1. Dr. Vijay Marakala, MBBS, MD. Assistant professor BIOCHEMISTRY SIMS & RC

2. Chemistry Sources RDA Metabolism Functions Deficiency Toxicity

3. Tocopherols -tocopherol -tocopherol -tocopherol -tocopherol Tocotrienols -tocotrienols -tocotrienols -tocotrienols -tocotrienols

4. RDA 8 10 mg/day The daily requirement increases with increase in dietary intake of PUFA

5. Absorption Upper SI Along with lipids Transport Chylomicron VLDL and LDL Storage Adipose tissue liver

6. As a biological antioxidant Prevents lipid peroxidation of biological membrane Prevents peroxidation of vitamin A & PUFA Reproductive functions & prevents sterility Vitamin E

7. Selenium complements the antioxidant effects of vitamin E and reduces the requirement of vitamin E

8. Causes Inadequate intake Impaired absorption Features Hemolytic anaemia in the new born Muscle weakness Spinocerebellar ataxia and impaired vision

9. Pylloquinone Present in plants Vitamin K1 Menaquinone Produced by intestinal bacteria Vitamin K2 Menadione Synthetic form Vitamin K3

10. 80g/day

11. Absorption Upper SI Along with lipids Transport Chylomicron LDL Storage Liver

12. Role in blood coagulation Cofactor for gamma carboxylation of glutamic acid in clotting factors II, VIII, IX and X Role in bone mineralization Cofactor for gamma carboxylation of glutamic acid in osteocalcin

13. Causes In newborn Impaired absorption Sterile bacterial flora Features Bleeding Prolonged prothrombin time

14. Dicumarol Warfarin