Interferon-α-2b
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Reactions 1456 - 15 Jun 2013 S Interferon-α-2b Various toxicities: case report A 32-year-old man developed various toxicities while receiving interferon-α-2b for Gorham’s disease complicated with chylothorax. The man received two doses of SC interferon-α-2b 50µg, administered 1 week apart. His condition was subsequently complicated by severe adverse effects, including fever, chills with rigors, tachypnoea, tachycardia, malaise and anorexia [times to reaction onsets and outcomes not clearly stated]. He then experienced fungaemia, nosocomial pneumonia and acute respiratory failure. One month later, his acute critical condition had resolved. He then received interferon-α-2a with gradual titration, and experienced fewer adverse effects [details of adverse effects with interferon-α-2a not stated]. Author comment: "In cases of adverse effects, most of the patients could ultimately tolerate it with gradual titration of [interferon] dose." Liu C-Y, et al. Gorham’s Disease complicated with bilateral chylothorax and successfully treated with Interferon-alpha-2a. Thoracic Cancer 4: 207-211, No. 2, May 2013. Available from: URL: http://dx.doi.org/10.1111/ j.1759-7714.2012.00154.x - Taiwan 803088360 1 Reactions 15 Jun 2013 No. 1456 0114-9954/10/1456-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Interferon-α-2b
Reactions 1456 - 15 Jun 2013
SInterferon-α-2b
Various toxicities: case reportA 32-year-old man developed various toxicities while
receiving interferon-α-2b for Gorham’s disease complicatedwith chylothorax. The man received two doses of SCinterferon-α-2b 50µg, administered 1 week apart. Hiscondition was subsequently complicated by severe adverseeffects, including fever, chills with rigors, tachypnoea,tachycardia, malaise and anorexia [times to reaction onsets andoutcomes not clearly stated]. He then experienced fungaemia,nosocomial pneumonia and acute respiratory failure. Onemonth later, his acute critical condition had resolved. He thenreceived interferon-α-2a with gradual titration, andexperienced fewer adverse effects [details of adverse effectswith interferon-α-2a not stated].
Author comment: "In cases of adverse effects, most of thepatients could ultimately tolerate it with gradual titration of[interferon] dose."Liu C-Y, et al. Gorham’s Disease complicated with bilateral chylothorax andsuccessfully treated with Interferon-alpha-2a. Thoracic Cancer 4: 207-211, No. 2,May 2013. Available from: URL: http://dx.doi.org/10.1111/j.1759-7714.2012.00154.x - Taiwan 803088360
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Reactions 15 Jun 2013 No. 14560114-9954/10/1456-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
