Sup Fig 1

A

C

CF

PY

FP

CF

PY

FP

ble

ach

B

pI

70-

50-

40-

5.2 5.6 6.0 7.5 7.9

60-

MM9 16

23

20

1719

2115

13

147

5

6

2

1

310

4

811

22

12

18

9 16

23

20

17 19

21

15

13

147

5

6

2

1

310

4

811

22

12

18

Sup Fig 2

Sup Fig 3

A

1 1 1 0.80 0.43 0.48

βActin

R1 R2 R3R1 R2 R3

PDIA1

siCrtl

siPDIA1

+ + +

+ + +- - -

- - -

A549

46

57

R.D.

kDa

1 1 1 0.20 0.48 0.70

βActin

R1 R2 R3R1 R2 R3

PDIA3

siCrtl

siPDIA3

+ + +

+ + +- - -

- - -

A549

46

58

R.D.

kDa

1 1 1 0.10 0.05 0.20

βActin

R1 R2 R3R1 R2 R3

PDIA4

siCrtl

siPDIA4

+ + +

+ + +- - -

- - -

A549

48

72

R.D.

kDa

46

PDIA6

1 1 1 0.45 0.11 0.16

βActin

R1 R2 R3R1 R2 R3

PDIA4

siCrtl

siPDIA6

+ + +

+ + +- - -

- - -

A549

48

72

R.D.

kDa

46

PDIA6

B

C D

Supp Fig 4

NT

25µ

M C

DD

P

siPDIA4 siPDIA6

R1

5.5 6

31 22

siCrtl

3

7Ce

ll c

ou

nt

TMRM (m)

A

Ce

ll c

ou

nt

3 5 6

8 36 24

siPDIA4 siPDIA6

SubG1

R1

siCrtl

Ce

ll c

ou

nt

B

NT

25µ

M C

DD

P

C100

95

90

85

80

75

70

0

Cel

l su

rviv

al (

%)

/

25µM CDDP

Cas

pas

e 3-

7 ac

tivi

ty (

RF

U)

25µM CDDP

C D

h h

6345

13

21

58

8.5

A2780R

9.1 67.3

20.8

1.6 8.27

89

8.9 33.90

56.4

2.9 6.2

90

1.8 5.15

91.2

9.0 7.8

82.3

An

ne

xin

-PE

(+)

7AAD(+)

8.3

5325

TMRM (m)

A2780R

Ce

ll c

ou

nt

13 23

28

SubG1

A2780R

Ce

ll c

ou

nt

Sup Fig 5

A

B D

C

siPDIA4 siPDIA6siCrtl

NT

25µ

M C

DD

P

siPDIA4 siPDIA6siCrtl

NT

25µ

M C

DD

P

siCrtl siPDIA4 siPDIA6

NT

25µ

M C

DD

P

A2780R

βActin

PDIA4

siCrtl

siPDIA4

+ -

- +

46

72

kDa

βActin

PDIA6

siCrtl

siPDIA6

+ -

- +

46

48

kDa

Crtl PDIA4NT Crtl. PDIA6 PDIA4 PDIA6

25Oxaliplatinum (µM) 50 25 50 25 50 - - - -

-Carboplatinum (µM) - - - - - 25 50 25 50

80

100

120

60

40

20

0Crtl.

Cell

viab

ility

(%)

-

25

-

50

R3R2R1

- -

- -

Sup Fig 6