PRP Art & science

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PRP art &science

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  • Platelet Rich Plasma Art & science Islam Kassem,BDS,MSc,FDS RCS Consultant oral & maxillofacial Surgeon ikassem@dr.com
  • Angle Face Left New technology of injection your own blood to get a Youthful Look . . ikassem@dr.com
  • Why Are Celebrities Injecting Their Faces With Blood? ikassem@dr.com
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  • Platelet? Anuclear piece of cytoplasm Include hemostasis, -granule,lysosomal granule, dense granules ikassem@dr.com
  • At least 7 different growth factors that stimulate bone & soft tissue healing PDGF aa,bb,ab TGF b1,b2 VEGF EGF ikassem@dr.com
  • Days of operation ikassem@dr.com
  • 7 days later PLT exhausted after 7 days Macrophage by low oxygen tension, acidity, lactate concentration Secrete same growth factors Activated until it is down regulated by the restoration of normal oxygen tension ikassem@dr.com
  • Day 3rd ikassem@dr.com
  • 17days Graft is completely permeated by new capillaries Initial osteoid formation Osteoclast resorb osteoid and BMP released New bone formation and maturation ikassem@dr.com
  • Days 14 ikassem@dr.com
  • The mechanism of growth factor effects on cells Inactive state ikassem@dr.com
  • Activation activation ikassem@dr.com
  • Clinical effects of PRP on bone regeneration Platelet RBC Normal blood PRP ikassem@dr.com
  • Trabecular areaNative mandible Autogenous BG ikassem@dr.com
  • Clinical effects of PRP on soft tissue healing Split thickness skin graft donor site healing ikassem@dr.com
  • 6 days Thrombin side : 5% epithelization 95% granulation tissue PRP side ; 95% epithelization 5% granulation tissue ikassem@dr.com
  • 6 months Thrombin side : scarring hypo and hyper- pigmentation area PRP side ;less scarring Much less pigmentation change ikassem@dr.com
  • Patient discomfort Patient discomfort decrease ikassem@dr.com
  • Epithelization ikassem@dr.com
  • 6days ikassem@dr.com
  • 1 months ikassem@dr.com
  • Contraindications Pre-existing coagulation defect : thrombocytopenia, hypofibrinogenia Hypersensitivity to bovine thrombin ikassem@dr.com
  • Clinical steps ikassem@dr.com
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  • Clinical application ikassem@dr.com
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  • Ridge preservation ikassem@dr.com
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