Betabis (Bisoprolol).ppt

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  • 1. Welcome to the Session of Betabis (Bisoprolol hemifumarate USP) Highly selective beta blocker Presented by Mohammed Moshiur Rahaman

2. Product Information Brand Name : BETABIS 2.5 & 5 (Beta from Beta blocker and Bis from Bisoprolol) Composition : Bisoprolol hemifumarate USP 2.5 mg & 5 mg Therapeutic group : Antihypertensive (1-blocker) Pack Size : 3 X 10 tablets for both strength Unit Price (proposed) : 06.00 tk (2.5 mg tablet) 10.00 tk (5 mg tablet) 3. Total Market of BISOPROLOL 20 core with 105% positive growth 4. Brands Yearly value sale Growth BISLOL OPI 95,972,044 87.64 BISLOL 2.50 53,707,538 74.91 BISLOL 5 39,384,996 92.66 BISLOL 10 2,879,510 999.00 CONCOR MCK 41,289,193 99.18 CONCOR 2.50 20,844,909 50.55 CONCOR 5 20,308,556 195.03 CONCOR 10 135,728 999.00 ANCOR ATP 28,196,448 119.39 ANCOR 2.50 15,724,136 100.21 ANCOR 5 MG 12,472,311 149.53 BISOCOR SQA 21,590,349 119.58 BISOCOR 2.50 11,446,372 103.01 BISOCOR 5 9,944,507 138.47 BISOCOR 10 199,470 724.43 TENOBIS D-I 8,985,688 94.59 TENOBIS 2.50 4,806,887 95.46 5. Questions 1. What is happening when 1 receptor is activated? 2. What is happening when 2 receptor is activated? 6. Answers 1. Activation of the 1 receptor leads to increases incontraction force and heart rate (In Heart). 2. Activation of the 2 receptor leads to smooth muscle relaxation (In Lung). 7. Non-selective VS Selective 8. Non selective Selective Causes bronchoconstriction So not safe for asthma patients Does not cause bronchoconstriction So safe for asthma patients Decreases insulin secretion & impairs insulin sensitivity. Thus Increases blood sugar level, even may causes new onset of diabetes Not safe for Diabetes patients Does not decrease insulin secretion & impair insulin sensitivity Does not increase blood sugar level ,does not cause new onset of diabetes Safe for Diabetes patients Has unfavorable effect on Blood lipid profile Has no effect on blood lipid profile 9. Generatio n Selectivity Generic 1st Non selective beta blocker (blocks both 1 & 2) Propanolol 2nd Selective beta blocker (blocks only 1 ) cardioselective Atenolol ( Tenoloc), Metoprolol, Bisoprolol 3rd Beta blocker + Vasodilatory activity 1. Non selective beta blocker (blocks both 1 & 2) and blocker activity (Vasodilation) 2. Selective beta blocker (blocks only 1) and blocker activity (Vasodilation) 1. Carvedilol (Carvipress) 2. Nevibolol 10. Indications Indicated in the management of Hypertension Angina. It may be used alone or in combination with other antihypertensive agents 11. Mechanism of Action Bisoprolol is the most potent 1-selective -blocker. It has the highest level of 1-selectivity and by blocking the hearts 1 adrenergic receptors it reduces heart rate & force of contraction of the heart, thus lowers blood pressure. 12. Dosage And Administration 13. The dose of Betabis must be individualized to the needs of the patient. The usual starting dose is Betabis 5 mg once daily. In some patients, Betabis 2.5 mg may be an appropriate starting dose. If the antihypertensive effect of Betabis 5 mg is inadequate, the dose may be increased to Betabis 10 mg and then, if necessary, to 20 mg once daily. Patients with renal or Hepatic Impairment : In patients with hepatic impairment (hepatitis or cirrhossis) or renal dysfunction (creatinine clearance