AcLDL

AcLDL

oxLDL

Endosome

?

αvβ3

LOX-1SR-AI

CD68

SR-AII

C

C

C

C

C

C

C

C

CN

N

N

oxLDL

LDL HDL

SR-BI

CN

N

Non-inflammatory clearance Inhibition of TLR signaling

N

N

N

NC

C

C

C

C

C

C

C

MARCO

SRCL

SREC-I

SREC-II

Class B: CD36 + SR-BI

Class E:

oxLDL

SR-PSOX/ CXCL16

Macrophage representation

Class G:

oxLDL

oxLDL

oxLDL

Class A:

AcLDL

oxLDL

Class F:

Class D:

MEKK2

LYN

oxLDL

JNK

JNK

CD36 CD36

C

N

Foam cell formation

P

Apoptoticcell

S. aureus/lipoteichoic acid

CD36

CN

TSP1

NF-kB

TLR

IRAK

MyD88

Degradation

PhagocytosisTNFα, IL-12, IL-6

2 6

TRAF6

IKK

p50 p65

IκB

CD47α6β1β-amyloidFibrillar ApoC II

CD36

C

N

F-actin

TNFα, IL-1β, MCP1, MIP2,reactivity oxygen species

LYN

p44/42

p44/42

Pax

Pyk2FYN

CAS

P

Scavenger receptors in atherosclerosis

www.abcam.comCopyright © 2008 Abcam. All Rights Reserved. The Abcam logo is a registered trademark.Produced in collaboration with Dr. Kathryn Moore (Harvard University).

Atherosclerosis antibodies from Abcam: See more products at: www.abcam.com/cardiovascular

Product Clonality Applications Host Species DatasheetReactivity www.abcam.com/ab…

Product Clonality Applications Host Species DatasheetReactivity www.abcam.com/ab…

CD47 antibody [B6H12.2] (ab3283)

Clonality Applications Host Species cross reactivityM Flow Cyt, FuncS, ICC, IF, IP Ms Hu

CD47 is expressed on all hematopoietic cells, including leukocytes, platelets and erythrocytes.It is also expressed on epithelial cells, endothelial cells, fibroblasts and many tumor cell lines.This picture shows CD47 staining of human OVCA3 cells using ab3283 at 1 µg/ml.

TLR2 antibody (ab24192)

Clonality Applications Host Species cross reactivityP IHC-P, WB Rb Hu, Ms

TLR2 plays a fundamental role in pathogen recognition and activation of innate immunity. TLR2recognizes pathogen associated molecular patterns (PAMPs) that are expressed on infectiousagents, and mediate the production of cytokines necessary for the development of effectiveimmunity. This picture shows TRL2 staining of human spleen cells using ab24192 at 2 µg/ml.

Apolipoprotein A I P ELISA, IHC-Fr, IHC-P Rb Hu, Mk 14521Apolipoprotein A I [EP1368Y] M ICC/IF, IHC-P, IP, WB Rb Hu 52945Apolipoprotein A II M IHC-P, WB Ms Hu 54796Apolipoprotein A V - Aminoterminal end P ELISA, WB Rb Hu, Ms, Rat 55977Apolipoprotein B P Dot, ELISA, IF, IHC-P, WB Gt Hu, Rb 7616Apolipoprotein B P DID, Ie, IHC-Fr, RID, RIe Sh Hu, Rat, Gpig, Pig 8947Apolipoprotein CI P Dot, ELISA, WB Gt Hu 7617Apolipoprotein CII P Dot, ELISA, IHC-P, WB Gt Hu 7618Apolipoprotein CIII P Dot, ELISA, IHC-P, WB Gt Hu, SHm 7619Apolipoprotein CIV M WB Ms Hu 54804

Apolipoprotein D [36C6] M IHC-P, WB Ms Hu 49447Apolipoprotein E [EP1373Y] M Flow Cyt, IHC-P, IP, WB Rb Hu 51015Apolipoprotein EIII P ELISA, WB Rb Hu 27543Apolipoprotein J P ELISA, ICC/IF, IHC-P, WB Rb Hu, Ms, Rat 69644Apolipoprotein J [CLI-9] M ICC, IHC-Fr, IP, WB Ms Hu 16077Apolipoprotein L 2 P WB Ms Hu 68098Apolipoprotein Lp (a) (Biotin) P ELISA, WB Sh Hu 27631Apolipoprotein M [8F12C6B8] M ELISA, ICC/IF, WB Ms Hu 66379CD36 [FA6-152] M BL, Flow Cyt, IHC-Fr, IP, WB Ms Hu, Rat 17044CD36 [JC63.1] M BL, Flow Cyt Ms Hu, Ms, Rat 23680

CD36 [VM58] M IF, IHC-Fr Ms Hu 8145CD47 [BRIC 126] M Flow Cyt, IHC-Fr, IP, WB Ms Hu, Cow, Dog, Pig, Shp 23814CD47 [MEM-122] M Flow Cyt, IHC-Fr, WB Ms Hu, Mk, NHuPrm, Pig 9089CD68 [ED1] M Flow Cyt, IHC-P, RIA, ICC, WB, IHC-Fr, IP Ms Rat 31630CXCL16 P WB, ELISA Rb Hu 17537ERK1 + ERK2 P WB, IHC-P Rb Hu, Ms, Rat, Cow, Dog 17942Fyn (phospho Y530) P ELISA, WB Rb Hu, Ms 53690Fyn [Y303] M ICC, IHC-P, WB Rb Hu, Ms, Rat 32022HDL P ELISA, WB Ch Hu 15863HDL [1C5] M ELISA, IHC-Fr Ms Hu 34788

HDLBP P WB Rb Hu 54504IkB beta (phospho S23) P ELISA, WB Rb Hu 51142IkB beta (phospho T19) P ELISA, WB Rb Hu 63510IkB beta P Dot, ELISA, IP, WB Rb Hu, Ms, Rat 7547IKK alpha [Y463] M Flow Cyt, ICC, IHC-P, IP, WB Rb Hu, Ms, Rat 32041IKK beta (phospho Y188) P ELISA, IHC-P Rb Hu, Ms, Rat 53694IKK beta (phospho Y199) P ELISA, IHC-P, WB Rb Hu, Ms, Rat 59195IKK beta P ELISA, IHC-P, WB Rb Hu, Ms, Rat 55404IKK gamma P ELISA, IHC-P, WB Rb Hu, Ms 63538Integrin alpha 6 beta 1 [2Q955] M Flow Cyt, ELISA, IHC-Fr Ms Rat 65194

Integrin alpha V beta 3 [BV3] M Flow Cyt, IHC-P, IP, ICC/IF, IHC-Fr Ms Hu, Rat, Chk 7166IRAK P ICC/IF, IP, WB Rb Hu, Ms, Rat 238JNK1 (phospho T183) P ELISA, IHC-P, WB Rb Hu, Ms, Rat 47337JNK1 P EMSA, IHC-Fr, IP, WB Rb Hu, Ms, Rat 7949JNK2 [341P16] M ELISA, WB Ms Hu, Ms, Rat 19337LDL (Copper oxidized) P ELISA, IHC-P Rb Hu 14519LDL (HOCL) P ELISA, IHC-P Rb Hu 14517LDL (MDA oxidized) [3G5] M Flow Cyt, IHC-P, WB Ms Hu 63976LDL [12G10] M Flow Cyt, WB Ms Hu 63960LDL Receptor [EP1553Y] M Flow Cyt, ICC/IF, IHC-P, IP, WB Rb Hu, Ms, Rat 52818

LOX P WB Rb Hu 31238Lyn (phospho Y396) [EP503Y] M Flow Cyt, WB Rb Hu 40660Lyn (phospho Y507) P ELISA, IHC-P, WB Rb Hu, Ms, Rat 53122Lyn P ELISA, IHC-P, WB Rb Hu, Ms, Rat 53141MARCO [PAL-1] M Flow Cyt, IHC-Fr, IP Ms Hm 33453MEKK2 M Flow Cyt, ICC, WB, IHC-P, IP Rb Hu, Ms, Rat 33918MEKK3 [ep599y] M Flow Cyt, ICC/IF, IHC-P, IP, WB Rb Hu, Ms, Rat 40750NFkB p65 (phospho S276) P ELISA, IHC-P, IP, WB Rb Hu, Ms, Rat 30623NFkB p65 P ELISA, ICC/IF, IHC-P, IP, WB Rb Hu, Ms, Rat 31481Pax2 P GSA, IHC-Fr, WB Rb Hu, Ms, Chk, Xl, Zfsh 37129

PAX3 [6288D4a] M Dot, WB Ms Hu 53571PAX4 P ELISA, IHC-P, WB Rb Hu 42450PAX5 [mAbcam52588] M WB Ms Hu 52588PAX6 [PAX5I326] M ELISA, WB Ms Hu 51358PAX7 M IHC-P, WB Ms Hu, Ms 55494PAX8 [PAX8R1] M Dot, Flow Cyt, ICC, IP, WB Ms Hu, Ms, Rat 53490PAX9 [7C2] M IHC-P, IP, WB Rat Hu, Ms 28538PYK2 (phospho Y402) P ICC/IF, IHC-Fr, WB Rb Hu, Ms, Rat, Chk 4800PYK2 (phospho Y580) P ELISA, IHC-P, WB Rb Hu, Ms, Rat 52209PYK2 [YE353] M ICC/IF, IHC-P, IP, WB Rb Hu, Ms, Rat 32571

Scavenger Receptor BI + BII P BL, ICC/IF, IP, WB Rb Ms 36970Scavenging Receptor SR-BI P IP, WB Rb Hu, Ms, Rat, Hm 3Scavenging Receptor SR-BI P IHC-Fr, WB Rb Hu, Ms, Rat, Hm, Mk 396Scavenging Receptor SR-BI P WB Rb Ms, Rat 24603Scavenging Receptor SR-BI P ICC, ICC/IF, WB Gt Ms 36967Scavenging Receptor SR-BI [3D12] M BL, Flow Cyt, IHC-Fr Ms Rat 37231Scavenging Receptor SR-BI [EP1556Y] M ICC, IHC-P, WB Rb Hu, Ms, Rat 52629Scavenging Receptor SR-BII P ICC/IF, IHC-Fr, IHC-P, WB Rb Ms, Rat, Cow, Hm, Mk 114TLR2 [TL2.1] M Flow Cyt, ICC/IF, IHC-Fr, IHC-P, IP, Neut, WB Ms Hu, CynMk, RMk 9100TRAF6 [EP591Y] M Flow Cyt, ICC, IHC-P, IP, WB Rb Hu, Ms, Rat 33915