Interferon-β-1a
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Reactions 1289 - 20 Feb 2010 Interferon-β-1a Chills, fatigue, pain and depressive mood: case report A woman was diagnosed with multiple sclerosis in July 1999, when she was approximately 21 years old; she started receiving IM interferon-β-1a [Avonex; dosage not stated] that August. However, she experienced severe adverse drug effects, such as chills, headaches, aches, fatigue and depressive mood [time to reaction onset not stated]. Her symptoms persisted despite treatment with anti-inflammatories and, in January 2000, IM interferon- β-1a was replaced with SC interferon-β-1a [Refib] 22µg [frequency not stated]. However, her symptoms recurred [time to reaction onset not stated], and the drug was withdrawn after 4 weeks. In August 2000, she began receiving SC interferon-β-1b and concomitant anti- inflammatories with good tolerance apart from initial head- and body aches. Anti-inflammatories were withdrawn that November. Oschmann P. Conversion to interferon beta-1b after intolerance of interferon beta-1a. [German]. Aktuelle Neurologie, Supplement 36 (Suppl. 3): S260-S261, 2009. Available from: URL: http://dx.doi.org/10.1055/s-0029-1220414 [German] - Germany 803006094 1 Reactions 20 Feb 2010 No. 1289 0114-9954/10/1289-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
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Transcript of Interferon-β-1a
Reactions 1289 - 20 Feb 2010
Interferon-β-1a
Chills, fatigue, pain and depressive mood: casereport
A woman was diagnosed with multiple sclerosis inJuly 1999, when she was approximately 21 years old; shestarted receiving IM interferon-β-1a [Avonex; dosage notstated] that August. However, she experienced severeadverse drug effects, such as chills, headaches, aches,fatigue and depressive mood [time to reaction onset notstated]. Her symptoms persisted despite treatment withanti-inflammatories and, in January 2000, IM interferon-β-1a was replaced with SC interferon-β-1a [Refib] 22µg[frequency not stated]. However, her symptoms recurred[time to reaction onset not stated], and the drug waswithdrawn after 4 weeks. In August 2000, she beganreceiving SC interferon-β-1b and concomitant anti-inflammatories with good tolerance apart from initial head-and body aches. Anti-inflammatories were withdrawn thatNovember.Oschmann P. Conversion to interferon beta-1b after intolerance of interferonbeta-1a. [German]. Aktuelle Neurologie, Supplement 36 (Suppl. 3): S260-S261,2009. Available from: URL: http://dx.doi.org/10.1055/s-0029-1220414 [German] -Germany 803006094
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Reactions 20 Feb 2010 No. 12890114-9954/10/1289-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
