HEMICELL HT FOR BROILERS - Dutch Poultry Expo

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HEMICELL HT FOR BROILERS β-MANNANS IN VEGETABLE FEED ARE A HOT TOPIC. Trigger innate immune system 9 Increase gut viscosity 7 1 3 2 4 Viewed by body as pathogens (PAMP response) 2,3,10 Cause intestinal inflammation 8 WASTES UP TO $11.50/MT FEED Cause 3% loss of feed engery 2,3,10 β-mannans are strong anti-nutritive fibers. 4 Polysaccharide fibers typically with a mannose backbone & galactose sidechains 1 Found in most vegetable feed ingredients 5 such as soybean, sunflower and guar meals Highly soluble Not digestible by non-ruminant animals More harmful in challenge periods 6 Amount in typical broiler diets varies from 0.2% - 0.4%* * Depending on feed ingredients Adverse effects from β-mannan can be reversed. Hemicell™ (β-mannanase) is a health-focused, nutrient-sparing enzyme that breaks down β-mannans in various feedstuffs Reduces cost of feeding by using an energy matrix value of up to 90 kcal/kg 12,13 Improves Intestinal Integrity (I2) Index by 1% 14 Reduces severe foot pad lesions by 5% 14 β-mannans are immunogenic compounds that hurt your flock and your bottom line. 1 2 3 190312-HemicellHT-Brochure-Broilers.indd 1 12/03/19 19:45

Transcript of HEMICELL HT FOR BROILERS - Dutch Poultry Expo

HEMICELL™ HT FOR BROILERS

β-MANNANS IN VEGETABLE FEED ARE A HOT TOPIC.

Trigger innateimmune system9

Increase gut viscosity71 3

2 4 Viewed by body aspathogens (PAMP response)2,3,10

Cause intestinal inflammation8

WASTES UP TO $11.50/MT FEED

Cause 3% loss offeed engery2,3,10

β-mannans are strong anti-nutritive fibers.4

• Polysaccharide fibers typically with a mannose backbone & galactose sidechains1

• Found in most vegetable feed ingredients5 such as soybean, sunflower and guar meals

• Highly soluble

• Not digestible by non-ruminant animals

• More harmful in challenge periods6

• Amount in typical broiler diets varies from 0.2% - 0.4%* * Depending on feed ingredients

Adverse effects from β-mannan can be reversed.Hemicell™ (β-mannanase) is a health-focused, nutrient-sparing enzyme that breaks down β-mannans in various feedstuffs

• Reduces cost of feeding by using an energy matrix value of up to 90 kcal/kg12,13

• Improves Intestinal Integrity (I2) Index by 1%14

• Reduces severe foot pad lesions by 5%14

β-mannans are immunogenic compounds that hurt your flock and your bottom line.

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Hemicell™ Use RecommendationsHemicell™ HT is a unique, patented enzyme produced by fermentation of Paenibacillus lentus bacteria. The active ingredient is endo-1,4-β-Mannanase.

Use Hemicell™ HT in diets containing at least 0.2% soluble β-mannan.

Species: Broilers Turkeys Swine

Energy Reduction: Formulate Hemicell™ HT to spare up to90 kcal ME (63 kcal NE) per kg of complete feed

Recommended Inclusion:

PRODUCT (form) RECOMMENDED INCLUSION PER TONNE

OF COMPLETE FEED

Broilers Turkeys Weaned Pigs Pigs for Fattening

Hemicell™ HT (liquid)

Hemicell™ HT (dry)

90 ml 82 ml90 ml 80 ml

330 g 330 g 300 g 300 g

HEMICELL™ HT

WITHSTANDSpH FLUCTUATIONSOF THE DIGESTIVE

SYSTEM

WITHSTANDSHEAT FROM

FEED PELLETING

WITHSTANDSDESTRUCTIVE

FORCES OFGASTROINTESTINAL

PROTEASES

1 Whistler RL et al J Am Chem Soc 1957 6055 . “Galactomannan From Soy Bean Hulls.” J. Am. Chem. Soc. 79: 6055-6057.2 Spurlock ME J Anim Sci 1997 1773. “Regulation of Metabolism and Growth During Immune Challenge: An Overview of Cytokine Function.” J. Anim. Sci. 75: 1773-1783. 3 Gabler NK et al J Anim Sci 2008 E64. “Integrating the Immune System with the Regulation of Growth and Effi ciency.” J. Anim. Sci. 86: E64-E74.4 Anderson DM et al Poult Sci 2008 159. “Identifi cation of an Infl ammatory Compound for Chicks in Soybean Meal-II.” Poultry Science 2008; 87: 159.5 Ferrel J et al Poster Presented at the MidWest ASAS 2014. “Content of Soluble Non-Starch Polysaccharides β-mannan and Xylan in Legume Meals, Non-Legume Meals, and Cereal Grains or Cereal Grain by-products.” Poster presented at the MidWest ASAS - Journal Animal Science, 92 2014; n/a: 328.6 Hsiao HY et al Int Poult Sci Form 2004 1790. “Effi cacy of β-mannanase (Hemicell™) in Broiler Chickens Infected with Necrotic Enteritis.” International Scientifi c Forum, Abstract 120, The Southern Conference on Avian Diseases.7 Latham RE et al, 1 February 2018, Poultry Sci 2018 549. “Effi cacy of β-mannanase on Broiler Growth Performance and Energy Utilization in the Presence of Increasing Dietary Galactomannan.” Poultry Science, Volume 97, Issue 2.8 Ikegami S et al J Nutr 1990 353. “Effect of Viscous Indigestible Polysaccharides on Pancreatic-Biliary Secretion and Digestive Organs in Rats.” Journ. of Nutrition. 120: 353-360.   9 Geneic NO et al Int Poultry Sci Forum Georgia World Cong Center 2015 54. “Effect of Hemicell™ HT Enzyme on the Immune System of Chickens and their Performance.” International Poultry Scientifi c Forum.10 Klasing KC Br Poultry Sci 2007 525. “Nutrition and the Immune System.” Br. Poult. Sci. 48(5): 525-537.11 Hsiao, H-Y., Anderson, D.M., Liu, L., and Jackson, M. 2010. “A Heat-tolerant β-mannanase: Its Biochemical Properties and Effect on Broiler Growth Performance.” J. Anim. Sci. 88, E-Suppl. 2.12 van Eerden, E. et al, 2014. “Effect of Hemicell™ on Production Performance and Clinical Scores in Broiler Chickens.” Elanco DoF Evaluate effect of Hemicell™ HT 2013 Trial PPG-53. Report no. 1366.13 Knox, A. 2009. “To Evaluate the Effi cacy of Hemicell™-L and Hemicell™-HT in Broilers Fed on Pelleted Diets Based on Wheat and Soybean Meal.” ChemGen Corp Roslin-Chemgen Broiler Trial 12 Nov 2009 Trial code 2009/3018. Roslin Nutrition Ltd., Scotland. 14 Poulsen K et al DoF Effects of β-Mannanase 2018. “Effects of β-Mannanase on Intestinal Health Analyzed in 30 Experience from EMEA.” Elanco Animal Health. Data on fi le.

Pelleting process addsheat & moisture

Pelleting interfereswith enzymes

At 88°C, Hemicell™ HTretains 95% activity11

(Fig. A)

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Enzymes need time atoptimal pH to work.

The optimal pH ofHemicell™ HT matches intestinal pH (Fig. B)

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Hemicell™ HT demonstrated up to91% residual activity after one hourin conditions simulating thestomach/gizzard11 (Fig. C)

In 3 out of 4 treatments, theHemicell™ HT that survived the uppertract retained all of its activity inthe lower tract11

pH

Fig. A Fig. B Fig. CHemicell™ HT

(Fig. A) Hemicell™ HT

A unique & patented feed enzyme specially formulated for pelleted diets thatdefi es a gauntlet of external and internal threats

Elanco Animal HealthPapendorpseweg 83, 3528 BJ Utrecht, Nederland - Plantin en Moretuslei 1a, B-2018 Antwerpen, België [email protected] - www.elanco.com

HemicellTM HT β-mannanase: Versterker verteerbaarheid (zoötechnisch voedseladditief) met gegarandeerd minstens 160 miljoen eenheden endo-1,4-β-mannanase (EC 3.2.1.78) per kg pro-duct Paenibacillus lentus. Europees identifi catienummer: 4a29. Lees voor gebruik de product-informatie. Verantwoordelijke: BE: Eli Lilly Benelux N.V., division Elanco Animal Health, Markies-straat 1, 1000 Brussel (αBE2234), +32 3 334 30 00. NL: Elanco Animal Health, Division of Eli Lilly Nederland BV, Postbus 8580, 3503 RN Utrecht (αNL13196) +31 30 307 92 45

HemicellTM HT-L β-mannanase: Versterker verteerbaarheid (zoötechnisch voedseladditief) Gega-randeerd minstens 590.000 eenheden endo-1,4-β-mannanase (EC 3.2.1.78) per ml product Pae-nibacillus lentus. Europees identifi catienummer: 4a29. Lees voor gebruik de productinformatie.Verantwoordelijke: BE: Eli Lilly Benelux N.V., division Elanco Animal Health, Markiesstraat 1, 1000 Brussel (αBE2234), +32 3 334 30 00. NL: Elanco Animal Health, Division of Eli Lilly Nederland BV, Postbus 8580, 3503 RN Utrecht (αNL13196) +31 30 307 92 45

Hemicell, Elanco, and the diagonal bar logo are trademarks of Elanco or its affi liates. © 2018 Elanco or its affi liates.

PM-B

E-18

-002

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NL)

100%

90%

80%

70%

60%

50%

40%

30%

20%

10%

0%

% e

nzym

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Reaction incubation pH5.00 5.50 6.00 6.60 7.11 7.63 8.02

100%90%80%70%60%50%40%30%20%10%0%

% re

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Treatment 1 (pH 2.5) Treatment 2 (pH 3.0) Treatment 3 (pH 3.5) Treatment 4 (pH 4.0)

43.10%

83.40% 86.90% 91.20%

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