Expo virus final
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Evidence for the cure of HIV infection by CCR5Δ32/Δ32 stem cell transplantation by Kristina Allers, Gero Hütter, Jörg Hofmann, Christoph Loddenkemper, Kathrin Rieger, Eckhard Thiel, and Thomas Schneider Blood Volume 117(10):2791-2799 March 10, 2011 ©2011 by American Society of Hematology
Transcript of Expo virus final
Evidence for the cure of HIV infection by CCR5Δ32/Δ32 stem cell transplantation
by Kristina Allers, Gero Hütter, Jörg Hofmann, Christoph Loddenkemper, Kathrin Rieger, Eckhard Thiel, and Thomas Schneider
BloodVolume 117(10):2791-2799
March 10, 2011
©2011 by American Society of Hematology
Peripheral CD4+ T cells have been efficiently restored and contain an increased proportion of activated/effector memory CD4+ T cells compared with healthy control patients.
Allers K et al. Blood 2011;117:2791-2799
©2011 by American Society of Hematology
The mucosal immune system has been efficiently repopulated with donor-derived CD4+ T cells.
Allers K et al. Blood 2011;117:2791-2799
©2011 by American Society of Hematology
CXCR4 surface expression on peripheral and mucosal CD4+ T cells is not impaired in the CCR5Δ32/Δ32 SCT patient.
Allers K et al. Blood 2011;117:2791-2799
©2011 by American Society of Hematology
Recovered peripheral and mucosal CD4+ T cells are susceptible to productive X4 HIV infection.
Allers K et al. Blood 2011;117:2791-2799
©2011 by American Society of Hematology
No evidence for residual HIV target cells of host origin in the liver and the brain.
Allers K et al. Blood 2011;117:2791-2799
©2011 by American Society of Hematology
Host macrophages were replaced with donor-derived cells during the course of immune reconstitution.
Allers K et al. Blood 2011;117:2791-2799
©2011 by American Society of Hematology
