Nat. Med. 20, 87–92 (2014) Pharmacological and … · Nat. Med. 20, 87–92 (2014)...

35
Nat. Med. 20, 87–92 (2014) Pharmacological and genomic profiling identifies NF-κB–targeted treatment strategies for mantle cell lymphoma Rami Rahal, Mareike Frick, Rodrigo Romero, Joshua M Korn, Robert Kridel, Fong Chun Chan, Barbara Meissner, Hyo-eun Bhang, Dave Ruddy, Audrey Kauffmann, Ali Farsidjani, Adnan Derti, Daniel Rakiec, Tara Naylor, Estelle Pfister, Steve Kovats, Sunkyu Kim, Kerstin Dietze, Bernd Dörken, Christian Steidl, Alexandar Tzankov, Michael Hummel, John Monahan, Michael P Morrissey, Christine Fritsch, William R Sellers, Vesselina G Cooke, Randy D Gascoyne, Georg Lenz & Frank Stegmeier In the version of this supplementary file originally posted online, the name of the NIK pharmacological inhibitor used in Supplementary Figure 7 was incorrect. It should have been 4-[1-(2-aminopyrimidin-4-yl)-1H-1,3-benzodiazol-6-yl]-2-(1,3-thiazol-2-yl)but-3-yn-2-ol. The authors also added its biochemical IC 50 as 11 nM at 8 μM ATP. The error has been corrected in this file as of 7 February 2014. CORRECTION NOTICE

Transcript of Nat. Med. 20, 87–92 (2014) Pharmacological and … · Nat. Med. 20, 87–92 (2014)...

  • Nat. Med. 20, 8792 (2014)

    Pharmacological and genomic profiling identifies NF-Btargeted treatment strategies for mantle cell lymphomaRami Rahal, Mareike Frick, Rodrigo Romero, Joshua M Korn, Robert Kridel, Fong Chun Chan, Barbara Meissner, Hyo-eun Bhang, Dave Ruddy, Audrey Kauffmann, Ali Farsidjani, Adnan Derti, Daniel Rakiec, Tara Naylor, Estelle Pfister, Steve Kovats, Sunkyu Kim, Kerstin Dietze, Bernd Drken, Christian Steidl, Alexandar Tzankov, Michael Hummel, John Monahan, Michael P Morrissey, Christine Fritsch, William R Sellers, Vesselina G Cooke, Randy D Gascoyne, Georg Lenz & Frank Stegmeier

    In the version of this supplementary file originally posted online, the name of the NIK pharmacological inhibitor used in Supplementary Figure 7 was incorrect. It should have been 4-[1-(2-aminopyrimidin-4-yl)-1H-1,3-benzodiazol-6-yl]-2-(1,3-thiazol-2-yl)but-3-yn-2-ol. The authors also added its biochemical IC50 as 11 nM at 8 M ATP. The error has been corrected in this file as of 7 February 2014.

    CO R R E C T I O N N OT I C E

  • Nature Medicine doi:10.1038/nm.3435

  • ! " ! # $ % # & ' %

    ( ) *

    + , ! - % , . / 0 / , ! # 1 2 3 21 4 25 6 1 2 25 7 8 9 : ; ;3 4 23 < 2 3

    = 2 5 3 24 3 2> ? @ A B @ C D ? ? B E D ? F B @

    G 8 D 6 5 6 1 2 2< 6 1 2 2H I @

    1 2 3 21 4 25 6 1 2 25 7 8 9 : ; ;3 4 23 < 2 3

    = 2 5 3 24 3 2> ? @ A B @ C D ? ? B E D ? F B @

    G 8 D 6 5 6 1 2 2< 6 1 2 2H I @

    1 2 3 21 4 25 6 1 2 25 7 8 9 : ; ;3 4 23 < 2 3

    = 2 5 3 24 3 2> ? @ A B @ C D ? ? B E D ? F B @

    G 8 D 6 5 6 1 2 2< 6 1 2 2H I @

    1 2 3 21 4 25 6 1 2 25 7 8 9 : ; ;3 4 23 < 2 3

    = 2 5 3 24 3 2> ? @ A B @ C D ? ? B E D ? F B @

    G 8 D 6 5 6 1 2 2< 6 1 2 2H I @

    J KL MN O

    P QRS

    J KL MN O

    P QRS

    J KL MN O

    P QRS

    J KL MN O

    P QRS

    Nature Medicine doi:10.1038/nm.3435

  • ! " # $ ! % & ' ( )

    *

    + & , ' - . ( / $ 0 1 2 3 4 5 6 )

    *

    7 6 8 8 - 9 $ : 6 # )

    *

    : ! # 8 9 5 $ ! ; < ' 8 = ! ; < ' > ? )

    @ AB CD E

    F GHI

    @ AB CD E

    F GHI

    @ AB CD E

    F GHI

    @ AB CD E

    F GHI

    Nature Medicine doi:10.1038/nm.3435

  • ! " # $%&

    '(

    ) ') &) %) *) +) ,

    %&

    '(

    ) ') &) %) *) +

    - . / / 0 1 # $

    &'

    () ') &) %) *) +

    %2 0 3 4 5 6 3 7 8 9 - $

    %&

    '(

    ) ') &) %) *) +) ,

    : ; : 9 9 3 < $

    = >? @A B

    C DEF

    = >? @

    A BC DEF

    = >? @

    A BC DEF

    = >? @A B

    C DEF

    Nature Medicine doi:10.1038/nm.3435

  • ! "

    # $%&

    ! "

    # $%&

    ! "

    # $%&

    ! "

    # $%&

    Nature Medicine doi:10.1038/nm.3435

  • ! "

    # $%

    &' ()! *

    +# ,$+# $

    %

    "' -

    ! "# $%

    & .

    ! "# $%

    /",0! *+# ,$+# $

    %

    123 ! *+# ,$+# $

    %

    Nature Medicine doi:10.1038/nm.3435

  • Nature Medicine doi:10.1038/nm.3435

  • ! " #$ % & ' ( & " ) * +, " * - ./ & 0 1 % " *2 3 / " #

    4 1 5 " *6 7 8 +

    9 9 : 9 9 ; 9 : 9 9 < 9 : 9 9 = 9 : 9 9 > 9 : 9 ?

    ?

    9 : >

    9 : =

    9 : ? @

    A B C D E F GA B C D E F G

    H I C J K

    L M M K N O PL M M K N O >Q A R

    ST U VT U WT U XT U YT U ZT U [T U \T U ]T U S

    T S ] \ [ Z Y X W V S T

    ^ _` abc d_

    efgh

    bij k

    lm no

    L M M K N O PL M M K N O >Q A R

    T S ] \ [ Z Y X W V S T

    ST U VT U WT U XT U YT U ZT U [T U \T U ]T U S

    ^ _` abc d_

    efghbi

    j klm n

    o

    L M M

    p R A L Q

    q r s

    L M MK N O >

    L M MK N O PQ A R

    L M MK N O >

    L M MK N O PQ A R

    < = > ? @ H I C J K

    Nature Medicine doi:10.1038/nm.3435

  • Nature Medicine doi:10.1038/nm.3435

  • Nature Medicine doi:10.1038/nm.3435

  • Nature Medicine doi:10.1038/nm.3435

  • Nature Medicine doi:10.1038/nm.3435

  • Nature Medicine doi:10.1038/nm.3435

  • Nature Medicine doi:10.1038/nm.3435

  • Nature Medicine doi:10.1038/nm.3435

  • ! " # $

    % & % '

    ( % ( % )( % &( % '

    * + * + * +

    , - . , / 0 1 , / 0 1 '

    * + * + * + * + * + * +

    Nature Medicine doi:10.1038/nm.3435

  • Nature Medicine doi:10.1038/nm.3435

  • Nature Medicine doi:10.1038/nm.3435

  • Nature Medicine doi:10.1038/nm.3435

  • ! "

    # $ %

    Nature Medicine doi:10.1038/nm.3435

  • Nature Medicine doi:10.1038/nm.3435

  • ! "# $ % & ' ( ) * * + , -

    # $ % & ' ( . * ' / 0 1 2 * * 3 , - 4 ! "# $ % & ' ( & 5 3 6 ) -

    7 8 9 : 9 8 ; : < = ; > ?

    @ A B

    CCCCCCC

    D E F

    G

    G

    ! "# $ % & ' ( ) * * + , -

    7 8 9 : 9 8 7 : = ; 8 > ?

    @ H @I J K

    GGGGGG

    C

    C

    @ A BD E F

    " L M N N M ! O

    7 8 9 : 9 8 7 : = ; 8 > ?

    G

    GGGGGGP QRP SPR T

    UV

    WXUR Y

    Z [ \ ] ^_ E ] ` K

    a b ac d e

    a f gc h i j

    Nature Medicine doi:10.1038/nm.3435

  • ! " # ! $

    Nature Medicine doi:10.1038/nm.3435

  • ! ! " # $ % & ! ! " # $

    Nature Medicine doi:10.1038/nm.3435

  • ! "

    "

    # $ # % & # % &

    ' & % ' # # # &

    % & % &

    # $ # ' & % ' # # # &

    % % & # % &

    Nature Medicine doi:10.1038/nm.3435

  • Nature Medicine doi:10.1038/nm.3435