Post on 22-Aug-2014
description
Platelet Rich Plasma
Art & science
Islam Kassem,BDS,MSc,FDS RCS
Consultant oral & maxillofacial Surgeon
ikassem@dr.com
Angle Face Left New technology of injection
your own blood to get a
Youthful Look .
.
ikassem@dr.com
Why Are Celebrities Injecting Their Faces With Blood?
ikassem@dr.com
ikassem@dr.com
Platelet?
Anuclear piece of cytoplasm
Include hemostasis,
α-granule,lysosomal granule, dense granules
ikassem@dr.com
At least 7 different growth factors that stimulate bone & soft tissue healing
PDGF aa,bb,ab
TGF b1,b2
VEGF
EGF
ikassem@dr.com
Days of operation
ikassem@dr.com
7 days later
PLT exhausted after 7 days
Macrophage by low oxygen tension, acidity, lactate concentration
Secrete same growth factors
Activated until it is down regulated by the restoration of normal oxygen tension
ikassem@dr.com
Day 3rd
ikassem@dr.com
17days
Graft is completely permeated by new capillaries
Initial osteoid formation
Osteoclast resorb osteoid and BMP released
New bone formation and maturation
ikassem@dr.com
Days 14
ikassem@dr.com
The mechanism of growth factor effects on cells
Inactive state
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Activation
activation
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Clinical effects of PRP on bone regeneration
Platelet
RBC
Normal blood PRP
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Trabecular area Native mandible Autogenous BG
ikassem@dr.com
Clinical effects of PRP on soft tissue healing
Split thickness skin graft donor site healing
ikassem@dr.com
6 days
Thrombin side : 5% epithelization 95% granulation tissue PRP side ; 95% epithelization 5% granulation tissue
ikassem@dr.com
6 months Thrombin side : scarring hypo and hyper-pigmentation area PRP side ;less scarring Much less pigmentation change
ikassem@dr.com
Patient discomfort
Patient discomfort decrease
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Epithelization
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6days
↔
↔
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1 months
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Contraindications
Pre-existing coagulation defect
: thrombocytopenia, hypofibrinogenia…
Hypersensitivity to bovine thrombin
ikassem@dr.com
Clinical steps
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Clinical application
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Ridge preservation
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