Interferon-β-1a
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Reactions 1080 - 3 Dec 2005 ★ Interferon-β-1a First report of systemic lupus erythematosus: case report Approximately 32 months after starting interferon-β-1a 12MU twice weekly for multiple sclerosis, a 47-year-old woman developed malaise, arthralgia, muscle pain and oral ulcers. She received corticosteroids and her symptoms resolved. Six weeks later, malaise recurred, with arthritis in her wrists, feet and ankles, and she reported thoracic pleuritic pain. Examination showed joint swelling. Laboratory investigations showed moderate lymphopenia, positive antinuclear antibodies and detection of antihistone antibodies. She was diagnosed with drug-induced systemic lupus erythematosus. Interferon-β-1a was discontinued and her symptoms resolved. She remained well at last followup. Author comment: "The temporal relationship grants IFN-β a causal role in the triggering of the syndrome." Crisp ´ ın JC, et al. Systemic lupus erythematosus induced by therapy with interferon-beta in a patient with multiple sclerosis. Lupus 14: 495-496, No. 6, 2005 - Mexico 801024330 » Editorial comment: A search of AdisBase and Medline did not reveal any previous case reports of systemic lupus erythematosus associated with interferon-β-1a. The WHO Adverse Drug Reactions database contained two reports of LE syndrome associated with interferon-β-1a. 1 Reactions 3 Dec 2005 No. 1080 0114-9954/10/1080-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Interferon-β-1a
Reactions 1080 - 3 Dec 2005
★Interferon-β-1a
First report of systemic lupus erythematosus: casereport
Approximately 32 months after starting interferon-β-1a12MU twice weekly for multiple sclerosis, a 47-year-oldwoman developed malaise, arthralgia, muscle pain and oralulcers. She received corticosteroids and her symptomsresolved. Six weeks later, malaise recurred, with arthritis in herwrists, feet and ankles, and she reported thoracic pleuriticpain. Examination showed joint swelling. Laboratoryinvestigations showed moderate lymphopenia, positiveantinuclear antibodies and detection of antihistone antibodies.She was diagnosed with drug-induced systemic lupuserythematosus. Interferon-β-1a was discontinued and hersymptoms resolved. She remained well at last followup.
Author comment: "The temporal relationship grants IFN-βa causal role in the triggering of the syndrome."Crispı́n JC, et al. Systemic lupus erythematosus induced by therapy withinterferon-beta in a patient with multiple sclerosis. Lupus 14: 495-496, No. 6, 2005- Mexico 801024330
» Editorial comment: A search of AdisBase and Medline didnot reveal any previous case reports of systemic lupuserythematosus associated with interferon-β-1a. The WHOAdverse Drug Reactions database contained two reports of LEsyndrome associated with interferon-β-1a.
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Reactions 3 Dec 2005 No. 10800114-9954/10/1080-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
