Arotinolol: world first introduction of this α + β-blocker by Sumitomo in Japan

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Arotinolol: world first introduction of this Q + by Sumitomo in Japan Pharmacology Arotinolol. Anon. Drugs of the Future 10: 491. 1985 Antihypertensive effects of arotinolol (S-596) a new adrenergic blocking agen!. in experimental hypertensive rats. Hara T. et al. Folia Pharmacologica Japonica 82: 103. 1983 Effects of a new beta-adrenoceptor blocking agen!. S-596 (Arotinolol). on isolated dog coronary arteries. Sakanashi M. et al. Archives Internationa/es de Pharmacodynamic et de Therapie 263: 208. 1'183 Hemodynamic Effects of Arotinolol in Anesthetized Dogs and its Affinities for Adrenoceptors in Vitro. Hashimoto H. et al. Archives Internationales de Pharmacodynamie et de Therapie 267: 23. 1984 StudIes on concurrent alpha and beta-adrenoceptor blocking action of S-5'16 (Arotinolol). Takekoshi N. et al. Japanese Heart Journal 24: 925-935. 1983 General pharmacological studies on arotinolol (s..596). a beta- adrenoceptor blocking drug. Hara Y. et al. Pharmacometrics 27: 1037. 1984 Possible alpha-adrencoceptor blocking activity of arotinolol (s..596). a new beta-adrenoceptor blocking agent in isolated dog coronary artery. Sakanashi M. et al. Pharmacology 29: 204. 1984 Acute hypotension action of a beta-adrenoceptor blocking agent_ arotinolol in normotensive. OOCA-saline and renal hypertensive rats. Miyano T. et al. Pharmacometrics 28: 307. 1984 Effects of chronic administration of arotinolol (ARL. s..596) on stroke- prone spontaneously hypertensive rats (SHRSP) (I) blood pressure. heart rate and biochemical values. Izumi R. et al. Pharmacometrics 28: 455. 1984 Effects of chronic administration of arotinolol (ARL, s..S96) on stroke- prone spontaneously hypertensive rats (SHRSP) (2) histopathological studies. Sekine I. et al. Pharmacometrics 28: 459. 1984 Effects of chronic administration of arotinolol (ARL. s..596) on stroke- prone spontaneously hypel1ensive rats (SHRSP) (3) studies on catecholamine contents in heart and adrenal gland. Matsuo K. et al. Pharmacometrics 28: 467. 1984 Effects of arotinolol (s..596) on isolated and perfused rat hearts. Sakanashi M. et al. Pharmacometrics 28: 709. 1984 Adrenoceptor blocking effects of arotinolol. a new combined alpha- and beta-adrenoceptor blocking agent. Miyagishi A. et al. Archives Internationales de Pharmacodynamie et de Therapie 271: 249. 1984 Chronic effects of arotinolol (s..596) in spontaneously hypel1ensive rats. Kishi K. et al. Journal of Pharmacobio-Dynamics 8: 50. 1985 Effect of ophthalmic administration of s..596 (arotinolol) on intraocular pressure and haemodynamic in healthy volunteers: Comparison with timolol. Nakashima M. et al. European Journal of Clinical Pharmacology 28: 391. 1985 Alpha-blockade and vasodilation induced by nipradilol. arotinolol and labetalol in pithed rats. Nakagawa Y. et al. The Japanese Journal of Pharmacology 39: 481. 1985 Mechanism of the hypotensive effect of a new B-adrenergic blocking drug. arotinolol (s..596) in anesthetized rabbits. Nakahara H. et al. Archives Internationales de Pharmacodynamie et de Therapie 277: 253. 1985 0156·2703/86/0830-0019/0$01.00/0 © ADIS Press INPHARMA® 30 Aug 1986 19

Transcript of Arotinolol: world first introduction of this α + β-blocker by Sumitomo in Japan

Page 1: Arotinolol: world first introduction of this α + β-blocker by Sumitomo in Japan

Arotinolol: world first introduction of this Q + ~-blocker by Sumitomo in Japan

Pharmacology Arotinolol. Anon. Drugs of the Future 10: 491. 1985 Antihypertensive effects of arotinolol (S-596) a new adrenergic

blocking agen!. in experimental hypertensive rats. Hara T. et al. Folia Pharmacologica Japonica 82: 103. 1983

Effects of a new beta-adrenoceptor blocking agen!. S-596 (Arotinolol). on isolated dog coronary arteries. Sakanashi M. et al. Archives Internationa/es de Pharmacodynamic et de Therapie 263: 208. 1'183

Hemodynamic Effects of Arotinolol in Anesthetized Dogs and its Affinities for Adrenoceptors in Vitro. Hashimoto H. et al. Archives Internationales de Pharmacodynamie et de Therapie 267: 23. 1984

StudIes on concurrent alpha and beta-adrenoceptor blocking action of S-5'16 (Arotinolol). Takekoshi N. et al. Japanese Heart Journal 24: 925-935. 1983

General pharmacological studies on arotinolol (s..596). a beta­adrenoceptor blocking drug. Hara Y. et al. Pharmacometrics 27: 1037. 1984

Possible alpha-adrencoceptor blocking activity of arotinolol (s..596). a new beta-adrenoceptor blocking agent in isolated dog coronary artery. Sakanashi M. et al. Pharmacology 29: 204. 1984

Acute hypotension action of a beta-adrenoceptor blocking agent_ arotinolol in normotensive. OOCA-saline and renal hypertensive rats. Miyano T. et al. Pharmacometrics 28: 307. 1984

Effects of chronic administration of arotinolol (ARL. s..596) on stroke­prone spontaneously hypertensive rats (SHRSP) (I) blood pressure. heart rate and biochemical values. Izumi R. et al. Pharmacometrics 28: 455. 1984

Effects of chronic administration of arotinolol (ARL, s..S96) on stroke­prone spontaneously hypertensive rats (SHRSP) (2) histopathological studies. Sekine I. et al. Pharmacometrics 28: 459. 1984

Effects of chronic administration of arotinolol (ARL. s..596) on stroke­prone spontaneously hypel1ensive rats (SHRSP) (3) studies on catecholamine contents in heart and adrenal gland. Matsuo K. et al. Pharmacometrics 28: 467. 1984

Effects of arotinolol (s..596) on isolated and perfused rat hearts. Sakanashi M. et al. Pharmacometrics 28: 709. 1984

Adrenoceptor blocking effects of arotinolol. a new combined alpha­and beta-adrenoceptor blocking agent. Miyagishi A. et al. Archives Internationales de Pharmacodynamie et de Therapie 271: 249. 1984

Chronic effects of arotinolol (s..596) in spontaneously hypel1ensive rats. Kishi K. et al. Journal of Pharmacobio-Dynamics 8: 50. 1985

Effect of ophthalmic administration of s..596 (arotinolol) on intraocular pressure and haemodynamic in healthy volunteers: Comparison with timolol. Nakashima M. et al. European Journal of Clinical Pharmacology 28: 391. 1985

Alpha-blockade and vasodilation induced by nipradilol. arotinolol and labetalol in pithed rats. Nakagawa Y. et al. The Japanese Journal of Pharmacology 39: 481. 1985

Mechanism of the hypotensive effect of a new B-adrenergic blocking drug. arotinolol (s..596) in anesthetized rabbits. Nakahara H. et al. Archives Internationales de Pharmacodynamie et de Therapie 277: 253. 1985

0156·2703/86/0830-0019/0$01.00/0 © ADIS Press INPHARMA® 30 Aug 1986 19

Electron Observation : Past, Present and Future S.Torii : Waseda University (Japan) Rome PAMELA Workshop 11.05.2009.

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