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Kiriakos P. Karkoulias, MD, PhD

Pulmonologist Lecturer of Pulmonary Medicine

Department of Medicine University of Patras

PATRAS, GREECE 2012

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TABLE OF CONTENTS Ι. GENERAL INFORMATION ........................................................................................................ 3

ΙΙ. EDUCATION – WORK EXPERIENCE ......................................................................................... 3

ΙΙΙ. CURRENT POSITION .............................................................................................................. 3

ΙV. PhD THESIS ........................................................................................................................... 3

V. FOREIGN LANGUAGES ........................................................................................................... 4

VI. PRIZES – HONORS – MEMBER OF SCIENTIFIC SOCIETIES ..................................................... 4

VII. CLINICAL EXPERIENCE .......................................................................................................... 4

VIII. EDUCATIONAL EXPERIENCE................................................................................................ 5

IX. SPEECHES – LECTURES .......................................................................................................... 6

X. BOOK CHAPTERS .................................................................................................................... 8

XI. PUBLICATIONS IN PEER-REVIEWED INTERNATIONAL JOURNALS ......................................... 9

ΧII. PAPERS UNDER REVIEW .................................................................................................... 13

ΧIΙI. PARTICIPATION IN INTERNATIONAL CONFERENCES ........................................................ 13

ΧΙV. PARTICIPATION IN GREEK CONFERENCES ........................................................................ 16

XV. IMPACT FACTORS OF PUBLISHED PAPERS ........................................................................ 17

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Ι. GENERAL INFORMATION SURNAME Karkoulias NAME Kiriakos FATHER’S NAME Pavlos DATE OF BIRTH 7 October 1969 PLACE OF BIRTH Patras, Greece HOME ADDRESS Lykaiou 8, 26331, Patras, Greece HOME NUMBER +30 2610 624152 MOBILE NUMBER +30 6944 690882 e-mail karkoulias@upatras.gr

ΙΙ. EDUCATION – WORK EXPERIENCE 1988-1996 Laurea, Department of Medicine, University of Padua, Italy 03/2000- 10/2001 Physician, Nephrology Unit, Evangelismos General Hospital of Athens 11/2001- 11/2006 Internship of Pulmonary Medicine, University Hospital of Patras 11-01-2007 Specialty of Pulmonary Medicine 03/2007 – 04/2009 Consultant Pulmonologist, Pulmonary Medicine Department,

University Hospital of Patras 05/2009 – 11/2009 Fellowship in Oncology Clinic, San Gerardo, Monza University Hospital

of Milan, Italy 07/2010 – today Lecturer of Pulmonary Medicine, Department of Medicine, University

of Patras

ΙΙΙ. CURRENT POSITION Lecturer of Pulmonary Medicine, Department of Medicine, University of Patras since July 2010 till today.

ΙV. PhD THESIS PhD Diploma in May 2008 with honors entitled: “Study of Erectile Dysfunction in patients with Chronic Obstructive Pulmonary Disease and oxygen desaturation during sleep”.

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V. FOREIGN LANGUAGES English Excellent knowledge Italian Excellent knowledge

VI. PRIZES – HONORS – MEMBER OF SCIENTIFIC SOCIETIES Prizes:

1st prize in the International Conference 7th State of the ART, Interdisciplinary review Course Athens 17-20 April 2003 for the study: ENDOTHELIN 1 IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND ASTHMA

Honors:

Guest Editor in Special Issue «Pulmonary Dysfunction in COPD» of the Journal “Pulmonary Medicine”, Hindawi Publishers.

Participation in the European Study of the European Respiratory Society (ERS) «COPD Audit» in 2011 as main research partner of the Pulmonary Medicine Department of University Hospital of Patras

Member of Scientific Societies:

Medical Association of Patras

Hellenic Society of Infectious Diseases

Hellenic Thoracic Society

Hellenic Bronchology Society

European Respiratory Society (ERS)

VII. CLINICAL EXPERIENCE

Physician, Nephrology Unit, Evangelismos General Hospital of Athens.

Internship of Pulmonary Medicine, University Hospital of Patras. Especially participated in the management of patients with sleep apnea syndrome, chronic obstructive pulmonary disease, bronchial asthma. Moreover, participation in interventional pulmonary medicine procedures, spirometry and cardiopulmonary exercise testing and polysomnography.

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Consultant Pulmonologist, Pulmonary Medicine Department, University Hospital of Patras. Especially participated in:

o Outpatient Unit of Pulmonary Medicine Department o Outpatient clinic of patients with COPD o Outpatient clinic of patients with bronchial asthma o Sleep laboratory o Interventional Bronchoscopy o Spirometry laboratory o Cardiopulmonary exercise testing laboratory

Fellowship in Oncology Clinic, San Gerardo, Monza University Hospital of Milan, Italy:

o Outpatient Unit of the Department o Outpatient clinic of patients with lung cancer o Participation in Medical Thoracoscopy in Cardiothoracic Surgery Unit

Lecturer of Pulmonary Medicine, Department of Medicine, University of Patras:

o Education of students and interns of Department of Internal Medicine o Education of students and interns of Department of Pulmonary

Medicine o Outpatient unit of Neuromuscular Diseases, Department of Neurology o Member of Oncology advisory board of University Hospital of Patras

VIII. EDUCATIONAL EXPERIENCE

During the specialty training from 2001 until 2006 I participated in the training of medical students in pulmonary medicine. At present, I am responsible for their training in Pulmonary medicine department of Patras University Hospital.

From academic year 2006-2007 up to now, I participate in the lectures of “Pulmonary Medicine” in the curriculum of Department of Medicine, University of Patras. Moreover, I am in charge of the education and training of clinical dexterities of medical students, together with other professors of our Department of Medicine.

From the academic year 2006-2007 until now, I participate actively in the training of interns in Pulmonary Medicine department, Medical School, University Hospital of Patras.

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Since academic year 2006-2007 I participate in: o Educational visits of the Internal Medicine department o Educational visits of the Pulmonary Medicine department o Educational program of the Urology department o Educational program of the Oncology department o Grand round organized by the Internal Medicine department o The Post-Graduate Course “Life Sciences Informatics”

Member of the committee for the candidate PhD students: o Giannikoulis Christos, “Study of the respiratory function using

cardiopulmonary exercise testing of patients with gastroesophangeal reflux disease”, Department of Medicine, Univesity of Patras, 2011.

o Kaparianos Alexandros, “Impact of the functional polymorphisms of the gene of endothelin-1 in the failure of the respiratory function in a Caucasian population”, Department of Medicine, Univesity of Patras, 2011.

o Sampsonas Fotios, ”Correlation of the pathogenesis of chronic obstructive pulmonary disease with polymorphisms and haplotypes of endothelin-1”, Department of Medicine, Univesity of Patras, 2011.

IX. SPEECHES – LECTURES

Speech in Grand Round of the Pulmonary Department, University Hospital of Patras, 6 December 2006 on “Respiratory Failure”.

Speech “Pulmonary Embolism – Lung cancer”, clinical tutorial in 13rd Greek Respiratory Conference, 2-5 December 2004.

Speech in the 10th Seminar of Pulmonary Medicine Department, 22-24 November 2006 in Patras “Sleep disorders and Erectile Dysfunction”.

Speech in the 10th Seminar of Pulmonary Medicine Department, 7-9 October 2005 “COPD and Erectile Dysfunction”.

Speech in the Seminar of Hellenic Bronchology Society “Sleep apnea syndrome and systemic disturbances”, March 2004.

Speech in the Seminar “New perspectives in pulmonary disease”, Pirgos General Hospital, June 2008.

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Speech in Grand Round of the Internal Medicine Department, University Hospital of Patras “Pulmonary Nocardiosis”, 2008 .

Speech in Pampelloponese Medical Conference “COPD, a systemic disease”, Patras, March 2009.

Speech in the Seminar “Neutropenia and fever”, Como, Italy, 2009.

Presentation of the Academic Production of Pulmonary Medicine Department in Greece, December 2010.

Speech in the Educational Program of the Hellenic Thoracic Society entitled “Presentation of interesting cases” with the presentation “A rare cause of hemoptysis”, Chest Diseases Hospital of Athens “Sotiria”, 2011.

Speech in Panhellenic Allergy Conference “Novel perspectives in respiratory allergy” with the subject “COPD and asthma”, Patras, 2011.

Speech in Scientific Symposium of the Hellenic Society of General Medicine “Cough”, Nafplion, 2011.

Speech in 7th Scientific Symposium of the Hellenic Society of General Medicine “Lung function tests in patients with respiratory dysfunction”, Loutraki 2011.

Speech “Co-morbidities in COPD and asthma”, Kalavrita 2012 in a meeting under the auspices of Hellenic Thoracic Society.

“Epidemiology of lung cancer among smokers and non-smokers”, Hellenic Anti-cancer Society, Patras, October 2012.

Speech “Urine loss in patients with sleep apnea syndrome”, 10th Pampelloponese Medical Conference, Nafplion, October 2012.

Speech “Correlation of the SF-36 questionnaire and AHI in patients with sleep apnea syndrome”, 10th Pampelloponese Medical Conference, Nafplion, October 2012.

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X. BOOK CHAPTERS

Participation under the guidance of Professor Kostas Spiropoulos in the translation of the book “Guide to Mechanical Ventilation and Intensive Respiratory Care” by Lynelle N.B. Pierce, Pasxalidis Publications, Athens.

Participation under the guidance of Professor Kostas Spiropoulos in the translation of the book “Current Diagnosis and Treatment” by Winfried J. Randerath, Solingen Bernd M. Sanner, Wuppertal Virend K. Somers, Rochester, Minn., Pasxalidis Publications, Athens.

Author of the 4th chapter “Surgical care of patients with chronic respiratory disease” in the book “Endoscopic Urology” pp. 116-30, Giourdas Publications, Athens.

Participation in the book “Pulmonary Medicine: Pathophysiology of respiratory disease”, Professor Kostas Spiropoulos, 2008.

Book: Data Mining for Biomarker Discovery Springer Optimization and Its Applications (ISBN 978-1-4614-2106-1) Chapter: Neuromuscular Alterations of Upper Airway Muscles in Patients with OSAS: Radiological and Histopathological Findings Authors: Panagis Drakatos, Dimosthenis Lykouras, Fotis Sampsonas, Kiriakos Karkoulias, Kostas Spiropoulos

“Presentation of interesting cases”, Hellenic Thoracic Society. Chapter “A rare cause of hemoptysis”, Athens, 2011.

Book: Gene Therapy / Book 2 (ISBN 980-953-307-690-9) Chapter: Gene therapy perspectives against diseases of the respiratory system Authors: Dimosthenis Lykouras, Kiriakos Karkoulias, Christos Tourmousoglou, Efstratios Koletsis, Kostas Spiropoulos and Dimitrios Dougenis

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XI. PUBLICATIONS IN PEER-REVIEWED INTERNATIONAL

JOURNALS

1. Karkoulias K, Lykouras D, Nanopoulou M, Tsiamita M, Iliopoulos P, Spiropoulos K. An unexpected pulmonary arterial aneurysm in a COPD patient. Acta Clin Belg. 2011 Sep-Oct;66(5):379-80.

2. Kaparianos A, Sampsonas F, Lykouras D, Efremidis G, Drakatos P, Karkoulias K, Gogos C, Spiropoulos K. Association of ET-1 gene polymorphisms with COPD phenotypes in a Caucasian population. Monaldi Arch Chest Dis. 2011 Jun;75(2):126-31.

3. Karkoulias K, Sampsonas F, Lykouras D, Duska M, Christofidou M, Marangos M, Spiropoulos K. An unexpected pulmonary infection in a patient with gastric tube interposition, reconstruction of the hypopharynx and gastric-hypopharyngeal anastomosis. Acta Clin Belg. 2011 Jan-Feb;66(1):60-2.

4. Sampsonas E, Lykouras D, Drakatos P, Moschopoulou A, Spiropoulos K, Karkoulias K. Endothelin-1 polymorphisms involved in impaired exercise tolerance in COPD patients. A pilot study. Eur Rev Med Pharmacol Sci. 2011 Feb;15(2):123-8.

5. Giannikoulis C, Karkoulias K, Thomopoulos K, Marangos M, Spiropoulos K, Nikolopoulou V. Patients with gastroesophageal reflux disease and respiratory manifestations do not present lung function disorders during cardiopulmonary exercise test. Dis Esophagus. 2011 Apr;24(3):189-93.

6. Sampsonas E, Kaparianos A, Tzelepi V, Zolota V, Karkoulias K, Tsiamita M, Mastronikolis N, Spiropoulos K. Miliary pattern due to occupational lung disease in a patient with laryngeal cancer. Eur Rev Med Pharmacol Sci. 2010 Jan;14(1):43-5.

7. Karkoulias K, Lykouras D, Sampsonas F, Drakatos P, Canova S, Tsoukalas G, Spiropoulos K. The role of Endothelin-1 in obstructive sleep apnea syndrome and pulmonary arterial hypertension: pathogenesis and Endothelin-1 antagonists. Curr Med Chem. 2010;17(11):1059-66.

8. Patouchas D, Sampsonas F, Papantrinopoulou D, Tsoukalas G, Karkoulias K, Spiropoulos K. Determinants of specific sensitization in flour allergens in workers in bakeries with use of skin prick tests. Eur Rev Med Pharmacol Sci. 2009 Nov-Dec;13(6):407-11.

9. Drakatos P, Lykouras D, Sampsonas F, Karkoulias K, Spiropoulos K. Targeting leukotrienes for the treatment of COPD? Inflamm Allergy Drug Targets. 2009 Sep;8(4):297-306.

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10. Mastronikolis NS, Papadas TA, Marangos M, Karkoulias KP, Tsamandas AC, Goumas PD. Tuberculosis of the parotid gland. Tuberk Toraks. 2009;57(1):84-8. 11.

11. Patouchas D, Efremidis G, Karkoulias K, Zoumbos N, Goumas P, Spiropoulos K. Lung function measurements in traditional bakers. Acta Biomed. 2008 Dec;79(3):197-203.

12. Lykouras D, Sampsonas F, Kaparianos A, Efremidis G, Karkoulias K, Tsoukalas G, Spiropoulos K. Pulmonary arterial hypertension: need to treat. Inflamm Allergy Drug Targets. 2008 Dec;7(4):260-9.

13. Karkoulias K, Habeos I, Charokopos N, Tsiamita M, Mazarakis A, Pouli A, Spiropoulos K. Hormonal responses to marathon running in non-elite athletes. Eur J Intern Med. 2008 Dec;19(8):598-601.

14. Karkoulias K, Tsitsaras H, Patouchas D, Sampsonas F, Likouras D, Kaparianos A, Spiropoulos K. The alcoholic lung disease: historical background and clinical features. Medicina (Kaunas). 2008;44(9):651-64.

15. Lykouras D, Sampsonas F, Kaparianos A, Karkoulias K, Spiropoulos K. Role and pharmacogenomics of TNF-alpha in asthma. Mini Rev Med Chem. 2008 Aug;8(9):934-42.

16. Georgopoulos NA, Saltamavros AD, Vervita V, Karkoulias K, Adonakis G, Decavalas G, Kourounis G, Markou KB, Kyriazopoulou V. Basal metabolic rate is decreased in women with polycystic ovary syndrome and biochemical hyperandrogenemia and is associated with insulin resistance. Fertil Steril. 2009 Jul;92(1):250-5.

17. Kaparianos A, Argyropoulou E, Sampsonas F, Karkoulias K, Tsiamita M, Spiropoulos K. Pulmonary complications in diabetes mellitus. Chron Respir Dis. 2008;5(2):101-8.

18. Lykouras D, Sampsonas F, Kaparianos A, Karkoulias K, Tsoukalas G, Spiropoulos K. Human genes in TB infection: their role in immune response. Monaldi Arch Chest Dis. 2008 Mar;69(1):24-31.

19. Papadas TA, Karkoulias KP, Mastronikolis NS, Sampsonas FL, Spiropoulos KB. Concurrent tonsillitis and pneumonia due to S. pyogenes. Clin Ter. 2008 Jan-Feb;159(1):33-4.

20. Karkoulias K, Sampsonas F, Kaparianos A, Tsiamita M, Tsoukalas G, Spiropoulos K. Urinothorax: an unexpected cause of pleural effusion in a patient with non-Hodgkin lymphoma. Eur Rev Med Pharmacol Sci. 2007 Nov-Dec;11(6):373-4.

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21. Karkoulias K, Perimenis P, Charokopos N, Efremidis G, Sampsonas F, Kaparianos A, Patouchas D, Tsiamita M, Spiropoulos K. Does CPAP therapy improve erectile dysfunction in patients with obstructive sleep apnea syndrome? Clin Ter. 2007 Nov-Dec;158(6):515-8.

22. Charokopos N, Leotsinidis M, Pouli A, Tsiamita M, Karkoulias K, Spiropoulos K. Periodic limb movement during sleep and chronic obstructive pulmonary disease. Sleep Breath. 2008 May;12(2):155-9.

23. Karkoulias K, Patouchas D, Alahiotis S, Tsiamita M, Vrodakis K, Spiropoulos K. Specific sensitization in wheat flour and contributing factors in traditional bakers. Eur Rev Med Pharmacol Sci. 2007 May-Jun;11(3):141-8.

24. Sampsonas F, Karkoulias K, Kaparianos A, Tsiamita M, Spiropoulos K. Pulmonary alveolar microlithiasis in a patient with rheumatic valvular heart disease. Am J Med Sci. 2007 Aug;334(2):128-30.

25. Sampsonas F, Archontidou MA, Salla E, Karkoulias K, Tsoukalas G, Spiropoulos K. Genetic alterations of glutathione S-transferases in asthma: do they modulate lung growth and response to environmental stimuli? Allergy Asthma Proc. 2007 May-Jun;28(3):282-6.

26. Karkoulias K, Charokopos N, Kaparianos A, Sampsonas F, Tsiamita M, Spiropoulos K. Aseptic femoral head necrosis in a patient receiving long term courses of inhaled and intranasal corticosteroids. Tuberk Toraks. 2007;55(2):182-5.

27. Charokopos N, Leotsinidis M, Tsiamita M, Karkoulias K, Spiropoulos K. Sleep apnea syndrome in a referral population in Greece: influence of social factors. Lung. 2007 Jul-Aug;185(4):235-40.

28. Sampsonas F, Kaparianos A, Lykouras D, Karkoulias K, Spiropoulos K. DNA sequence variations of metalloproteinases: their role in asthma and COPD. Postgrad Med J. 2007 Apr;83(978):244-50.

29. Perimenis P, Karkoulias K, Konstantinopoulos A, Perimeni PP, Katsenis G, Athanasopoulos A, Spyropoulos K. Sildenafil versus continuous positive airway pressure for erectile dysfunction in men with obstructive sleep apnea: a comparative study of their efficacy and safety and the patient's satisfaction with treatment. Asian J Androl. 2007 Mar;9(2):259-64.

30. Perimenis P, Konstantinopoulos A, Karkoulias K, Markou S, Perimeni P, Spyropoulos K. Sildenafil combined with continuous positive airway pressure for treatment of erectile dysfunction in men with obstructive sleep apnea. Int Urol Nephrol. 2007;39(2):547-52.

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31. Kaparianos A, Sampsonas F, Karkoulias K, Spiropoulos K. The metabolic aspects and hormonal derangements in obstructive sleep apnoea syndrome and the role of CPAP therapy. Eur Rev Med Pharmacol Sci. 2006 Nov-Dec;10(6):319-26.

32. Sampsonas F, Karkoulias K, Kaparianos A, Spiropoulos K. Genetics of chronic obstructive pulmonary disease, beyond a1-antitrypsin deficiency. Curr Med Chem. 2006;13(24):2857-73.

33. Kaparianos A, Sampsonas F, Karkoulias K, Spiropoulos K. Obstructive sleep apnoea syndrome and genes. Neth J Med. 2006 Sep;64(8):280-9.

34. Charokopos N, Tsiamita M, Karkoulias K, Koumoundourou D, Aletra C, Dougenis D, Spiropoulos K. Carcinoid tumour behind bronchiectasis. Monaldi Arch Chest Dis. 2006 Jun;65(2):110-3.

35. Perimenis P, Karkoulias K, Konstantinopoulos A, Alchanatis M, Perimeni PP, Athanasopoulos A, Spyropoulos K. The impact of long-term conventional treatment for overlap syndrome (obstructive sleep apnea and chronic obstructive pulmonary disease) on concurrent erectile dysfunction. Respir Med. 2007 Feb;101(2):210-6.

36. Charokopos N, Tsiamita M, Karkoulias K, Panagiota R, Dougenis D,

Spiropoulos K. Recurrent catamenial hemothorax. Monaldi Arch Chest Dis. 2004 Jul-Sep;61(3):177-9.

37. Karkoulias K, Tsiamita M, Prodromaki E, Spiropoulos K. An unusual presentation of tuberculosis. Monaldi Arch Chest Dis. 2004 Apr-Jun;61(2):131-2.

38. Karkoulias KP, Efremidis GK, Tsiamita MS, Trakada GP, Prodromakis EN, Nousi ED, Spiropoulos KB. Abnormal origin of the left common carotid artery by innominate artery: a case of enlargement mediastinum. Monaldi Arch Chest Dis. 2003 Jul-Sep;59(3):222-3.

39. Perimenis P, Karkoulias K, Markou S, Gyftopoulos K, Athanasopoulos A,

Barbalias G, Kiriazopoulou V, Spiropoulos K. Erectile dysfunction in men with obstructive sleep apnea syndrome: a randomized study of the efficacy of sildenafil and continuous positive airway pressure. Int J Impot Res. 2004 Jun;16(3):256-60.

40. Karkoulias K, Lykouras D, Karaivazoglou K, Drakatos P, Sampsonas F, Spiropoulos K, Assimakopoulos K. The impact of Obstructive Sleep Apnea Syndrome severity on physical functioning. [IN PRESS].

41. Akinosoglou K, Karkoulias K, Marangos M. Infectious complications in patients with lung cancer. [IN PRESS].

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ΧII. PAPERS UNDER REVIEW

1. Lykouras D, Karkoulias K, Patouchas D, Lakoumentas J, Sampsonas F, Tranou MK, Spiropoulos K. Experience and limited lighting may affect sleepiness of tunnel workers. [Under Review].

2. Theodoropoulos K, Lykouras D, Apollonatou V, Karkoulias K, Flordellis C, Tselios T, Spiropoulos K. Aldosterone and Obstructive Sleep Apnea Syndrome: Correlations and possibilities. [Under Review].

ΧIΙI. PARTICIPATION IN INTERNATIONAL CONFERENCES 4th INTERNATIONAL CONFERENCE ON ADVANVES IN PULMONARY REHABILITATION AND MANAGEMENT OF CHRONIC RESPIRATORY FAILURE, CRITICAL EVENTS IN COPD AND CRONIC RESPIRATORY FAILURE 19-22 MARCH 2003, STRESSA / ITALY 1. Georgia Trakada, Maria Tsiamita, George Efremidis, Eleni Prodromaki, Evangelia

Nousi, Kiriakos Karkoulias, Kostas Spiropoulos. Chronic Obstructive Pulmonary Disease and Lower Respiratory Tract Infections.

2. Georgia Trakada, Maria Tsiamita, Eleni Prodromaki, George Efremidis, Evangelia Nousi, Kiriakos Karkoulias, Kostas Spiropoulos. Prognostic factors for fatal outcome in Lower Respiratory Tract Infections.

3. Georgia Trakada, Maria Tsiamita, Eleni Prodromaki, George Efremidis, Evangelia Nousi, Kiriakos Karkoulias, Kostas Spiropoulos. Endothelin-1 in Chronic Obstructive Pulmoinary Disease and asthma.

4. Georgia Trakada, Maria Tsiamita, Eleni Prodromaki, George Efremidis, Evangelia Nousi, Kiriakos Karkoulias, Kostas Spiropoulos. Sleep and Endothelin 1 in Chronic Obstructive Pulmonary Disease.

EUROPEAN RESPIRATORY SOCIETY ANNUAL CONFERENCE 4-8 SEPTEMBER 2004, GLASCOW / UK 5. Kiriakos Karkoulias, Eleni Prodromaki, George Efremidis, Nikos Charokopos,

Kostas Spiropoulos. The efficacy of sidenafil and CPAP in men with obstructive sleep apnea syndrome and erectile dysfunction.

6. Haralabos Tsitsaras, Athanasia Katsoni, Eleni Prodromaki, Evagelia Nousi, Kiriakos Karkoulias, George Efremidis, Georgia Trakada, Maria Tsiamita, Kostas Spiropoulos. A retrospective evaluation of our bronchoscopy lub data in relation with lung cancer.

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EUROPEAN RESPIRATORY SOCIETY ANNUAL CONFERENCE 2-6 SEPTEMBER 2006, MUNICH / GERMANY 7. Nikos Charokopos, Kiriakos Karkoulias, Maria Tsiamita, Kostas Spiropoulos. The

occurrence of periodic limb movements during sleep in COPD Patients.

8. Kiriakos Karkoulias, Nikos Charokopos, PetrosPerimenis, MariaTsiamita, Kostas Spiropoulos. The impact of long-term conventional treatment for overlap syndrome (OSAS and COPD) on concurrent erectile dysfunction (ED).

9. Kiriakos Karkoulias, Nikos Charokopos, Alexandros Kaparianos, Fotios Sampsonas, Kostas Spiropoulos. A cross-over study of the efficacy of sildenafil in the treatment of erectileDysfunction (ED) in patients with OSA treated with CPAP.

10. Nikos Charokopos, Kiriakos Karkoulias, MariaTsiamita, Kostas Spiropoulos. The effects of high-flow oxygen on plasma endothelin-1 levels during Exercise in advanced COPD patients.

EUROPEAN RESPIRATORY SOCIETY ANNUAL CONFERENCE 4-8 OCTOBER 2008, BERLIN/GERMANY 11. Fotis Sampsonas, Dimosthenis Lykouras, Alexandros Kaparianos, Kiriakos

Karkoulias, Maria Tsiamita, Kostas Spiropoulos. Evaluation of the 3A/4A (134delA) and Lys198Asn genetic polymorphisms of the endothelin-1 gene and their association with lung hyperinflation.

13 STATE OF THE ART CONFERENCE 2-4 APRIL 2009, ATHENS/GREECE 12. Kiriakos Karkoulias, Fotis Sampsonas, Ioanna Roulia, Dimosthenis Lykouras,

Kostas Spiropoulos. Case of a very rare cause of haemoptysis in a 30-year-old male non-smoker.

13. Kostas Spiropoulos, Fotis Sampsonas, Dimosthenis Lykouras, Panaghs Drakatos, Kiriakos Karkoulias. Association between the +138/exlins/delA and Lys198Asn polymorphisms of the endothelin-1 gene and the development of COPD.

EUROPEAN MULTIDISCIPLINARY CONFERENCE ON THORACIC ONCOLOGY 1-3 MAY 2009, LUGANO/SWITZERLAND [Abstracts are included as a supplement in Lung Cancer, Volume 64, Supplement 1, May 2009]

14. Dimosthenis Lykouras, Skoura Aggeliki, Kiriakos Karkoulias, Kostas Spiropoulos.

Cytological results of patients undergone bronchoscopy in a referral population in Western Greece. European Multidisciplinary Conference on Thoracic Oncology (EMCTO). 1-3 May 2009. Lugano, Switzerland.

15. Dimosthenis Lykouras, Skoura Aggeliki, Fotis Sampsonas, Georgios Efremidis, Maria Tsiamita, Kiriakos Karkoulias, Kostas Spiropoulos. Cytological results of

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patients suffering from lung cancer in a referral population in Western Greece. European Multidisciplinary Conference on Thoracic Oncology (EMCTO). 1-3 May 2009. Lugano, Switzerland.

EUROPEAN RESPIRATORY SOCIETY ANNUAL CONFERENCE 16-21 SEPTEMBER 2009, VIENNA/AUSTRIA 16. Dimosthenis Lykouras, Kiriakos Karkoulias, Fotis Sampsonas, Skoura Aggeliki,

Kostas Spiropoulos. Cytological results of patients undergone bronchoscopy in a referral population in Western Greece between 2006-2008.

14 STATE OF THE ART CONFERENCE 18-19 JUNE 2010, ATHENS/GREECE 17. Dimosthenis Lykouras, Fotis Sampsonas, Alexandros Kaparianos, Kiriakos

Karkoulias, Kostas Spiropoulos. Association of Endothelin-1 polymorphisms to impaired exercise tolerance in COPD patients.

18. Fotis Sampsonas, Alexandros Kaparianos, Dimosthenis Lykouras, George Efremidis, Anna Antonacopoulou, Panagis Drakatos, Kiriakos Karkoulias, Haralabos Kalofonos, Charalambos Gogos, Kostas Spiropoulos. Correlation between emphysematous and non-emphysematous phenotypes of COPD and ET-1 gene polymorphisms.

19. Kiriakos Karkoulias, Dimosthenis Lykouras, Kostas Spiropoulos. The quality of life is strongly correlated to SaO2 and RDI in patients with OSAS.

20. Dimosthenis Lykouras, Maria Sargianou, Fotis Sampsonas, Panagis Drakatos, Angeliki Bellou, Magdalini-Konstantina Tranou, Maria Nanopoulou, Asimina Zania, Kiriakos Karkoulias, Kostas Spiropoulos. OSAS and Hospital Anxiety Depression Scale: preliminary data of a referral population.

INTERNATIONAL CONFERENCE ON BIOMEDICAL DATA & KNOWLEDGE MINING: TOWARDS BIOMARKER DISCOVERY 7-9 JULY 2010, CHANIA/GREECE 21. Panagis Drakatos, Dimosthenis Lykouras, Fotis Sampsonas, Kostas Spiropoulos,

Kiriakos Karkoulias. Up to date imaging evaluation of the upper airway in patients with OSAS.

EUROPEAN RESPIRATORY SOCIETY ANNUAL CONFERENCE 18-22 SEPTEMBER 2010, BARCELONA/SPAIN 22. Dimosthenis Lykouras, Fotis Sampsonas, Alexandros Kaparianos, Kiriakos

Karkoulias, Kostas Spiropoulos. Endothelin-1 polymorphism involved in the impaired exercise tolerance in COPD patients: a precursor of pulmonary hypertension?

23. Fotis Sampsonas, Alexandros Kaparianos, Dimosthenis Lykouras, George Efraimidis, Anna Antonacopoulou, Panagis Drakatos, Kiriakos Karkoulias,

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Haralabos Kalofonos, Charalambos Gogos, Kostas Spiropoulos. Association of ET-1 gene polymorphisms with emphysematous and non-emphysematous phenotypes in a COPD Caucasian population.

1ST SLEEP AND BREATHING CONFERENCE EUROPEAN RESPIRATORY SOCIETY (ERS) and EUROPEAN SLEEP RESEARCH SOCIETY (ESRS) 31 MARCH-2 APRIL 2011, PRAGUE/CZECH REPUBLIC 24. Dimosthenis Lykouras, Kiriakos Karkoulias, Katerina Karaivazoglou, Maria

Sargianou, Angeliki Bellou, Panagis Drakatos, Maria Nanopoulou, Konstantinos Assimakopoulos, Kostas Spiropoulos. Correlation between the SF-36 questionnaire and the SaO2 and RDI in patients with Obstructive Sleep Apnea.

25. Kiriakos Karkoulias, Dimosthenis Lykouras, Katerina Karaivazoglou, Maria Sargianou, Magdalini-Konstantina Tranou, Maria Nanopoulou, Asimina Zania, Panagis Drakatos, Konstantinos Asimakopoulos, Kostas Spiropoulos. The correlation between OSAS and the Hospital Anxiety Depression Scale.

14TH ANNUAL SCIENTIFIC MEETING OF THE EUROPEAN ASSOCIATION FOR CONSULTATION-LIAISON PSYCHIATRY AND PSYCHOSOMATICS 30 JUNE-2 JULY 2011, BUDAPEST/HUNGARY 26. Kiriakos Karkoulias, Dimosthenis Lykouras, T Hyphantis,Katerina Karaivazoglou,

Panagis Drakatos, Fotis Sampsonas,Kostas Spiropoulos, Kostas Assimakopoulos. The impact of obstructive sleep apnea syndrome severity on patients’ quality of life.

EUROPEAN RESPIRATORY SOCIETY ANNUAL CONFERENCE 1-5 SEPTEMBER 2012, VIENNA/AUSTRIA 27. Dimosthenis Lykouras, Maria Sargianou, Kiriakos Karkoulias, Fotios Sampsonas,

Angeliki Skoura, Kleanthis Theodoropoulos, Apostolos Voulgaridis, Kostas Spiropoulos. Enuresis in Obstructive Sleep Apnea Syndrome patients.

28. Kiriakos Karkoulias, Dimosthenis Lykouras, Dimitrios Patouchas, Maria Sargianou, Fotios Sampsonas, Evanthia Faliagka, Athanasios Tsakalidis, Kostas Spiropoulos. Study of daytime sleepiness among tunnel workers on rotating schedule.

ΧΙV. PARTICIPATION IN GREEK CONFERENCES I have participated in 15 Greek Conferences on Pulmonary Medicine and Multidisciplinary Conferences with 52 posters and oral presentations. One of the presentations is illustrated below.

17

XV. IMPACT FACTORS OF PUBLISHED PAPERS

Names Title Journal Citations Impact Factor

Karkoulias, K., Lykouras, D., Nanopoulou, M., Tsiamita, M., Iliopoulos, P., Spiropoulos, K.

An unexpected pulmonary arterial aneurysm in a copd patient

(2011) Acta Clinica Belgica, 66 (5), pp. 379-380

0,596

Kaparianos, A., Sampsonas, F., Lykouras, D., Efremidis, G., Drakatos, P., Karkoulias, K., Gogos, C., Spiropoulos, K.

Association of ET-1 gene polymorphisms with COPD phenotypes in a Caucasian population

(2011) Monaldi Archives for Chest Disease - Pulmonary Series, 75 (2), pp. 126-131

-

Karkoulias, K., Sampsonas, F., Lykouras, D., Duska, M., Christofidou, M., Marangos, M., Spiropoulos, K.

An unexpected pulmonary infection in a patient with gastric tube interposition, reconstruction of the hypopharynx and gastric-hypopharyngial anastomosis

(2011) Acta Clinica Belgica, 66 (1), pp. 60-62

0,596

Sampsonas, F., Lykouras, D., Drakatos, P., Moschopoulou, A., Spiropoulos, K., Karkoulias, K.

Endothelin-1 polymorphisms involved in impaired exercise tolerance in COPD patients. A pilot study

(2011) European Review for Medical and Pharmacological Sciences, 15 (2), pp. 123-128

1,040

Giannikoulis, C., Karkoulias, K., Thomopoulos, K., Marangos, M., Spiropoulos, K., Nikolopoulou, V.

Patients with gastroesophageal reflux disease and respiratory manifestations do not present lung function disorders during cardiopulmonary exercise test

(2011) Diseases of the Esophagus, 24 (3), pp. 189-193

Cited 1 time

1,814

Sampsonas, F., Kaparianos, A., Tzelepi, V., Zolota, V., Karkoulias, K., Tsiamita, M., Mastronikolis, N., Spiropoulos, K.

Miliary pattern due to occupational lung disease in a patient with laryngeal cancer

(2010) European Review for Medical and Pharmacological Sciences, 14 (1), pp. 43-45

1,040

Karkoulias, K., Lykouras, D., Sampsonas, F., Drakatos, P., Canova, S., Tsoukalas, G., Spiropoulos, K.

The role of endothelin-1 in obstructive sleep apnea syndrome and pulmonary arterial hypertension: pathogenesis and endothelin-1 antagonists

(2010) Current Medicinal Chemistry, 17 (11), pp. 1059-1066

Cited 5 times

4,859

18

Patouchas, D., Sampsonas, F., Papantrinopoulou, D., Tsoukalas, G., Karkoulias, K., Spiropoulos, K.

Determinants of specific sensitization in flour allergens in workers in bakeries with use of skin prick tests

(2009) European Review for Medical and Pharmacological Sciences, 13 (6), pp. 407-411

Cited 2 times

1,040

Drakatos, P., Lykouras, D., Sampsonas, F., Karkoulias, K., Spiropoulos, K.

Targeting leukotrienes for the treatment of COPD?

(2009) Inflammation and Allergy - Drug Targets, 8 (4), pp. 297-306

Cited 4 times

3,340

Mastronikolis, N.S., Papadas, T.A., Marangos, M., Karkoulias, K.P., Tsamandas, A.C., Goumas, P.D.

Tuberculosis of the parotid gland

(2009) Tuberkuloz ve Toraks, 57 (1), pp. 84-88

Cited 2 times

-

Patouchas, D., Efremidis, G., Karkoulias, K., Zoumbos, N., Goumas, P., Spiropoulos, K.

Lung function measurements in traditional bakers

(2008) Acta Biomedica de l'Ateneo Parmense, 79 (3), pp. 197-203

Cited 2 times

-

Lykouras, D., Sampsonas, F., Kaparianos, A., Efremidis, G., Karkoulias, K., Tsoukalas, G., Spiropoulos, K.

Pulmonary arterial hypertension: Need to treat

(2008) Inflammation and Allergy - Drug Targets, 7 (4), pp. 260-269

Cited 7 times

3,340

Karkoulias, K., Habeos, I., Charokopos, N., Tsiamita, M., Mazarakis, A., Pouli, A., Spiropoulos, K.

Hormonal responses to marathon running in non-elite athletes

(2008) European Journal of Internal Medicine, 19 (8), pp. 598-601

Cited 9 times

2,000

Karkoulias, K., Tsitsaras, H., Patouchas, D., Sampsonas, F., Likouras, D., Kaparianos, A., Spiropoulas, K.

The alcoholic lung disease: historical background and clinical features

(2008) Medicina, 44 (9), pp. 651-664

Cited 3 times

-

Lykouras, D., Sampsonas, F., Kaparianos, A., Karkoulias, K., Spiropoulos, K.

Role and pharmacogenomics of TNF-α in asthma

(2008) Mini-Reviews in Medicinal Chemistry, 8 (9), pp. 934-942

Cited 4 times

2,528

Georgopoulos, N.A., Saltamavros, A.D., Vervita, V., Karkoulias, K., Adonakis, G., Decavalas, G., Kourounis, G., Markou, K.B., Kyriazopoulou, V.

Basal metabolic rate is decreased in women with polycystic ovary syndrome and biochemical hyperandrogenemia and is associated with insulin resistance

(2009) Fertility and Sterility, 92 (1), pp. 250-255

Cited 4 times

3,775

19

Kaparianos, A., Argyropoulou, E., Sampsonas, F., Karkoulias, K., Tsiamita, M., Spiropoulos, K.

Pulmonary complications in diabetes mellitus

(2008) Chronic Respiratory Disease, 5 (2), pp. 101-108

Cited 6 times

1,519

Lykouras, D., Sampsonas, F., Kaparianos, A., Karkoulias, K., Tsoukalas, G., Spiropoulos, K.

Human genes in TB infection: Their role in immune response

(2008) Monaldi Archives for Chest Disease - Pulmonary Series, 69 (1), pp. 24-31

Cited 12 times

-

Papadas, T.A., Karkoulias, K.P., Mastronikolis, N.S., Sampsonas, F.L., Spiropoulos, K.B.

Concurrent tonsillitis and pneumonia due to S. pyogenes

(2008) Clinica Terapeutica, 159 (1), pp. 33-34

0,266

Karkoulias, K., Sampsonas, E., Kaparianos, A., Tsiamita, M., Tsoukalas, G., Spiropoulos, K.

Urinothorax: An unexpected cause of pleural effusion in a patient with non-Hodgkin lymphoma

(2007) European Review for Medical and Pharmacological Sciences, 11 (6), pp. 373-374

Cited 1 time

1,040

Karkoulias, K., Perimenis, P., Charokopos, N., Efremidis, G., Sampsonas, F., Kaparianos, A., Patouchas, D., Tsiamita, M., Spiropoulos, K.

Does CPAP therapy improve erectile dysfunction in patients with obstructive sleep apnea syndrome?

(2007) Clinica Terapeutica, 158 (6), pp. 515-518

Cited 7 times

0,266

Charokopos, N., Leotsinidis, M., Pouli, A., Tsiamita, M., Karkoulias, K., Spiropoulos, K.

Periodic limb movement during sleep and chronic obstructive pulmonary disease

(2008) Sleep and Breathing, 12 (2), pp. 155-159

Cited 2 times 1,839

Karkoulias, K., Patouchas, D., Alahiotis, S., Tsiamita, M., Vrodakis, K., Spiropoulos, K.

Specific sensitization in wheat flour and contributing factors in traditional bakers

(2007) European Review for Medical and Pharmacological Sciences, 11 (3), pp. 141-148

Cited 1 time

1,040

Sampsonas, F., Karkoulias, K., Kaparianos, A., Tsiamita, M., Spiropoulos, K.

Pulmonary alveolar microlithiasis in a patient with rheumatic valvular heart disease

(2007) American Journal of the Medical Sciences, 334 (2), pp. 128-130

Cited 1 time

1,391

Sampsonas, F., Archontidou, M.-A., Salla, E., Karkoulias, K., Tsoukalas, G., Spiropoulos, K.

Genetic alterations of glutathione S-transferases in asthma: Do they modulate lung growth and response to environmental stimuli?

(2007) Allergy and Asthma Proceedings, 28 (3), pp. 282-286

Cited 7 times

2,170

Karkoulias, K., Charokopos, N., Kaparianos, A., Sampsonas, F., Tsiamita, M., Spiropoulos, K.

Aseptic femoral head necrosis in a patient receiving long term courses of inhaled and intranasal corticosteroids

(2007) Tuberkuloz ve Toraks, 55 (2), pp. 182-185

Cited 3 times

-

20

Charokopos, N., Leotsinidis, M., Tsiamita, M., Karkoulias, K., Spiropoulos, K.

Sleep apnea syndrome in a referral population in Greece: Influence of social factors

(2007) Lung, 185 (4), pp. 235-240

Cited 1 time 1,899

Sampsonas, F., Kaparianos, A., Lykouras, D., Karkoulias, K., Spiropoulos, K.

DNA sequence variations of metalloproteinases: Their role in asthma and COPD

(2007) Postgraduate Medical Journal, 83 (978), pp. 244-250

Cited 8 times

1,939

Perimenis, P., Konstantinopoulos, A., Karkoulias, K., Markou, S., Perimeni, P., Spyropoulos, K.

Sildenafil combined with continuous positive airway pressure for treatment of erectile dysfunction in men with obstructive sleep apnea

(2007) International Urology and Nephrology, 39 (2), pp. 547-552

Cited 10 times

1,471

Perimenis, P., Karkoulias, K., Konstantinopoulos, A., Perimeni, P.P., Katsenis, G., Athanasopoulos, A., Spyropoulos, K.

Sildenafil versus continuous positive airway pressure for erectile dysfunction in men with obstructive sleep apnea: A comparative study of their efficacy and safety and the patient's satisfaction with treatment

(2007) Asian Journal of Andrology, 9 (2), pp. 259-264

Cited 11 times

1,521

Kaparianos, A., Sampsonas, F., Karkoulias, K., Spiropoulos, K.

The metabolic aspects and hormonal derangements in obstructive sleep apnoea syndrome and the role of CPAP therapy

(2006) European Review for Medical and Pharmacological Sciences, 10 (6), pp. 319-326

Cited 1 time

1,040

Sampsonas, F., Karkoulias, K., Kaparianos, A., Spiropoulos, K.

Genetics of chronic obstructive pulmonary disease, beyond a1-antitrypsin deficiency

(2006) Current Medicinal Chemistry, 13 (24), pp. 2857-2873

Cited 25 times

4,859

Kaparianos, A., Sampsonas, F., Karkoulias, K., Spiropoulos, K.

Obstructive sleep apnoea syndrome and genes

(2006) Netherlands Journal of Medicine, 64 (8), pp. 280-289

Cited 13 times

2,072

Charokopos, N., Tsiamita, M., Karkoulias, K., Koumoundourou, D., Aletra, C., Dougenis, D., Spiropoulos, K.

Carcinoid tumour behind bronchiectasis

(2006) Monaldi Archives for Chest Disease - Pulmonary Series, 65 (2), pp. 110-113.

-

21

Perimenis, P., Karkoulias, K., Konstantinopoulos, A., Alchanatis, M., Perimeni, P.P., Athanasopoulos, A., Spyropoulos, K.

The impact of long-term conventional treatment for overlap syndrome (obstructive sleep apnea and chronic obstructive pulmonary disease) on concurrent erectile dysfunction

(2007) Respiratory Medicine, 101 (2), pp. 210-216.

Cited 7 times

2,475

Charokopos, N., Tsiamita, M., Karkoulias, K., Panagiota, R., Dougenis, D., Spiropoulos, K.

Recurrent catamenial hemothorax

(2004) Monaldi Archives for Chest Disease - Pulmonary Series, 61 (3), pp. 177-179

Cited 1 time

-

Karkoulias, K., Tsiamita, M., Prodromaki, E., Spiropoulos, K.

An unusual presentation of tuberculosis

(2004) Monaldi Archives for Chest Disease - Pulmonary Series, 61 (2), pp. 131-132

Cited 1 time

-

Karkoulias, K.P., Efremidis, G.K., Tsiamita, M.S., Trakada, G.P., Prodromakis, E.N., Nousi, E.D., Spiropoulos, K.B.

Abnormal origin of the left common carotid artery by innominate artery: A case of enlargement mediastinum

(2003) Monaldi Archives for Chest Disease, 59 (3), pp. 222-223

Cited 1 time

-

Perimenis, P., Karkoulias, K., Markou, S., Gyftopoulos, K., Athanasopoulos, A., Barbalias, G., Kiriazopoulou, V., Spiropoulos, K.

Erectile dysfunction in men with obstructive sleep apnea syndrome: A randomized study of the efficacy of sildenafil and continuous positive airway pressure

(2004) International Journal of Impotence Research, 16 (3), pp. 256-260.

Cited 18 times

3,200

ΣΥΝΟΛΟ 181 55,968

According to Scopus h-factor = 8.