNF167 A_23_P128230 2,4413579 down NM_002135 NR4A1 A_23_P51646 2,1171203 down NM_004073 PLK3 A_23_P19517 2,2308857 down NM_002224 ITPR3 A_23_P103496 9,287682 up NM_052941 GBP4 A_24_P364072 6,5434427 down THC2574620 THC2574620 A_24_P55465 2,4652028 down NM_145808 MTPN A_24_P48856 2,5553787 down NM_000071 CBS A_23_P11362 2,7574298 up NM_014735 PHF16 A_23_P309515 2,8409443 up NM_152387 KCTD18 A_23_P393099 2,9537802 down NM_003226 TFF3 A_32_P1360 2,3578782 down THC2670603 THC2670603 A_24_P373844 2,5570211 down THC2582042 THC2582042 A_23_P3014 2,7894113 up NM_005615 RNASE6 A_23_P405129 2,2998679 down NM_000428 LTBP2 A_23_P26629 2,7460673 down NM_013258 PYCARD A_23_P149992 2,269269 up NM_020992 PDLIM1 A_24_P416997 2,5891898 up NM_145641 APOL3 A_23_P7144 2,6885767 up NM_001511 CXCL1 A_23_P123060 3,9997818 down NM_002214 ITGB8 A_23_P359647 2,4700596 up NM_138714 NFAT5 A_24_P128524 2,1236963 down NM_012405 ICMT A_24_P137713 2,4145753 up NM_030899 ZNF323 A_23_P213141 2,5264056 down NM_015271 TRIM2 A_23_P113245 2,0320594 down D14041 RBPJ A_23_P103011 2,2566607 down NM_004914 RAB36 A_23_P91346 2,36589 down BC008667 BC008667 A_24_P262321 2,0063107 up NM_173622 CDRT4 A_23_P137634 2,464337 up NM_002763 PROX1 A_32_P114284 4,6917973 up NM_001079526 IKZF2 A_32_P225328 3,3136709 down A_32_P225328 A_32_P225328 A_32_P183218 2,1375942 up ENST00000375256 ZNF367 A_23_P302568 4,672112 up NM_003459 SLC30A3 A_24_P396980 2,185509 up NM_053024 PFN2 A_23_P36700 2,2669356 up NM_018009 TAPBPL A_24_P645765 2,7955709 down NM_020782 KLHDC5 A_23_P101871 2,7743437 down NM_024907 FBXO17

Page 19: Supplemental Figure 1 - Journal of Biological Chemistry€¦ · Supplemental Figure 1. GATA6 is essential for endothelial vessel-like structure formation. Representative images of

A_23_P115478 13,64964 down NM_013358 PADI1 A_23_P201279 2,2049248 up NM_006048 UBE4B A_23_P374389 2,0666502 down NM_138499 PWWP2 A_23_P30995 2,0251446 down NM_016230 CYB5R4 A_23_P98350 3,3276336 up NM_001165 BIRC3 A_23_P321223 2,7790058 down NM_002674 PMCH A_23_P166306 2,5616534 down NM_000071 CBS A_24_P188377 2,4279022 down NM_000574 CD55 A_23_P38505 4,676188 up NM_022059 CXCL16 A_23_P83159 2,0371728 down NM_018847 KLHL9 A_24_P15621 2,8331118 down NR_003083 SLC6A10P A_23_P26878 3,0013008 up NM_030808 NDEL1 A_23_P29784 2,1450415 up AL096748 ARMC8 A_32_P599 5,958772 up A_32_P599 A_32_P599 A_32_P49854 2,13288 up THC2697511 THC2697511 A_32_P59302 3,3680818 down ENST00000372583 HIVEP3 A_23_P61967 2,96892 up NM_014469 HNRNPG-T A_23_P32175 2,3319228 down NM_014368 LHX6 A_23_P74229 2,7881591 up NM_032017 STK40 A_23_P381945 2,055214 down NM_005556 KRT7 A_24_P481997 3,6519272 up THC2698892 THC2698892 A_32_P170664 5,4291983 up AK024898 AK024898 A_24_P703674 3,3064456 up AK023907 AK023907 A_23_P392126 2,1414478 up NM_001076680 LOC201229 A_23_P409966 2,2544131 up NM_025252 RAPH1 A_24_P942786 2,1335444 down AK024870 AK024870 A_24_P451992 2,3015757 up XR_018393 LOC342705 A_32_P184448 5,4021873 up AK129955 C18orf34 A_32_P175979 2,7442534 up BG686022 BG686022 A_23_P64792 2,6408029 up NM_014505 KCNMB4 A_23_P422911 3,899349 down NM_153456 HS6ST3 A_23_P155185 2,020154 down ENST00000256031 ATP13A3 A_24_P343621 3,462794 up NM_024693 ECHDC3 A_23_P17287 2,3316453 down NM_001039613 IAH1 A_23_P127565 2,4522283 down NM_178834 LAYN A_23_P62932 3,491097 down NM_001677 ATP1B1 A_32_P187143 3,808199 down A_32_P187143 A_32_P187143 A_23_P69179 2,8911986 down NM_018192 LEPREL1 A_23_P137697 13,838851 up NM_003005 SELP A_23_P381746 6,1972146 down AB051500 ASXL3 A_32_P23872 5,15505 down A_32_P23872 A_32_P23872 A_32_P117453 2,027054 down BC044628 BC044628 A_32_P37360 2,7404969 up NM_145315 LACE1 A_23_P200096 4,454818 down NM_025106 SPSB1 A_32_P142440 6,156523 up NM_174936 PCSK9 A_23_P64828 2,1438832 up NM_002534 OAS1 A_23_P254888 2,304265 down NM_003461 ZYX A_23_P134835 2,4547768 down NM_018371 ChGn A_24_P394246 2,0157914 down NM_016479 SCOTIN A_32_P88262 4,05687 up AK094547 FLJ37228 A_24_P850336 2,300124 up A_24_P850336 A_24_P850336 A_23_P77493 2,7235007 down NM_006086 TUBB3 A_23_P82324 2,5130322 down NM_032415 CARD11 A_23_P74928 4,1742887 up NM_001531 MR1 A_23_P87401 2,5439718 up NM_030792 GDPD5 A_24_P166807 5,146423 up NM_005079 TPD52

Page 20: Supplemental Figure 1 - Journal of Biological Chemistry€¦ · Supplemental Figure 1. GATA6 is essential for endothelial vessel-like structure formation. Representative images of

A_23_P331670 2,6852376 down NM_002862 PYGB A_23_P215642 2,284122 down NM_022748 TNS3 A_32_P195793 4,1165037 up THC2559650 THC2559650 A_23_P94636 2,13581 down NM_018835 RC3H2 A_23_P153855 2,5093577 down ENST00000355095 ENST00000355095A_24_P148261 9,917359 down ENST00000366930 TGFB2 A_23_P66241 2,1919322 down NM_176870 MT1M A_23_P350551 2,1097195 down NM_138425 C12orf57 A_32_P17984 2,3980057 up THC2709254 THC2709254 A_23_P99515 6,7243104 down NM_032849 C13orf33 A_24_P362931 3,1164272 down NM_003615 SLC4A7 A_23_P337729 2,1549947 up NM_024789 TMEM180 A_23_P66137 2,0655506 down NM_014587 SOX8 A_24_P226970 10,58191 down NM_014951 ZNF365 A_24_P229536 2,427107 up NM_001005733 C21orf34 A_24_P252497 2,0323603 down NM_025195 TRIB1 A_24_P53215 2,503992 up NM_199242 UNC13D A_23_P213562 4,0318575 down NM_001992 F2R A_23_P99653 2,7480557 down ENST00000390439 ENST00000390439A_24_P532232 2,6470103 down NM_182898 CREB5 A_23_P65996 2,7719128 up NM_015247 CYLD A_24_P860797 2,132962 up ENST00000244221 PAIP2B A_24_P42564 4,5905814 up BC027947 HS1BP3 A_24_P183128 2,1065156 up NM_016619 PLAC8 A_23_P412562 2,260461 up NM_174896 C1orf162 A_24_P101128 2,27817 up NM_005509 DMXL1 A_23_P101193 3,7800374 down NM_001080467 MYO5B A_23_P158096 2,54488 down AK021957 COL27A1 A_23_P213551 2,2149205 up NM_001892 CSNK1A1 A_24_P332314 3,396763 up NM_198947 FAM111B A_24_P381945 2,591983 down NM_002134 HMOX2 A_23_P127186 2,2840354 down NM_206862 TACC2 A_24_P601695 2,0330215 up AK026194 AK026194 A_24_P362916 2,6747181 up NM_015141 GPD1L A_23_P103070 4,142324 down NM_003405 YWHAH A_23_P66038 2,6282628 down NM_013304 ZDHHC1 A_23_P87049 2,5234103 up NM_003105 SORL1 A_24_P282578 2,6772566 up NM_003145 SSR2 A_23_P86610 7,42884 down NM_014951 ZNF365 A_32_P104000 2,5057228 up NM_173475 DCUN1D3 A_24_P357847 2,4550304 down BC030813 BC030813 A_23_P19226 2,1995435 down NM_013352 DSE A_23_P125278 2,334324 down NM_005409 CXCL11 A_32_P196520 2,3124464 up AK023159 AK023159 A_23_P17345 2,6715093 up NM_005461 MAFB A_23_P111311 4,8288984 down NM_144497 AKAP12 A_23_P436369 2,0008554 up NM_015687 FILIP1 A_24_P227121 2,116041 down THC2685096 THC2685096 A_23_P361584 2,3213897 down NM_152680 TMEM154 A_23_P431388 3,5211012 down NM_144569 SPOCD1 A_32_P220762 2,1264408 up AK123248 AK123248 A_23_P58396 2,8554463 down NM_016205 PDGFC A_23_P23171 3,211585 down NM_017629 EIF2C4 A_23_P116942 5,2565203 up NM_002286 LAG3 A_23_P145889 2,012196 down NM_012395 PFTK1 A_24_P231104 2,3370836 up NM_001003679 LEPR

Page 21: Supplemental Figure 1 - Journal of Biological Chemistry€¦ · Supplemental Figure 1. GATA6 is essential for endothelial vessel-like structure formation. Representative images of

A_23_P18372 2,6937144 down NM_032047 B3GNT5 A_23_P316601 4,93872 down NM_006912 RIT1 A_23_P214897 4,4234986 down NM_144497 AKAP12 A_32_P224327 2,3316617 down AK056401 LOC730091 A_32_P926336 4,325893 down NM_001014373 C19orf31 A_23_P215897 2,0440652 down NM_183419 RNF19 A_24_P721828 2,0043523 up AK022015 AK022015 A_23_P257296 2,997088 down NM_003226 TFF3 A_23_P252449 5,910519 up NM_006805 HNRPA0 A_24_P104407 2,5754514 down NM_145728 DMN A_23_P114172 2,215298 up NM_017752 TBC1D8B A_24_P944723 2,337541 down AK021676 AK021676 A_23_P83298 2,0287073 down NM_016307 PRRX2 A_23_P91076 2,126087 down CR621710 CR621710 A_23_P393620 2,5166104 down NM_006528 TFPI2 A_23_P125233 8,397155 down NM_001299 CNN1 A_23_P39076 2,1611593 down NM_006270 RRAS A_32_P112531 2,4351509 up THC2644853 THC2644853 A_32_P231143 2,2853582 up A_32_P231143 A_32_P231143 A_23_P125788 2,180168 down NM_152278 TCEAL7 A_24_P350644 2,788221 down ENST00000320547 ENST00000320547A_23_P135494 2,7082748 down NM_013943 CLIC4 A_23_P91390 2,0049605 down NM_000361 THBD A_23_P9836 2,6299324 up NM_004454 ETV5 A_24_P919989 2,730949 down BC015334 BC015334 A_23_P156861 2,3978844 down NM_012419 RGS17 A_24_P8888 2,730176 down NM_013310 C2orf27 A_24_P307695 2,23694 up NM_033402 LRRCC1 A_23_P152181 2,7868094 down NM_018119 POLR3E A_24_P384196 2,0133443 down A_24_P384196 A_24_P384196 A_24_P734720 2,915555 up NM_152523 CCNYL1 A_32_P748131 2,3853765 down AB075828 ZNF545 A_24_P118011 2,022074 up NM_001080459 LOC344405 A_23_P211167 2,2314525 up NM_004928 C21orf2 A_23_P157117 2,0386944 down NM_182898 CREB5 A_32_P214860 17,187544 down A_32_P214860 A_32_P214860 A_23_P39202 2,1070979 down NM_033520 C19orf33 A_23_P8452 2,1055996 down NM_001040167 LFNG A_32_P129950 3,5118623 up NM_001012754 RP11-50D16.3 A_23_P374767 2,3139017 up NM_015983 UBE2D4 A_23_P169978 3,8015633 up NM_020747 ZNF608 A_23_P14559 4,4129496 down NM_006871 RIPK3 A_23_P126623 2,2848954 up NM_002631 PGD A_23_P111583 10,7775 up NM_001001547 CD36 A_23_P216257 4,0209155 up NM_005079 TPD52 A_23_P95634 2,4157164 up NM_016599 MYOZ2 A_23_P202104 2,245021 up NM_005729 PPIF A_23_P30035 2,516427 up NM_018409 LRP2BP A_32_P139123 2,0835114 down THC2560068 THC2560068 A_24_P360269 2,1136343 down NM_003730 RNASET2 A_23_P67089 2,2061493 up NM_001024596 ZNF772 A_24_P548966 2,7441692 down ENST00000371655 RAB3B A_32_P103815 2,6426885 down AK056836 LOC150166 A_23_P320242 2,278252 up NM_152748 KIAA1324L A_23_P138655 3,6074963 up NM_057157 CYP26A1 A_24_P102362 2,0426023 down ENST00000320159 ZNF553

Page 22: Supplemental Figure 1 - Journal of Biological Chemistry€¦ · Supplemental Figure 1. GATA6 is essential for endothelial vessel-like structure formation. Representative images of

A_23_P144959 12,573453 down NM_004385 VCAN A_24_P41882 2,3418865 down NM_213636 PDLIM7 A_24_P524164 5,583976 down THC2667891 THC2667891 A_23_P201636 3,740636 down NM_005562 LAMC2 A_23_P415021 5,3353105 up NM_014033 METTL7A A_23_P82503 3,489256 down NM_001040152 PEG10 A_24_P924641 2,8738248 down THC2538610 THC2538610 A_23_P254654 7,6833744 down NM_004669 CLIC3 A_23_P87532 2,0976095 down NM_001002259 CAPRIN2 A_24_P772488 2,1435986 down AB046770 PLXNA4A A_32_P214503 2,3355696 up BC038512 BC038512 A_23_P502350 3,1681015 down NM_000635 RFX2 A_23_P47955 2,4786484 up NM_006187 OAS3 A_24_P68008 3,601961 down ENST00000294485 C1orf187 A_23_P51213 5,084444 down NM_152372 MYOM3 A_24_P122732 2,732147 down NM_173854 SLC41A1 A_24_P200000 3,7630076 down NM_182915 STEAP3 A_24_P393372 2,4239573 down AK098354 AK098354 A_23_P129322 2,3813257 up NM_002225 IVD A_24_P167668 2,3473654 down NM_000428 LTBP2 A_23_P132468 2,277288 down NM_003615 SLC4A7 A_32_P224727 2,6583438 down BE798911 BE798911 A_24_P686247 3,0889814 up DQ786238 DQ786238 A_24_P208703 2,195587 up NM_007177 FAM107A A_23_P78053 8,384329 up NM_030802 FAM117A A_23_P23855 2,0520732 up NM_032305 POLR3GL A_24_P221575 2,785578 up NM_014961 RUFY3 A_24_P227350 2,738067 down THC2495068 THC2495068 A_23_P169039 3,4964106 down NM_003068 SNAI2 A_23_P15004 2,6135032 up NM_139054 ADAMTS18 A_23_P31810 2,1482818 up NM_005195 CEBPD A_32_P228277 2,3591855 down N50366 N50366 A_24_P63522 4,016802 up NM_002130 HMGCS1 A_24_P149023 2,9858096 down NM_004866 SCAMP1 A_23_P90634 2,742431 up NM_152523 CCNYL1 A_23_P135826 2,1415179 down AK096342 ZNF93 A_23_P410859 2,4478512 down ENST00000252744 ZSWIM6 A_24_P413126 3,167863 down NM_020182 TMEPAI A_23_P156970 6,2706103 up NM_002402 MEST A_24_P64781 3,1201966 down NM_000899 KITLG A_23_P25935 2,028675 up NM_007176 C14orf1 A_23_P340019 10,745784 down NM_178844 NLRC3 A_23_P21376 2,0059354 up NM_012301 MAGI2 A_23_P149171 3,363776 up NM_018379 FAM63A A_24_P95070 9,741203 down ENST00000222543 TFPI2 A_23_P64280 2,7564166 up AY358681 AY358681 A_23_P28466 2,8488526 up NM_178821 WDR69 A_23_P167920 2,1435213 up NM_005618 DLL1 A_23_P200015 4,54861 up NM_174858 AK5 A_23_P150807 34,272182 up NM_003621 PPFIBP2 A_23_P379475 2,230983 up NM_014762 DHCR24 A_32_P55241 2,4230928 down NM_001007538 TMEM46 A_23_P108673 2,3862102 down NM_032181 TMEM166 A_24_P497235 2,2930124 down BC013389 BC013389 A_23_P373598 2,172714 down NM_002360 MAFK A_23_P27473 2,0447903 up NM_032488 CNFN

Page 23: Supplemental Figure 1 - Journal of Biological Chemistry€¦ · Supplemental Figure 1. GATA6 is essential for endothelial vessel-like structure formation. Representative images of

A_23_P216017 2,1081069 up NM_004901 ENTPD4 A_23_P209578 2,2219071 up NM_013445 GAD1 A_23_P119196 2,240546 down NM_016270 KLF2 A_23_P121956 4,2134485 down NM_017872 THG1L A_24_P228875 3,172718 up NM_004840 ARHGEF6 A_24_P306063 3,179285 down NM_020819 FAM135A A_24_P368575 3,005504 down NM_003615 SLC4A7 A_23_P41917 2,1145923 down NM_004272 HOMER1 A_24_P278299 2,0339777 up NM_024701 ASB13 A_32_P152437 6,4313645 down BC033829 BC033829 A_24_P192805 3,0858655 up NM_001007232 INCA A_23_P202327 5,321993 down NM_003474 ADAM12 A_23_P56746 2,387366 down NM_004460 FAP A_24_P195669 3,0448208 up AK074680 MYO15B A_24_P390403 2,0866115 down NM_015138 RTF1 A_32_P62145 4,080361 down BC013423 BC013423 A_32_P4778 2,068575 down THC2765857 THC2765857 A_23_P217379 2,627815 down NM_033641 COL4A6 A_23_P14508 2,2960954 down ENST00000256367 TTC9 A_23_P117104 7,041788 up BC032946 AQP5 A_24_P794447 2,2096562 up AK021552 LOC399959 A_23_P203994 2,230223 down NM_002813 PSMD9 A_24_P50368 3,5372066 up NM_001001786 BRCC2 A_23_P8653 3,1624148 up NM_001039706 FLJ21062 A_23_P116037 3,6751401 up NM_003273 TM7SF2 A_23_P163209 3,3889706 up NM_020396 BCL2L10 A_23_P13094 7,645859 down NM_002425 MMP10 A_23_P15889 6,712111 up NM_182511 CBLN2 A_24_P940576 2,6506853 down NM_020782 KLHDC5 A_32_P52282 2,410641 up NM_016371 HSD17B7 A_23_P382835 2,8696632 down NM_002563 P2RY1 A_23_P397376 3,9044185 down NM_005360 MAF A_32_P85593 2,2656305 down NM_194324 MGC39900 A_24_P261760 4,32433 up NM_005810 KLRG1 A_23_P31135 2,4952185 up BC000408 ACAT2 A_32_P35232 2,0098505 down ENST00000337530 KIAA1958 A_24_P374709 3,4852345 up NM_017415 KLHL3 A_23_P208788 2,0052893 down NM_033520 C19orf33 A_23_P134109 2,2685213 up NM_001431 EPB41L2 A_24_P778836 2,1712172 down NM_015659 RSL1D1 A_23_P20752 2,0972028 up NM_178432 CCRK A_23_P304682 2,694514 down ENST00000320378 ENST00000320378A_24_P2338 3,486926 up NM_022098 XPNPEP3 A_32_P34444 18,55273 down NM_025135 FHOD3 A_23_P72817 7,668936 up NM_020634 GDF3 A_24_P346859 4,223179 up A_24_P346859 A_24_P346859 A_23_P138574 2,8920703 down NM_001001976 ATE1 A_24_P90216 2,2609742 up NM_018490 LGR4 A_24_P8220 2,2696576 down BC001196 HS6ST1 A_23_P374862 2,3424633 down NM_000574 CD55 A_23_P113701 2,7310636 down NM_002607 PDGFA A_23_P79289 2,236703 up NM_014900 COBLL1 A_23_P126474 2,1598575 up NM_003145 SSR2 A_23_P144896 2,5259128 down NM_005451 PDLIM7 A_23_P258862 3,1386602 up NM_145341 PDCD4 A_24_P384851 2,2273147 down NM_001007559 SS18

Page 24: Supplemental Figure 1 - Journal of Biological Chemistry€¦ · Supplemental Figure 1. GATA6 is essential for endothelial vessel-like structure formation. Representative images of

A_24_P100301 4,4343605 up NM_017655 GIPC2 A_24_P918147 22,494812 down AK023391 AK023391 A_23_P69683 2,1225994 down NM_006323 SEC24B A_32_P113380 3,6272671 up THC2677659 THC2677659 A_23_P144369 2,3442059 up NM_153757 NAP1L5 A_32_P40288 2,41546 down NM_052913 KIAA1913 A_23_P404494 2,13974 down NM_002185 IL7R A_24_P365327 2,446097 down NM_015578 LSM14A A_24_P98210 2,1518471 up NM_012252 TFEC A_23_P121702 2,3977435 down NM_001014446 OCIAD2 A_32_P101031 3,9354813 down NM_144586 LYPD1 A_23_P202501 2,0816476 up NM_018363 C10orf59 A_24_P322867 2,4624474 down NM_004420 DUSP8 A_23_P160240 2,0876355 up NM_016361 ACP6 A_23_P19142 3,59628 down NM_004137 KCNMB1 A_24_P8575 2,3918166 up AB007928 OTUD3 A_23_P120667 2,5551596 down NM_021219 JAM2 A_23_P156826 4,0783205 down NM_032744 C6orf105 A_32_P74477 2,15648 up THC2609205 THC2609205 A_23_P159937 2,6975286 down NM_005629 SLC6A8 A_23_P135499 2,7919824 down NM_013943 CLIC4 A_23_P390518 2,9466488 up NM_003839 TNFRSF11A A_23_P217820 2,5948625 up NM_014762 DHCR24 A_32_P5628 2,1645496 up A_32_P5628 A_32_P5628 A_23_P10995 2,042086 up NM_014483 RBMS3 A_32_P223173 3,5180027 down THC2650095 THC2650095 A_32_P199429 5,301241 up THC2665663 THC2665663 A_24_P243749 3,3611248 up NM_002612 PDK4 A_23_P97112 7,1918306 up NM_000450 SELE A_23_P363878 2,8722029 up NM_144629 RFTN2 A_23_P156568 2,558026 up NM_057161 KLHDC3 A_24_P353103 2,077395 up NM_001007248 ZNF599 A_24_P115651 6,844202 down NM_145010 C10orf63 A_23_P145752 3,0144374 up NM_153620 HOXA1 A_32_P192842 2,8076308 down BM129308 BM129308 A_24_P399585 2,1178637 down NM_003021 SGTA A_23_P36408 2,2681203 up NM_022916 VPS33A A_23_P82814 9,887561 down NM_058229 FBXO32 A_23_P103110 2,170753 down NM_012323 MAFF A_23_P81529 3,8185554 up NM_002202 ISL1 A_24_P211106 2,8821037 up ENST00000382790 ENST00000382790A_23_P146943 2,7003956 down NM_001677 ATP1B1 A_23_P110362 2,2071252 down NM_021970 MAP2K1IP1 A_23_P351215 2,1925626 down NM_005414 SKIL A_23_P53866 2,1492903 up NM_020751 COG6 A_32_P87491 2,1334324 down U79293 U79293 A_23_P88184 2,0192578 up NM_018167 BTBD7 A_32_P131940 2,0641346 down NM_172020 POM121 A_23_P116264 2,152944 down NM_006176 NRGN A_24_P921321 4,130742 up BC019824 BC019824 A_24_P128163 4,694762 down BC030812 ADAMTS4 A_23_P390445 2,6191669 up NM_001080545 PPP1R1C A_23_P97553 3,9195807 up BX648708 KIAA0090 A_24_P384839 2,303591 up NM_002340 LSS A_24_P90597 6,176631 down NM_032849 C13orf33 A_23_P358714 2,7600293 up AY358366 KIAA1324

Page 25: Supplemental Figure 1 - Journal of Biological Chemistry€¦ · Supplemental Figure 1. GATA6 is essential for endothelial vessel-like structure formation. Representative images of

A_23_P364024 2,6232808 down NM_006851 GLIPR1 A_23_P98205 2,2977836 down NM_003654 CHST1 A_23_P80048 2,7309089 down NR_001442 FER1L4 A_23_P209298 2,16508 up BC032822 EPB41L5 A_23_P342910 3,2437751 up ENST00000328046 KLHL15 A_24_P85099 2,7988102 down NM_003483 HMGA2 A_24_P202555 2,3369424 down NM_015073 SIPA1L3 A_24_P921850 2,361678 up AK124470 AK124470 A_23_P33196 4,244336 up NM_000393 COL5A2 A_24_P12065 2,3099902 up AK092638 AK092638 A_23_P344555 2,0916867 down NM_006403 NEDD9 A_23_P200710 2,785059 up NM_002646 PIK3C2B A_23_P5435 2,1800017 up AY358993 KRTCAP3 A_23_P36689 3,1227338 up NM_006992 LRRC23 A_24_P272146 4,1813736 down BC067092 IGKC A_23_P154367 2,1006045 up NM_004226 STK17B A_23_P354170 2,335039 up NM_017861 PIGX A_23_P64785 4,6182446 up NM_152320 ZNF641 A_23_P20494 2,5169656 down NM_006096 NDRG1 A_24_P208595 2,6092813 up NM_053034 ANTXR1 A_23_P95672 2,2686105 up NM_006548 IGF2BP2 A_23_P113613 4,0553265 down NM_022842 CDCP1 A_23_P96599 2,2235715 down ENST00000372602 TMSL8 A_23_P170857 3,1734784 up NM_002182 IL1RAP A_24_P466590 2,348628 down BM692484 BM692484 A_32_P43855 2,4392898 down BX476711 BX476711 A_23_P501080 2,4216766 down NM_007139 ZNF92 A_23_P159305 4,537362 up NM_139215 TAF15 A_32_P149158 2,2197847 up THC2667632 THC2667632 A_23_P38732 3,1471336 down NM_001792 CDH2 A_23_P30050 2,4646482 up NM_006345 SLC30A9 A_24_P135769 2,3569624 up NM_198315 LOH11CR2A A_24_P329487 2,8332021 up NM_174911 FAM84B A_23_P103511 2,7614737 up ENST00000367932 ENST00000367932A_23_P215751 2,4496577 down NM_005000 NDUFA5