Vitamin E & K Lecture 3 BIOCHEMISTRY

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  • 1. Dr. Vijay Marakala, MBBS, MD. Assistant professor BIOCHEMISTRY SIMS & RC
  • 2. Chemistry Sources RDA Metabolism Functions Deficiency Toxicity
  • 3. Tocopherols -tocopherol -tocopherol -tocopherol -tocopherol Tocotrienols -tocotrienols -tocotrienols -tocotrienols -tocotrienols
  • 4. RDA 8 10 mg/day The daily requirement increases with increase in dietary intake of PUFA
  • 5. Absorption Upper SI Along with lipids Transport Chylomicron VLDL and LDL Storage Adipose tissue liver
  • 6. As a biological antioxidant Prevents lipid peroxidation of biological membrane Prevents peroxidation of vitamin A & PUFA Reproductive functions & prevents sterility Vitamin E
  • 7. Selenium complements the antioxidant effects of vitamin E and reduces the requirement of vitamin E
  • 8. Causes Inadequate intake Impaired absorption Features Hemolytic anaemia in the new born Muscle weakness Spinocerebellar ataxia and impaired vision
  • 9. Pylloquinone Present in plants Vitamin K1 Menaquinone Produced by intestinal bacteria Vitamin K2 Menadione Synthetic form Vitamin K3
  • 10. 80g/day
  • 11. Absorption Upper SI Along with lipids Transport Chylomicron LDL Storage Liver
  • 12. Role in blood coagulation Cofactor for gamma carboxylation of glutamic acid in clotting factors II, VIII, IX and X Role in bone mineralization Cofactor for gamma carboxylation of glutamic acid in osteocalcin
  • 13. Causes In newborn Impaired absorption Sterile bacterial flora Features Bleeding Prolonged prothrombin time
  • 14. Dicumarol Warfarin