Norm

al1

N

orm

al1

0

Norm

al1

1

Norm

al1

2

Norm

al1

3

Norm

al1

5

Norm

al1

6

Norm

al1

7

Norm

al1

8

Norm

al1

9

Norm

al2

N

orm

al2

0

Norm

al2

1

Norm

al2

2

Norm

al2

3

Norm

al2

4

Norm

al2

5

Norm

al2

6

Norm

al2

7

Norm

al2

8

Norm

al2

9

Norm

al3

N

orm

al3

0

Norm

al3

1

Norm

al3

2

Norm

al3

3

Norm

al3

4

Norm

al3

5

Norm

al3

6

Norm

al4

N

orm

al5

N

orm

al6

N

orm

al7

N

orm

al8

N

orm

al9

1

02a

116a

19

a

30

a

47

a

48

a

57

a

65

a

82

a

91

a

92

a

94

a

97

a

9a

104a

108a

111a

115a

117a

43

a

46

a

49

a

53

a

75

a

36_O

A

66_O

A

26_O

A

15_O

A

384_O

A

291_O

A

320_O

A

220_O

A

221_O

A

7_O

A

214_O

A

8_O

A

001-3

2A

0

03-3

3A

0

05-3

1A

0

04-3

1A

0

06-3

1A

0

03-2

9A

0

02-2

9A

0

04-2

9A

0

02-2

8A

0

07-3

1A

0

01-3

1A

0

03-3

2A

0

04-3

2A

0

02-3

1A

0

01-3

4A

0

03-3

4A

0

09-3

1A

0

02-3

4A

0

03-1

2A

0

06-2

0A

0

05-3

3A

0

04-2

0A

0

04-2

1A

8

0_R

A

40_R

A

24_R

A

13_R

A

44_R

A

17_R

A

38_R

A

99_R

A

14_R

A

48_R

A

12_R

A

37_R

A

6_R

A

18_R

A

MIG IP-10 IFN-α2 IL-7 IL-12(p70) IL-10 IL-13 β-NGF IL-18 IL-2Rα SCF IL-3 IL-12p40 M-CSF HGF SCGF-β MCP-1 IL-8 IL-1ra VEGF IL-6 IL-16 IL-1α TNF-β LIF SDF-1α TNF-α IL-9 IFN-γ IL-5 IL-4 MCP-3 IL-1β G-CSF GM-CSF IL-2 IL-15 IL-17 FGF basic CTACK GROα MIP-1β MIP-1α

Normal sera OA sera OA SF RA sera RA SF 0.5 x normal

0.125 x normal

0.25 x normal

Normal mean 2 x normal 4 x normal

8 x normal

Figure 1, Sohn et al.