Interferon-β-1a
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Reactions 1380 - 3 Dec 2011 S Interferon-β-1a Thrombotic microangiopathy: case report A 45-year-old man was diagnosed with relapsing- remitting multiple sclerosis in 2004. He started receiving SC interferon-β-1a 44µg three times per week, in March 2005. In March 2006, proteinuria was first noticed at a flow of 0.2 g/24 hours. Two years later, proteinuria increased to 1.72 g/24 hours composed of 80% albumin. In January 2010, renal biopsy revealed thrombotic microangiopathy. He received treatment with an ACE inhibitor; however, proteinuria increased to 4 g/24 hours in December 2010. Relapse again occurred in March 2011, and interferon-β-1a was switched to glatiramer acetate. At two-month follow-up, proteinuria was decreasing. Author comment: "The temporal association between proteinuria, interferon therapy’s institution and its arrest, is striking and suggestive of a causal link." Bensa C, et al. A case of thrombotic microangiopathy associated with subcutaneous beta-1a-interferon therapy. 27th Congress of the European Committee for Treatment and Research in Multiple Sclerosis : abstr. P 526, 19 Oct 2011. Available from: URL: http://link.adisinsight.com/r6H8C - France 803063664 1 Reactions 3 Dec 2011 No. 1380 0114-9954/10/1380-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
Transcript of Interferon-β-1a
Reactions 1380 - 3 Dec 2011
SInterferon-β-1a
Thrombotic microangiopathy: case reportA 45-year-old man was diagnosed with relapsing-
remitting multiple sclerosis in 2004. He started receivingSC interferon-β-1a 44µg three times per week, inMarch 2005. In March 2006, proteinuria was first noticedat a flow of 0.2 g/24 hours. Two years later, proteinuriaincreased to 1.72 g/24 hours composed of 80% albumin. InJanuary 2010, renal biopsy revealed thromboticmicroangiopathy. He received treatment with an ACEinhibitor; however, proteinuria increased to 4 g/24 hours inDecember 2010. Relapse again occurred in March 2011,and interferon-β-1a was switched to glatiramer acetate. Attwo-month follow-up, proteinuria was decreasing.
Author comment: "The temporal association betweenproteinuria, interferon therapy’s institution and its arrest, isstriking and suggestive of a causal link."Bensa C, et al. A case of thrombotic microangiopathy associated withsubcutaneous beta-1a-interferon therapy. 27th Congress of the EuropeanCommittee for Treatment and Research in Multiple Sclerosis : abstr. P 526, 19 Oct2011. Available from: URL: http://link.adisinsight.com/r6H8C -France 803063664
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Reactions 3 Dec 2011 No. 13800114-9954/10/1380-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
