Oce 7, 2017 Liang Chen, Ph.D. Nanova Biomaterials Inc. Columbia, Missouri, USA Email: chenliang@Nanovamed.com

Nanova Dental Composite Products

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The New Generation of Nanohybrid Universal and Flowable Composites

TM

Strength and Aesthetics in One Composite

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Clinical Challenges

Composites ~6-8 years, short life span

Amalgam 13-20 years

(Images from ADA.org)

Posterior Restoration

A stronger and more durable composite is needed.

0%

10%

20%

30%

40%

50%

60%

High Wear Low

Strength

High

Shrinkage

Excessively

LowViscosity

47% 45%

29% 24%

Problems Observed with Flowable

Clinicians Report Survey in 2013 (n=1579)

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Nanova Solution-Bionanocomposite Technology

Hydroxyapatite Nanofiber Make Existing Nanohybrid Composites Stronger

Boeing 787 Dreamliner Carbon Fiber Composites

1 μm

Why use hydroxyapatite nanofibers?

• Biomaterial - Dentin and enamel contain hydroxyapatite

• Strength - Superior strength improves the strength of dental composites

• Polishability-Much smaller size than microfibers/whiskers

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• Stronger than other leading composite - Dentist can feel

the difference during restoration

• Stand well against bruxing teeth

• Superior handling properties-Non-sticky to the instrument

NovaPro Fill - Strength

FDA Cleared Use:

Direct anterior and posterior restorations, including occlusal surfaces

Splinting

Core build-ups

Indirect restorations, including inlays, onlays, and veneers

60

90

120

150

180Flexural Strength (MPa)

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• Nice chameleon effect while blending with enamel or dentin

• Greater stain resistance • Good shade match with more than 20 Vita shades

available • Nice final finish with higher luster

Color Shift (Delta E value) in Coffee for 24 hours

0

3

6

9

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NovaPro A2 FiltekSupremeUltra A2B

Premise A2 TPHSpectrum

A2

VenusDiamond A2

Class IV restoration with NovaPro Fill A2- Provided by Dr. Fernando Astorga, University Of Colorado

Before After

NovaPro Fill - Aesthetic

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• Low water sorption rate and high double bond conversion-Long-lasting and durable fills

• Good compatibility with existing self-etch and

total-etch bonding systems

Water Sorption (µg/mm-3)

0

10

20

30

40

NovaPro Venus

Diamond

Premise TPH

Spectra

Shofu Filtek

Supreme

Ultra

NovaPro Fill-Stability

Micro-tensile Strength (MPa)

0

30

60

90

0

30

60

90

NovaPro Fill Filtek Supreme

Ultra

Beautifil II

Degree Conversion Rate(%)

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Clinical Cases and Feedback

Class V restoration with NovaPro Fill A2 Provided by a dentist from Saudi Arabia

• Editors’ Choice Award from Dental Advisor

• Exceptional strength • Excellent aesthetic effects

• Non-sticky to the instrument

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Clinical Cases and Feedback-Highly Aesthetic Restoration

Case1

Provided by Dr. Liu Tianshuang in Dalian Dental Hospital of China

Case2

Super thin veneer made by multiple shades of NovaPro Fill

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NovaPro Flow: FDA Cleared Uses

Precise and easy to place

and control

Less shrinkage stress results

in improved marginal

quality

Superior bond strength

Additional Uses

Stronger than other leading

products

Holding shape well and

lack of stickiness

Great color, adaptation,

and stability

Pits and fissure sealant

Direct and indirect restoration repair Minimally invasive restoration

Class I and II Class III and V

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NovaPro Flow-Features

• Precise and easy to place and control

• Minimal Bubble after dispensing - Prevent void and weakness point in the restoration • Lower shrinkage stress - Results in an improved marginal quality • High Strength and excellent shade blocking-Porcelain crown repair • Hold shape well and lack of stickiness

NovaPro Flow

Kerr

3M

Optical images of flowable composites after injection from syringe

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Two Body Wear Test (50K cycles)

Dentsply 3M Nanova

SEM images of flowable composite before and after wear testing

Nanova

3M

Dentsply GC

NovaPro Flow exhibit better performance on wear resistance and polishing retention

S. Nomoto et al. J Dent Res 95 (Spec Iss B): 1354, 2016

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Clinical Cases and Feedback

Porcelain crown repair by NovaPro Flow Provided by Dr. John W. Farah ( Founder of Dental Advisor)

Temporary crown made by NovaPro Flow A2 Provided by Dr. Kyle Lisenby(Columbia, MO)

• Three awards from Dental Advisor

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Questions & Answers