S&Z training 25 april 2012

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  • 1. Selenium + ZincPharma Nord Training 25th April, 2012

2. Whats in Selenium + Zinc Pharma Nord?Each tablet contains: %RDAVitamin B6 (pyridoxine) 2 mg 100 %Vitamin C90 mg 150 %Vitamin E15 mg 150 %Zinc 15 mg 100 %Selenium (organic)100 gN/A 3. Do we need to supplement Selenium andZinc?Selenium (Se) is generally quite low in European soils.Traditionally, European supplies of flour came fromNorth America, where levels of Selenium are muchhigher, no longer the case. It is very easy to bedeficient in selenium.Zinc (Zn) is very commonly deficient in typical Westerndiets.Present in foods like shellfish, leafy greens, grains andnuts.Our consumption of organ meats and shellfish is notparticularly high Oxalic & phytic acid present in greens,wholegrains and seeds can interfere with our ability toabsorb nutrients such as Zinc, unless soakedovernight. 4. Why do we need Selenium? Selenium functions primarily as a component of the antioxidant enzyme glutathione peroxidase, which works with Vitamin E in preventing free radical damage to cell membranes. 5. How does it function as an antioxidant? Selenium donates an electron to the unstable free radical. Zinc, Vitamin C, Vitamin E and B6 all serve to regenerate each other, so the antioxidant complex remains stable, thus protecting our cells and tissue from damage. 6. Where can we get Selenium?Food Sources:Selenium content of food is highly variable because it depends soheavily on soil conditions. In fact, some researchers have concluded that itis not possible to create a valid list of foods and their seleniumcontent for this very reason.Grown or raised under ideal soil conditions, brazil nuts, salmon,scallops, chicken, eggs, shiitake mushrooms, lamb, barley, andturkey are excellent sources of selenium. 7. What does Selenium do?Selenium is metabolised andincorporated into selenoproteins.Some of these selenoproteins havebeen identified as havingantioxidative activity, while othershave structural and transportfunctions includingMaintaining cell membrane integrity, modulating fatty acid synthesis,modulating inflammation, protecting developing sperm cells fromoxidative damage, modulating sperm maturation, production andregulation of active thyroid hormone, regeneration of antioxidantsystems, protecting endothelial cells from oxidative stress,metabolism of skeletal and cardiac muscle, protection of prostatecells from development of carcinoma 8. How does Se affect our cancer risk?In 1984 the Food & Nutrition Board warned that Low Selenium intakeor decreased Se concentrations in the blood are associated withincreased risk of cancer in humans.A large body of scientific evidence demonstrates that cancer mortalityincreases when dietary intake of Se is suboptimal. Researchers havefound low levels of Se & GPx in the blood of subjects suffering fromvarious forms of cancer.Anti-cancer effects of Se are more significant in men than in women andare most important in the prevention of respiratory and gastrointestinaltract cancers.Pharma Nord has been involved in cancer prevention research for manyyears, using the PN Se yeast...INSERT MORE HERE 9. How does Se affect our immune health?Selenium, in its vital role in GPx affects all components of theimmune system.Deficiency of Se results in depressed immune function, and inhibitsresistance to infection as a result of impaired white blood cell and thymusfunction.A study where individuals with normal blood Se levels were given 200mcg/day, resulting in 118% increase in the ability to kill tumor cells and 82.3%increase in activity of a white blood cell known as a natural killer cellwhich kills cacner cells and microorganisms.This study did not result in significant changes in blood Se levels,but do indicate that the immune enhancing effects of Se in humansrequire supplementation above normal dietary intake. 10. How does Se affect our cardiovascularhealth?Se supplementation, like anyantioxidant, appears to offerprotection against heart disease andstrokes particularly due to theeffects on GPx activity.Also Se supplementation increases theradio of HDL to LDL and inhibits plateletaggregation, resulting in better bloodflow and a lower chance of clots.Se seems to offer protection insmokers more than any othergroup! 11. How does Se affect inflammatoryconditions?Se & GPx levels are low inpatients with RA, eczema,psoriasis and most likely lowin most inflammatoryconditions. Because free radicals, prostaglandins & oxidants cause much of the damage to tissues seen in RA, a Sedeficiency results in even more significant damage, due to low levels ofGPx.Clinical studies havent clearly demonstrated the Se supplementationalone improves signs and symptoms of RA, but one study indicatedthat Se combined with Vitamin E (as it is in Selenium+Zinc PharmaNord) does provide significant benefit. 12. How does Se affect fertility? Selenium has a number of functions in terms of fertility. The main one is as an antioxidant, protecting sperm and egg from free radical damage and therefore improving the health male and female reproductive units. The various selenoproteins that selenium forms alsofunction as a part of the structural base of mature sperm.Studies have shown that supplementation with selenium and vitamin Edecrease semen oxidative load and increase sperm cell motility.Low intake of selenium also seems to be associated with a greaterrisk of preeclampsia. 13. What happens if we dont get enough? Deficiency symptoms forselenium are difficult todetermine andcontroversial in theresearch literature. With prolonged and severedeficiency, symptomsclearly centre around twoof the body areas whereoxidative stress is knownto take its toll: the heartand the joints Low levels of Se are linked to a higher risk for cancer,cardiovascular disease, inflammatory diseases and otherconditions associated with increased free radical damage,including premature aging. 14. What kind of Selenium is best tosupplement?Selenium is available in several different forms;Inorganic salts like sodium selenite are less effectively absorbed.Not as biologically active as organic forms of selenium, such asselenomethionine and selenium-rich yeast.The preferred form of selenium supplement is either selenomethionine orhigh selenium content yeast.Because of the way antioxidants function, they are best taken togetherwith other antioxidants, such as Zinc, Vitamin E etc...Selenium+Zinc Pharma Nord has documented high bioavailability &high degree of absorption. In one pharmacokinetic study using 77Se-labelled Precise yeast, absorption of selenium was 88,7% 15. What is so special about the SeleniumPharma Nord produce?Firstly, Pharma Nord make their own Selenium!Selenium from PN is an organic, selenium yeast. While this means thatits more expensive to produce, no other company produces an organic Seyeast to GMP standards in Europe, so to PN they have no choice but tomake their own.GMP status means that every single tablet contains precisely 100 g.Pharma Nords Selenium, SelenoPrecise is currently used in thePrevention of Cancer by Intervention with Selenium (PRECISE) study, apopulation study involving 40,000 test participants from Denmark, Swedenand England. 16. Who shouldnt take it?There are some who may not be suited to supplementing with thisparticular formulation. Included are:Those with yeast allergies or intolerances.Anyone with a Vitamin K deficiency and therefore prone to a higher risk ofbleeding with large doses of Vitamin E.Vitamin C supplements cannot be recommended to persons with any ironoverload syndrome (e.g. haemochromatosis).Vitamin C should not be used by persons suffering from renal insufficiencyor lack of glucose-6-phosphate dehydrogenaseDrugs:Aspirin: Studies indicate that concurrent administration of aspirin andvitamin C supplements can inhibit the uptake of the vitaminIron binding therapy: Preparations containing vitamin C may increase theeffect of deferoxamin therapy.Anticoagulation medicine: Vitamin E may increase the effect ofanticoagulant medicine 17. Any safety issues?Prolonged supplementation at doses in excess of 800 g/day can producesigns of Se toxicity including depression, nervousness, emotionalinstability, nausea and vomiting, garlic odour of the breath and sweat andin extreme cases, loss of hair & fingernails.The safety of a daily intake of 100 - 200 g selenium is well-establishedThere is also substantial evidence that Se is essential for proper fetalgrowth and development and requirements increase during pregnancy.Low Se levels have been linked with SIDS and like heart disease andcancer, SIDS has the highest occurence in areas of the world where Secontent of the soil and diet is lowest.