SYNTHESIS OF MINERALOCORTICOID

SecretionHormone Synonym Avg plasma conc.

(μg/dl)Per day secretion (mg)

Aldosterone

--------- 0.006 0.15

Deoxycorticosterone

DOC 0.0006 0.20

Metabolism

pH=1

MECHANISM OF ACTIONGENOMIC ACTIONNONGENOMIC ACTION

ACTIONTubular reabsorption of sodium and excretion

of potassiumECF volume and arterial pressureSkeletal muscle and cadiac muscleECF hydrogen ionSweat glad and salivary glandIntestine

Sweat gland

Regulation of Aldosterone secretion

Renin – Angiotensin system

Relative Potencies of Corticosteroid with CortisolSteroids GC activity MC activity

Cortisol 1 1

Corticosterone 0.3 15

Aldosterone 0.3 3000

Deoxycorticosterone 0.2 100

Cortisone 0.7 0.8

Prednisolone 4 0.8

9α-Fluorocortisol 10 125

Dexamethasone 25 0

ADRENAL ANDROGENS

17 HYDROXY PREGNENOLONE

DHEA

ANDROSTENEDIONE

TESTOSTERONE

CHOLESTEROL

ESTRADIOLE

PREGNENOLONE

Cholesterol Desmolase

17α Hydroxylase

17 , 20 Lyase

3β HSD

Applied Hypoadrenlism , Addison′s disease , Addisonian

CrisisCushing′s syndrome , Cushing′s diseaseConn′s syndromeAdrenogenital syndrome

Pigmentation

Cushing′s syndrome

Adrenogenital syndrome