Κεφάλαιο 2 - Monitoring του...

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  • 2 - Monitoring

    -

    . ( ),

    auto-PEEP, ,

    .

    Abstract

    The determination or evaluation of the mechanical properties of a patients respiratory system allows the in-

    tensive care physician to optimize the conditions of mechanical ventilation while protecting the patient from

    problems associated with the use of the ventilator. Airway pressure (maximum dynamic and static), auto-PEEP,

    elastance, compliance and resistance are all key measurable characteristics which must be constantly evaluated

    in each patient under mechanical ventilation.

    .

    2.1.

    . H

    (P),

    . , monitoring -

    ( ) : )

    (Pairway, Paw), ) (Pesophageal, Pes), -

    (Ppleural, Ppl), ) (V*) .

    2.2.

    H

    . (Palveolar,

    Palv) (Ppl), (Ptrans-pulmonary, Ptp), Ptp = Palv Ppl. (Ppl)

    (Patm), (Ptrans-thoracic Ptrans chest wall, Pcw),

    Pcw = Ppl Patm.

    Palv

    Patm (Ptrans-respiratory, Prs = Palv Patm), (Ptrans-airway, Pta) ,

    (Pairway opening, Pao) (Palv), -

    Pta = Pa Palv, ( 2.1) [1, 2].

  • T

    rs

    VPaw Rrs V Pex Irs V

    C

    2.1 : P , PALV

    , PPL , PATM , PAB , PTP , PCW -

    , PRS , PTA .

    , Paw ( , ,

    ) (Paw Patm) -

    : ) ,

    (resistive pressure cost), ) (elastic

    pressure cost), ) , PEEP auto-PEEP, ) .

    .

    :

    Paw , VT (tidal volume) , Crs (compliance of respiratory

    system) , Rrs (resistance of respiratory system)

    , (flow) , Pex (end expiratory pressure) , Irs

    (inertance f respiratory system) V (acceleration) -

    .

    , .

    , -

    , [3].

    2.3. (Paw)

    , , ,

    (Rrs) (Crs) . -

    ,

    . , ,

    ( 2.2).

  • , .

    . (

    1),

    .

    .

    ,

    .

    -

    . -

    .

    (Palv). PD

    , Ppeak. T PF PS -

    (pause). PZF

    . PS -

    . -

    .

    -

    .

    2.2

    .

    - ,

    . PD , PZF

    PS .

    Paw, ,

    ,

    (Crs) ( 2.3.).

  • 2.3

    . H -

    () , () -

    () .

    H Paw ( 2.3.)

    , , -

    . Paw

    ( 2.3.),

    . Paw , -

    PEEP auto-PEEP /

    , [4].

    , (triggers)

    .

    , .

    (triggered) , Paw .

    (scalloping) , ,

    () (VT).

    PD Paw

    -

    ( 2.4).

    2.4 (assist control) . -

    -

    .

    monitoring

    .

    , ,

    ,

    -

    [5].

  • 2.4. (peak dynamic pressure, Ppeak PD)

    , PD

    ( )

    (VT) ( 2.2). PD (Rrs), (Crs) -

    ,

    .

    PD.

    , cuff PD. H PD

    . H

    PD. PD ,

    ,

    .

    2.5. (S, Pplateau)

    H (PS)

    (Pex = PEEP + auto-PEEP) -

    . (CL),

    (Ccw) PS. H PS

    (stop-flow), 0,5-1,5 s.

    , Paw 0,3-2,0 s PS.

    , plateau, : stress

    relaxation (gas redistribution). H -

    (time-

    constant) . ,

    , Pplateau

    . H Pplateau -

    ( ). H Pplateau 1-5 cm H2O

    (PZF). ,

    , PS

    (Palv), . (stop-flow no flow conditions)

    Palv . H

    (Pex). H Pex

    PEEP auto-PEEP, PEEP (ZEEP)

    auto-PEEP.

    PS VT

    (Ccw) (CL)

    (FRC) auto-PEEP ( 2.5).

  • 2.5 H .

    H PS ,

    , PD. -

    (FRC) PS : ) -

    auto-PEP )

    (pressurevolume curve) .

    , -

    . , monitoring

    monitoring , , , -

    . , -

    , ,

    strain (strain = / )

    . ,

    PS (Pplateau). PS

    ,

    auto-PEEP. PS 30 cm H2O

    [6].

    2.6. (PZF)

    ,

    PD PZF. , Pplateau

    ( 2.1). H PD PZF (PD PZF)

    . H PZF PS (PZF PS)

    (pendelluft) /

    (viscoelastic phenomena).

    2.7. Auto-PEEP

    (TE)

    , (dynamic hyperinflation). , auto-

    P (Palv) Paw. aut-PEEP -

    (minute ventilation, VE) , ,

    . auto-P -

    , , -

    [7].

  • 2.6 . ().

    auto-P . , auto-P -

    , auto-P

    , (Ptrans-pulmonary).

    H -

    auto-P, -

    ( 2.7) [1, 5].

    2.7 3 auto-PEEP. H auto-PEEP

    (), . , ,

    , auto-PEEP

    ( ).

    H auto-P

    ,

    ( auto-P) ( 2.8). H auto-P,

    plateau, auto-

    P.

  • 2.8 () auto-PEEP (

    ): auto-PEEP 4 (9-5) cm H2O. () PEEP 5 9 cm H2O

    auto-PEEP.

    H auto-P , ,

    Paw ( ) ( 2.9). ,

    auto-P ( auto-P). -

    , , auto-P

    auto-P. -

    .

    2.9 (Paw) ,

    (CMV), . PD, P PS ,

    (Pplateau). (Palv)

    . -

    auto-PEEP (AP1). , auto-PEEP Paw

    (AP2).

  • T

    I

    T

    TPeepDCBAmPaw

    )(

    2.8. (mPaw) (mPA)

    2.8.1.

    , -

    (Presistive) ( 2.10, ) (Pelastic). H

    (Pelastic) : ) -

    (Pend expiratory, Pex = PEEP + auto-PEEP), -

    , FRC,

    ( 2.10, D). )

    ( 2.10, B). )

    (pause) ( 2.10, C). -

    , Paw , ,

    , . , Paw (mPaw) -

    Paw, , -

    (TT):

    Presistive = RI x VT RI VT ,

    Pelastic = VT/Crs Crs (compliance), C

    pause = PS x pause time D PEEP x TT.

    2.10

    . : (frictional). : -

    (tidal elastic). C: -

    (pause). D: PEEP. auto-PEEP

    .

    2.8.2.

    (mPA)

    ,

    (.., ).

  • ( )T

    T

    B C D E autoPeep TmP

    T

    , m mPaw 3 : 1. m

    . 2. m

    . 3. auto-PEEP mPA

    , mPaw . PA (mPA)

    PA

    (T):

    Pelastic = VT/Crs, C pause = PS x pause time, D PEEP x TT RE x VT, RE

    .

    mPA

    Paw (mPaw) :

    VE , R R .

    H mPA mPaw ,

    . , , mPA = mPaw RE =

    RI. , , .

    , -

    , mPA mPaw,

    (VE). , mPaw ,

    mPA [8].

    2.9. (Ppleural, Ppl) (Pesophageal, Pes)

    .

    Ppl

    . Ppl -

    . Ppl

    Ppl

    (deflation recoil) . , Ppl -

    ( ,

    Ptp = Palv Ppl).

    (pl). H

    (balloon)

    , .

    ,

    .

    , Pes

    . , , , Pes Ppl. ,

    Pes Ppl.

    H .

    ,

    (sniff maneuver). O

    . , 10 cm , ,

    . ,

    , . 8 ml

    ( )60

    EE I

    VmP mPaw R R

  • , , 6,5-7,5 ml, 0,5-1,5 ml.

    (Pes)

    (Paw) .

    , (transpulmonary)

    (Paw Pes) [9, 10].

    2.10.

    -

    , 25 %

    . -

    ,

    . 0 cm H2O

    6-11 cm H2O .

    ,

    .

    2.11. (flow, )

    H ( ) . H

    , R = P/ .

    = x Ve, . (laminar), e 1,

    (turbulent), 2 , , .

    VT, Crs ,

    Paw. , Crs ,

    .

    . ,

    , ( 2.6). ( ) -

    (stop flow technique) . -

    , ,

    (expiratory flow limitation).