Cardiovascular events and CKD

Cardiorenal syndrome

Ιωάννης Γ. Γριβέας,MD,PhD

BIG

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“There are good grounds

but by no means a proven

case for suspecting excess

salt intake, probably

associated with reduced

potassium intake , in the

aetiology of hypetensionn

in Western-Type

communities “

RENAL SODIUM RETENTION

Pressure

Natriuresis

Ischemic

nephron-Reduced

Nephron number

Quabain

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7

…Η Μοριακήβιολογία τουσυστήματος είναιπιο περίπλοκηαπό ότιπιστεύαμε…

…Human reningene…

ΠΙΘΑΝΈΣ ΕΞΗΓΉΣΕΙΣ…

Ischemic nephrons

Increased

sympathetic drive

Defective

feedback

regulation of

the RAAS in the kidney

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Εξήγηση του φαινομένου

Abnormally regulated and rather fixed local level of tissue AII

ABNORMAL MODULATION

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