Supplemental Figure 1 · Supplemental Table 1 Kd (nM) Birinapant AVPI (Smac) cIAP1 BIR3
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Supplemental Figure 1
Transcript of Supplemental Figure 1 · Supplemental Table 1 Kd (nM) Birinapant AVPI (Smac) cIAP1 BIR3
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Supplemental Figure 1
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Supplemental Figure 2
A B
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Supplemental Figure 3A
B
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Supplemental Figure 4
F (p
g/m
L)
300
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500SK-OV-3EVSA-TA375HeLa
Secr
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F
100
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1 μM Birinapant No Treatment0
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Supplemental Figure 5
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Supplemental Figure 6
A
B
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Supplemental Figure 7
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Supplemental Table 1
Kd (nM)Birinapant AVPI (Smac)
cIAP1 BIR3 <1 2cIAP2 BIR3 36 20XIAP BIR3 45 130ML-IAP BIR <1 900
Kd, dissociation constant; cIAP, cellular inhibitor of apoptosis; XIAP, X-linked inhibitor of apoptosis; ML-IAP, melanoma inhibitor of apoptosis.