Interferon-α
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Reactions 1420 - 22 Sep 2012 S Interferon-α Acquired haemophilia: case report A 58-year-old man developed acquired haemophilia due to to factor VIII inhibitor (FEI) while receiving interferon-α. The man started receiving interferon α [dosage and route not stated] and ribavirin, for hepatitis C infection. He presented to an emergency department 5 weeks later with a haematoma on his right lower extremity, which was swollen, tender and discoloured. Laboratory investigations indicated normal prothrombin time, normal thrombin time and abnormal partial thromboplastin time. Following Bethesda assay, he was diagnosed with acquired haemophilia due to FEIs. interferon-α and ribavirin were discontinued and the man received desmopressin, activated prothrombin complex concentrate and recombinant factor VIIa. He stabilised and was discharged, after which time he received prednisone and cyclophosphamide. Four months later he relapsed and started receiving immunoglobulins. At follow- up 3 years after being diagnosed with acquired haemophilia, he was stable. Author comment: "The uniqueness of this case lies in the development of autoantibodies to factor VIII in a patient without any underlying coagulopathy following treatment with interferon-α for hepatitis C infection, which is an extremely infrequent occurrence." Goyal J, et al. Acquired haemophilia in a patient treated with interferon-alpha for hepatitis C infection. Haemophilia 18: e73-4, No. 3, May 2012. Available from: URL: http://dx.doi.org/10.1111/j.1365-2516.2012.02775.x - USA 803077225 1 Reactions 22 Sep 2012 No. 1420 0114-9954/10/1420-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Interferon-α
Reactions 1420 - 22 Sep 2012
SInterferon-αAcquired haemophilia: case report
A 58-year-old man developed acquired haemophilia dueto to factor VIII inhibitor (FEI) while receiving interferon-α.
The man started receiving interferon α [dosage and routenot stated] and ribavirin, for hepatitis C infection. Hepresented to an emergency department 5 weeks later witha haematoma on his right lower extremity, which wasswollen, tender and discoloured. Laboratory investigationsindicated normal prothrombin time, normal thrombin timeand abnormal partial thromboplastin time. FollowingBethesda assay, he was diagnosed with acquiredhaemophilia due to FEIs.
interferon-α and ribavirin were discontinued and theman received desmopressin, activated prothrombincomplex concentrate and recombinant factor VIIa. Hestabilised and was discharged, after which time he receivedprednisone and cyclophosphamide. Four months later herelapsed and started receiving immunoglobulins. At follow-up 3 years after being diagnosed with acquiredhaemophilia, he was stable.
Author comment: "The uniqueness of this case lies in thedevelopment of autoantibodies to factor VIII in a patientwithout any underlying coagulopathy following treatmentwith interferon-α for hepatitis C infection, which is anextremely infrequent occurrence."Goyal J, et al. Acquired haemophilia in a patient treated with interferon-alpha forhepatitis C infection. Haemophilia 18: e73-4, No. 3, May 2012. Available from:URL: http://dx.doi.org/10.1111/j.1365-2516.2012.02775.x - USA 803077225
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Reactions 22 Sep 2012 No. 14200114-9954/10/1420-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
