Cellular Apoptosis Pathway - bosterbio.com · Pathway ROCK2 IRE1α DAPK1 TRAF2 ASK1 JNK IP3R Ca 2+...
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DCR3 DCR1/ DCR2 FasL FAS TNFR2 TNF TNFR1 TNF Apo3L TRAIL FADD CD4 CXCR4/CCR5 DR3/ DR4 HIV1 TRADD RIP RAIDD TRAF2 TRAF1 Caspase2 Caspase8 FLIP IKK FADD DR5 Perforin NIK MEKK Nef Daxx DEDAF Perforin Perforin Perforin Perforin Granzyme-B Granzyme-B Granzyme-B ERK PKC Caspase7 PLC-y Caspase10 ---------------------- ----------- ------------------- Growth Factors GFR ASK1 ASK1 PIP2 PI3K Cathepsins DAG MKK7 Caspase1 (ICE) Survivin PP2A Ceramide TAK1 MKK4 AIP1 PDK-1 P90RSK Raf1 Akt mTOR MDM2 BAX ETS2 JNK IP3R IP3 Cell Survival BAD P53 CytoC BCL2 BCL-XL P53AIP1 PUMA tBID APAF1 Smac/ DIABLO HtrA2/Omi BCL2 Beclin1 BAX CytoC Caspase9 IAP Withdrawl of Growth Factors Cytokines BIM HSP27 HSP70 HSP90 Ca 2+ Ca 2+ Ca 2+ Caspase12 Stress Caspase3 Calm Cell Shrinkage Membrane blebbing Cell Death JNK Pathway ROCK2 IRE1α DAPK1 TRAF2 ASK1 JNK IP3R Ca 2+ MDM2 PARP DNA-PK CAD (DFF40) ICAD (DFF45) Acinus Lamin B1 Aif EndoG DNA Damaged ATM/ATR HDAC P53 P21 NF-кB P53 NF-кB Sirt1 Chomation Condensation DNA Fragmentation Apoptosis P14ARF CAD (DFF40) P21 Caspase3 Caspase6 EndoG Aif BAD 14-3-3 PIP3 BID NOXA Cellular Apoptosis Pathway antibody and ELISA experts Cellular Apoptosis Pathway www.bosterbio.com Activation Indirect Activation Binding Expression ------------- Enzyme Catalysis Inhibition Leads to Modification Membership Proteolysis Reaction (Uni) Reaction (Bi) Related Pathway Translocation
Transcript of Cellular Apoptosis Pathway - bosterbio.com · Pathway ROCK2 IRE1α DAPK1 TRAF2 ASK1 JNK IP3R Ca 2+...
DCR3
DCR1/DCR2
FasL
FAS
TNFR2
TNF
TNFR1
TNF
Apo3L TRAIL
FADD
CD4CXCR4/CCR5
DR3/DR4
HIV1
TRADD RIPRAIDD TRAF2
TRAF1
Caspase2
Caspase8 FLIP
IKK
FADD
DR5
Perforin
NIK MEKK
Nef
DaxxDEDAF
Perfo
rinPe
rforin
Perfo
rin
Perfo
rinGr
anzy
me-B
Granzyme-B
Granzyme-BERK
PKC
Caspase7
PLC-y Caspase10
----------------------
-----------
-------------------
GrowthFactors
GFR
ASK1
ASK1
PIP2PI3K
Cathepsins
DAGMKK7
Caspase1(ICE)
Survivin
PP2A
Ceramide
TAK1
MKK4
AIP1
PDK-1
P90RSK
Raf1
Akt mTOR
MDM2
BAX
ETS2
JNK
IP3R
IP3
CellSurvival
BAD
P53
CytoC
BCL2BCL-XL P53AIP1 PUMA
tBID
APAF1
Smac/DIABLO
HtrA2/Omi
BCL2
Beclin1 BAX
CytoC
Caspase9
IAP
Withdrawl ofGrowth Factors
Cytokines
BIMHSP27
HSP70
HSP90
Ca2+
Ca2+
Ca2+
Caspase12
Stress
Caspase3
CalmCell Shrinkage
Membraneblebbing
CellDeath
JNKPathway
ROCK
2
IRE1α
DAPK1
TRAF2ASK1
JNKIP3R
Ca2+
MDM2
PARPDNA-PK
CAD(DFF40)
ICAD(DFF45)
Acinus
Lamin B1
Aif
EndoG
DNADamaged
ATM/ATR
HDAC
P53
P21
NF-кB
P53
NF-кB
Sirt1
ChomationCondensation
DNA Fragmentation
Apoptosis
P14ARF
CAD(DFF40)
P21Caspase3
Caspase6
EndoG
Aif
BAD14-3-3
PIP3
BID
NOXA
Cellular Apoptosis Pathway
antibody and ELISA experts
Cellular Apoptosis Pathwayw w w . b o s t e r b i o . c o m
Activation
Indirect Activation
Binding
Expression
-------------
Enzyme Catalysis
Inhibition
Leads to
Modification
Membership
Proteolysis
Reaction (Uni)
Reaction (Bi)
Related Pathway
Translocation
