Hybrid Catalog Number peptide BIO 01 -...
2
6 01 Increases collagen synthesis 02 Enhance DEJ Use 1 ingredient Get 3 effects 03 Increases Adipogenesis Hybrid peptide BIO Catalog Number ICP1003 Description Hybrid peptide BIO effectively reduces fine wrinkle through stimulation of the collagen production in the fibroblast cells, collagen-XVII/laminin-5/integrin α6 production in the keratinocyte, adipogenesis in the pre-adipocyte, and myogenesis in the myocytes. Aged skin Hybrid peptide BIO • Smoothing of Epidermal/ Dermal junction • Disorganisation and loss of collagen fibres • Reduction of adipocyte and lipid droplet • Enhances dermal- epidermal junction • Increases Adipogenesis • Increases collagen synthesis Young skin *DEJ : Dermal-epidermal junction DEJ collagen Lipid droplet Epidermis Epidermis Dermis Dermis HYPODERMIS HYPODERMIS
Transcript of Hybrid Catalog Number peptide BIO 01 -...
6
01Increases
collagen synthesis
02Enhance
DEJ
Use 1 ingredient Get 3 effects
03Increases
Adipogenesis
Hybridpeptide BIO
Catalog Number ICP1003
DescriptionHybrid peptide BIO effectively reduces fine wrinkle through stimulation of the collagen production in the fibroblast cells, collagen-XVII/laminin-5/integrin α6 production in the keratinocyte, adipogenesis in the pre-adipocyte, and myogenesis in the myocytes.
Aged skin
Hybrid peptide BIO
•�Smoothing of Epidermal/Dermal junction•�Disorganisation and loss
of collagen fibres•�Reduction of adipocyte
and lipid droplet
•�Enhances dermal- epidermal junction•�Increases Adipogenesis•�Increases collagen
synthesis
Young skin
* DEJ : Dermal-epidermal junction
DEJ
collagenLipid droplet
EpidermisEpidermis
DermisDermis
HYPODERMIS
HYPODERMIS
7
Ingredients for Cosmetic and Pharmaceutical Applications
Step2 : Cell-to-cell communication
Step3 : Adipogenesis Final effect : Wrinkle reduction
PCPC/INCI Name
• Biotin, Hexapeptide-2
Composition
• 0.2% Hybrid Peptide BIO / 2.0% 1,2-Hexanediol / 97.8% Water
Recommended Dosage
• 1~5% for cream and essence
Application
• anti-wrinkle • anti-ageing
Patent No KP 10-1667383, US 9,180,082, EP 2666780, JP 6014240
Use of Hybrid Peptide BIO contained product can reduce fine wrinkle Hybrid Peptide BIO enhances formation of lipid droplet in activated pre-adipocyte cells
Blank
collagen-X Ⅶ
Laminin-5
Integrin
ß-actin
Hybrid peptide BIO
Laminin-5
Blank
CollagenⅩⅦ
Blank
Integrin-α6
Blank
Hybrid Peptide BIO increases expression of collagen XVII, laminin-5, and integrin α-6 in keratinocyte cells
Biological and Clinical Activity
Step1 : Collagen type-1
Masson’s trichome staining
Hybrid Peptide BIO increases expression of collagen type1 in 3D artificial skin. Hybrid Peptide BIO prevents keratinocyte-mediated reduction of collagen synthesis
% o
f med
ia o
nly
0%
20%
40%
60%
80%
100%
140%
120%
180%
160%
media blank Hybrid peptide BIO 25uM
Hybrid peptide BIO 100uM
■serum starvation■no serum starvation
Hybrid peptide BIO
Hybrid peptide BIOHybrid peptide BIO
Blank BeforeHybrid peptide BIO 5 weeks
Control Hybrid peptide BIO
