Lisinopril
1
Reactions 1461, p28 - 20 Jul 2013 S Lisinopril Angioedema of the small bowel in an elderly patient: case report A 69-year-old man developed angioedema of the small bowel while receiving lisinopril [Lisinopril Sandoz]. The man was admitted with an acute onset of abdominal pain, distension, nausea and diarrhoea. He had a history of hypertension, and had received β-adrenergic receptor antagonist treatment and the ACE inhibitor lisinopril for 10 days [dosage and route not stated]. Upon examination, he had diffuse abdominal tenderness on palpation without rebound or guarding. Tests showed an elevated CRP level, and an INR of 3.1. An abdominal x-ray showed slightly dilated small bowel loops with air-fluid levels. A CT scan of the abdomen revealed segmental small bowel wall thickening resulting in a stacked-coin appearance. There was a striking contrast between the low attenuation oedematous submucosa separating the outer muscular layers and serosa from the brightly-enhanced thickened mucosa. Lisinopril was withdrawn at admission. The man’s abdominal symptoms subsided within 2 days. He was discharged in good condition, and subsequently remained symptom-free. A repeat CT scan showed complete resolution of abnormalities. Author comment: "Visceral angioedema is a known rare adverse effect of angiotensin-converting enzyme inhibitors." Smet BS, et al. Angioedema of the small bowel caused by angiotensin converting enzyme inhibitor. JBR-BTR: Organe de la Societe Royale Belge de Radiologie (SRBR) 96: 41, No. 1, 2013. Available from: URL: http://www.rbrs.org/ template.php?sect=4&subs=4&id=70 - Belgium 803089865 1 Reactions 20 Jul 2013 No. 1461 0114-9954/13/1461-0001/$14.95 Adis © 2013 Springer International Publishing AG. All rights reserved
Transcript of Lisinopril
Reactions 1461, p28 - 20 Jul 2013
SLisinopril
Angioedema of the small bowel in an elderlypatient: case report
A 69-year-old man developed angioedema of the smallbowel while receiving lisinopril [Lisinopril Sandoz].
The man was admitted with an acute onset of abdominalpain, distension, nausea and diarrhoea. He had a history ofhypertension, and had received β-adrenergic receptorantagonist treatment and the ACE inhibitor lisinopril for10 days [dosage and route not stated]. Upon examination, hehad diffuse abdominal tenderness on palpation withoutrebound or guarding. Tests showed an elevated CRP level, andan INR of 3.1. An abdominal x-ray showed slightly dilatedsmall bowel loops with air-fluid levels. A CT scan of theabdomen revealed segmental small bowel wall thickeningresulting in a stacked-coin appearance. There was a strikingcontrast between the low attenuation oedematous submucosaseparating the outer muscular layers and serosa from thebrightly-enhanced thickened mucosa.
Lisinopril was withdrawn at admission. The man’sabdominal symptoms subsided within 2 days. He wasdischarged in good condition, and subsequently remainedsymptom-free. A repeat CT scan showed complete resolutionof abnormalities.
Author comment: "Visceral angioedema is a known rareadverse effect of angiotensin-converting enzyme inhibitors."Smet BS, et al. Angioedema of the small bowel caused by angiotensin convertingenzyme inhibitor. JBR-BTR: Organe de la Societe Royale Belge de Radiologie(SRBR) 96: 41, No. 1, 2013. Available from: URL: http://www.rbrs.org/template.php?sect=4&subs=4&id=70 - Belgium 803089865
1
Reactions 20 Jul 2013 No. 14610114-9954/13/1461-0001/$14.95 Adis © 2013 Springer International Publishing AG. All rights reserved
