Human haemoglobin treats severe sickle-cell anaemia
1
Inpharma 1351 - 17 Aug 2002 ■ A woman with severe sickle-cell anaemia was effectively treated with polymerised human haemoglobin * plus epoetin-α, report investigators from the US. Two days after a left hip replacement, the 40-year-old patient presented with severe generalised pain, shortness of breath, and fever. Her haemoglobin level had dropped to 67g/L, from 85 g/L before the operation. She tested positive for Klebsiella pneumoniae and Escherichia coli, and broad-spectrum antibacterials resolved her fever in 2 days. During 5 days’ administration of matched frozen red blood cells, the patient’s haemoglobin level dropped to 28 g/L. A blood smear indicated reactive haemopoiesis. A delayed haemolytic transfusion reaction was suspected. Polymerised human haemoglobin [‘PolyHeme’] was initiated in combination with SC epoetin-α 40 000 U/day and iron supplementation. The patient’s haemoglobin level increased to 41 g/L after the first administration of human haemoglobin. Treatment for 5 days resulted in a haemoglobin level of 78 g/L and symptomatic improvement. The patient remained well throughout the 4-month follow-up period. * Northfield; phase III for anaemia Raff JP, et al. Transfusion of polymerised human haemoglobin in a patient with severe sickle-cell anaemia. Lancet 360: 464-465, 10 Aug 2002 800901452 1 Inpharma 17 Aug 2002 No. 1351 1173-8324/10/1351-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
-
date post
13-Dec-2016 -
Category
Documents
-
view
212 -
download
0
Transcript of Human haemoglobin treats severe sickle-cell anaemia
Inpharma 1351 - 17 Aug 2002
■ A woman with severe sickle-cell anaemia waseffectively treated with polymerised humanhaemoglobin* plus epoetin-α, report investigatorsfrom the US. Two days after a left hip replacement,the 40-year-old patient presented with severegeneralised pain, shortness of breath, and fever. Herhaemoglobin level had dropped to 67g/L, from 85 g/Lbefore the operation. She tested positive for Klebsiellapneumoniae and Escherichia coli, and broad-spectrumantibacterials resolved her fever in 2 days. During 5days’ administration of matched frozen red bloodcells, the patient’s haemoglobin level dropped to 28g/L. A blood smear indicated reactive haemopoiesis. Adelayed haemolytic transfusion reaction wassuspected. Polymerised human haemoglobin[‘PolyHeme’] was initiated in combination with SCepoetin-α 40 000 U/day and iron supplementation.The patient’s haemoglobin level increased to 41 g/Lafter the first administration of human haemoglobin.Treatment for 5 days resulted in a haemoglobin levelof 78 g/L and symptomatic improvement. The patientremained well throughout the 4-month follow-upperiod.* Northfield; phase III for anaemia
Raff JP, et al. Transfusion of polymerised human haemoglobin in a patientwith severe sickle-cell anaemia. Lancet 360: 464-465, 10 Aug2002 800901452
1
Inpharma 17 Aug 2002 No. 13511173-8324/10/1351-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
