Evidence for the cure of HIV infection by CCR5Δ32/Δ32 stem cell transplantation

by Kristina Allers, Gero Hütter, Jörg Hofmann, Christoph Loddenkemper, Kathrin Rieger, Eckhard Thiel, and Thomas Schneider

BloodVolume 117(10):2791-2799

March 10, 2011

©2011 by American Society of Hematology

Peripheral CD4+ T cells have been efficiently restored and contain an increased proportion of activated/effector memory CD4+ T cells compared with healthy control patients.

Allers K et al. Blood 2011;117:2791-2799

©2011 by American Society of Hematology

The mucosal immune system has been efficiently repopulated with donor-derived CD4+ T cells.

Allers K et al. Blood 2011;117:2791-2799

©2011 by American Society of Hematology

CXCR4 surface expression on peripheral and mucosal CD4+ T cells is not impaired in the CCR5Δ32/Δ32 SCT patient.

Allers K et al. Blood 2011;117:2791-2799

©2011 by American Society of Hematology

Recovered peripheral and mucosal CD4+ T cells are susceptible to productive X4 HIV infection.

Allers K et al. Blood 2011;117:2791-2799

©2011 by American Society of Hematology

No evidence for residual HIV target cells of host origin in the liver and the brain.

Allers K et al. Blood 2011;117:2791-2799

©2011 by American Society of Hematology

Host macrophages were replaced with donor-derived cells during the course of immune reconstitution.

Allers K et al. Blood 2011;117:2791-2799

©2011 by American Society of Hematology