Comparison of the two most common causes of carbapenem resistance in Enterobacteriaceae: Klebsiella pneumoniae carbapenemase (KPC) and New Delhi Metallo-β-Lactamase (NDM) type β-lactamases

KPC NDMβ-lactamase type Serine Metallo-β-lactamaseAmbler cass A BMost commonly affected species

K. pneumoniae K. pneumoniae

Other species commonly affected

E. coli, E. cloacae E. coli, E. cloacae

Common MLST types ST258 VariableGeographic epicenter NE USA India, Pakistan

β-lactam antibiotics affectedPenicillins, cephalosporins, carbapenems

Penicillins, cephalosporins, carbapenems

Phenotypic detectionModified Hodge Test (MHT) positive

Unknown (positive MHT likely)

Inhibitors Boronic acid EDTAEDTA: ethylene diaminete traacetic acid.Reproduced from: Sidjabat H, Nimmo GR, Walsh TR, et al. Carbapenem Resistance in Klebsiella pneumoniae Due to the New Delhi Metallo-β-lactamase. Clin Infect Dis 2011; 52:481, by permission of Oxford University Press. Copyright © 2011.

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