6

01Increases

collagen synthesis

02Enhance

DEJ

Use 1 ingredient Get 3 effects

03Increases

Adipogenesis

Hybridpeptide BIO

Catalog Number ICP1003

DescriptionHybrid peptide BIO effectively reduces fine wrinkle through stimulation of the collagen production in the fibroblast cells, collagen-XVII/laminin-5/integrin α6 production in the keratinocyte, adipogenesis in the pre-adipocyte, and myogenesis in the myocytes.

Aged skin

Hybrid peptide BIO

•�Smoothing of Epidermal/Dermal junction•�Disorganisation and loss

of collagen fibres•�Reduction of adipocyte

and lipid droplet

•�Enhances dermal- epidermal junction•�Increases Adipogenesis•�Increases collagen

synthesis

Young skin

* DEJ : Dermal-epidermal junction

DEJ

collagenLipid droplet

EpidermisEpidermis

DermisDermis

HYPODERMIS

HYPODERMIS

7

Ingredients for Cosmetic and Pharmaceutical Applications

Step2 : Cell-to-cell communication

Step3 : Adipogenesis Final effect : Wrinkle reduction

PCPC/INCI Name

• Biotin, Hexapeptide-2

Composition

• 0.2% Hybrid Peptide BIO / 2.0% 1,2-Hexanediol / 97.8% Water

Recommended Dosage

• 1~5% for cream and essence

Application

• anti-wrinkle • anti-ageing

Patent No KP 10-1667383, US 9,180,082, EP 2666780, JP 6014240

Use of Hybrid Peptide BIO contained product can reduce fine wrinkle Hybrid Peptide BIO enhances formation of lipid droplet in activated pre-adipocyte cells

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collagen-X Ⅶ

Laminin-5

Integrin

ß-actin

Hybrid peptide BIO

Laminin-5

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CollagenⅩⅦ

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Integrin-α6

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Hybrid Peptide BIO increases expression of collagen XVII, laminin-5, and integrin α-6 in keratinocyte cells

Biological and Clinical Activity

Step1 : Collagen type-1

Masson’s trichome staining

Hybrid Peptide BIO increases expression of collagen type1 in 3D artificial skin. Hybrid Peptide BIO prevents keratinocyte-mediated reduction of collagen synthesis

% o

f med

ia o

nly

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media blank Hybrid peptide BIO 25uM

Hybrid peptide BIO 100uM

■serum starvation■no serum starvation

Hybrid peptide BIO

Hybrid peptide BIOHybrid peptide BIO

Blank BeforeHybrid peptide BIO 5 weeks

Control Hybrid peptide BIO