Post on 09-Aug-2019
DCR3
DCR1/DCR2
FasL
FAS
TNFR2
TNF
TNFR1
TNF
Apo3L TRAIL
FADD
CD4CXCR4/CCR5
DR3/DR4
HIV1
TRADD RIPRAIDD TRAF2
TRAF1
Caspase2
Caspase8 FLIP
IKK
FADD
DR5
Perforin
NIK MEKK
Nef
DaxxDEDAF
Perfo
rinPe
rforin
Perfo
rin
Perfo
rinGr
anzy
me-B
Granzyme-B
Granzyme-BERK
PKC
Caspase7
PLC-y Caspase10
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GrowthFactors
GFR
ASK1
ASK1
PIP2PI3K
Cathepsins
DAGMKK7
Caspase1(ICE)
Survivin
PP2A
Ceramide
TAK1
MKK4
AIP1
PDK-1
P90RSK
Raf1
Akt mTOR
MDM2
BAX
ETS2
JNK
IP3R
IP3
CellSurvival
BAD
P53
CytoC
BCL2BCL-XL P53AIP1 PUMA
tBID
APAF1
Smac/DIABLO
HtrA2/Omi
BCL2
Beclin1 BAX
CytoC
Caspase9
IAP
Withdrawl ofGrowth Factors
Cytokines
BIMHSP27
HSP70
HSP90
Ca2+
Ca2+
Ca2+
Caspase12
Stress
Caspase3
CalmCell Shrinkage
Membraneblebbing
CellDeath
JNKPathway
ROCK
2
IRE1α
DAPK1
TRAF2ASK1
JNKIP3R
Ca2+
MDM2
PARPDNA-PK
CAD(DFF40)
ICAD(DFF45)
Acinus
Lamin B1
Aif
EndoG
DNADamaged
ATM/ATR
HDAC
P53
P21
NF-кB
P53
NF-кB
Sirt1
ChomationCondensation
DNA Fragmentation
Apoptosis
P14ARF
CAD(DFF40)
P21Caspase3
Caspase6
EndoG
Aif
BAD14-3-3
PIP3
BID
NOXA
Cellular Apoptosis Pathway
antibody and ELISA experts
Cellular Apoptosis Pathwayw w w . b o s t e r b i o . c o m
Activation
Indirect Activation
Binding
Expression
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Enzyme Catalysis
Inhibition
Leads to
Modification
Membership
Proteolysis
Reaction (Uni)
Reaction (Bi)
Related Pathway
Translocation