Interferon-β-1b

Reactions 1491, p21-22 - 8 Mar 2014 S Interferon-β-1b Cutaneous and pulmonary sarcoidosis: case report A 33-year-old woman developed cutaneous and pulmonary sarcoidosis while receiving interferon-β-1b [Betaseron]. The woman, who had a history of multiple sclerosis, started receiving interferon-β-1b [dosage and route not stated]. Two- and-a-half years later, she developed painful erythematous lesions on her legs consistent with erythema nodosum. One week later, she developed pain, swelling and erythema of her left breast, chills, dry cough and fever. Upon breast examination, a tender mass measuring 7cm × 7cm was found. Chest CT scan found unilateral hilar adenopathy, and breast sonography revealed an abscess with peripheral fat inflammation. Following drainage, histopathologic examination revealed multiple granulomas composed of histiocytes and infiltration with giant cells, suggesting granulomatous mastitis. Based on the findings of hilar adenopathy, the granuloma in biopsy, and erythema nodosum, she was diagnosed with sarcoidosis. Interferon-β-1b was withdrawn. The woman started receiving glatiramer acetate, and she was treated with prednisolone and indometacin. She improved in 4 weeks. Author comment: "A comprehensive review of the literature revealed that both [interferon]-β and [interferon]-α may induce sarcoidosis." Sahraian MA, et al. Cutaneous and pulmonary sarcoidosis following treatment of multiple sclerosis with interferon-beta-1b: A case report. Journal of Medical Case Reports 7: [4 pages], No. 270, Dec 2013. Available from: URL: http:// doi.org/10.1186/1752-1947-7-270 - Iran 803100258 1 Reactions 8 Mar 2014 No. 1491 0114-9954/14/1491-0001/$14.95 Adis © 2014 Springer International Publishing AG. All rights reserved

Upload
doanthien
Category

Documents
view
212
download
0

Embed Size (px):

Transcript of Interferon-β-1b

Reactions 1491, p21-22 - 8 Mar 2014

SInterferon-β-1b

Cutaneous and pulmonary sarcoidosis: case reportA 33-year-old woman developed cutaneous and pulmonary

sarcoidosis while receiving interferon-β-1b [Betaseron].The woman, who had a history of multiple sclerosis, started

receiving interferon-β-1b [dosage and route not stated]. Two-and-a-half years later, she developed painful erythematouslesions on her legs consistent with erythema nodosum. Oneweek later, she developed pain, swelling and erythema of herleft breast, chills, dry cough and fever. Upon breastexamination, a tender mass measuring 7cm × 7cm was found.Chest CT scan found unilateral hilar adenopathy, and breastsonography revealed an abscess with peripheral fatinflammation. Following drainage, histopathologicexamination revealed multiple granulomas composed ofhistiocytes and infiltration with giant cells, suggestinggranulomatous mastitis. Based on the findings of hilaradenopathy, the granuloma in biopsy, and erythemanodosum, she was diagnosed with sarcoidosis.

Interferon-β-1b was withdrawn. The woman startedreceiving glatiramer acetate, and she was treated withprednisolone and indometacin. She improved in 4 weeks.

Author comment: "A comprehensive review of theliterature revealed that both [interferon]-β and [interferon]-αmay induce sarcoidosis."Sahraian MA, et al. Cutaneous and pulmonary sarcoidosis following treatment ofmultiple sclerosis with interferon-beta-1b: A case report. Journal of Medical CaseReports 7: [4 pages], No. 270, Dec 2013. Available from: URL: http://doi.org/10.1186/1752-1947-7-270 - Iran 803100258