20131107 presentation short - BINDS · 1865f 2Mendel GJ V¦( g ã®1 Q7 (¿ï 1866f 2 ã®ÊY ý U...

3
ųƆƒƠDNAơĽšŽƝƇŰćř 20131107 İ tRNA ŨƑƆęľŏŔľŎŌƎƋžƃĝƠƤđơ mRNA MJƦXŒŨƑƆęľasĴƦ¸Ä ŖMJľĕŎŐĹŐŞŨƑƆęŗO ŦšŔĹL:ľĸţƠ;ÚÙơ ƠFÏĖYÆÎ}pµ±ĖÆÎėĞü£,|ŹƗŪƃŧOơ ųƆƒŖƥŮ}ŖĖWħIő 10ÌĩŖŽƝƇŰćƠƦđơř ŽƝƇŰć DNA ¼Ċ DNA DNA DNA DNA ƎƋžƃĝĽšŽƝƇŰćř 3UFN Protein Data BankÀĜ¸83UNF ¹ƋƛƀŨżƟƒŖÏđ αƌƘſŰŹ βŷƟƂ ŽƝƇŰćŗŀ ŨƁũƐƅŰžƝŗáÞ°¯×ċŧ§v.Ňţ 20131107 _NĮƉũƟƙƃƜƟŰƪĖÆ 3 h$p://www.tanpaku.org/ Miki Okada7Iwabu et al. Nature. Published online 30 October 2013 ÔµáÞę°¯Ô5ŢďśƓŽƏƘſŰŷƝƃƛƟƒƞÔd»ŖD ŽƝƇŰćŗĿL}ŚőĎĐńŤţ 20131107 _NĮƉũƟƙƃƜƟŰƪĖÆ 4 (¨ßřĎĐńŤţŽƝƇŰć ŧ:|ŇţLơ ¨ß ŵƙŸ ƠÕßPř"¥ńŤţ ŽƝƇŰćŖÔĝĪÑơ http://www.tanpaku.org/

Transcript of 20131107 presentation short - BINDS · 1865f 2Mendel GJ V¦( g ã®1 Q7 (¿ï 1866f 2 ã®ÊY ý U...

Page 1: 20131107 presentation short - BINDS · 1865f 2Mendel GJ V¦( g ã®1 Q7 (¿ï 1866f 2 ã®ÊY ý U ¿ï! m k VÌ Vk Wë Væ Ì VÂæ / D _ VÇ D D _ Væ ç V @ Ù / é V . D Vô =

ųƆƒƠDNAơĽšŽƝƇŰćř�

20131107 �

tRNA�

ŨƑƆęľŏŔľŎŌƎƋžƃĝƠƤ��đơ

mRNA�

MJƦ�XŒŨƑƆęľasĴƦ¸ÄŖMJľĕŎŐĹŐŞŨƑƆęŗOŦšŔĹL:ľĸţƠ;ÚÙ�ơ

ƠFÏĖ�YÆÎ}pµ±Ė�ÆÎėĞ�ü�£,��|ŹƗŪƃŧ�Oơ�

ųƆƒ�Ŗƥ�Ů}��ŖĖ�WħIő�

10�Ìĩ��ŖŽƝƇŰćƠƦ��đơř� ŽƝƇŰć�

DNA

¼Ċ�

DNA

DNA

DNA

DNA

ƎƋžƃĝĽšŽƝƇŰćř�

3UFN Protein Data BankÀĜ¸83UNF �¹ƋƛƀŨżƟƒŖÏ��đį�

αƌƘſŰŹ�βŷƟƂ�

ŽƝƇŰćŗ�ŀ ŨƁũƐƅŰžƝŗáÞ°¯×ċŧ§v.Ňţ�

20131107 _NĮ�ƉũƟƙƃƜƟŰƪĖ�Æ 3

h$p://www.tanpaku.org/� Miki4Okada7Iwabu4et4al.4Nature.(Published4online4304October42013�

Ô�µ↓� áÞę°¯↑� Ô5Ţďś↑�

ƓŽƏƘſŰŷƝƃƛƟƒƞÔd»Ŗ�D�

ŽƝƇŰćŗ�ĿL}ŚőĎĐńŤţ�

20131107 _NĮ�ƉũƟƙƃƜƟŰƪĖ�Æ 4

cß� (¨ßřĎĐńŤţŽƝƇŰćŧ:|ŇţLơ�

¨ß�

c�

ŵƙŸ� ƠÕßPř"¥ńŤţ ŽƝƇŰćŖÔĝ�ĪÑơ�

c�

http://www.tanpaku.org/�

Page 2: 20131107 presentation short - BINDS · 1865f 2Mendel GJ V¦( g ã®1 Q7 (¿ï 1866f 2 ã®ÊY ý U ¿ï! m k VÌ Vk Wë Væ Ì VÂæ / D _ VÇ D D _ Væ ç V @ Ù / é V . D Vô =

ŷƟŲƝŷƝűץ¬«�2001f FĢŴƝżƟŷūƒIJ 2003f Z�öāIJIJIJIJIJIJIJįį9F:ŦʼnţŒį5000��Ĉ 2007f Venterį�ųƆƒįįįįįįįįįįįįįįįįįįįįįįįįįįįįįį100�� 2008f Watson �ųƆƒIJįįįįįįįįįįįįįįįįįįįįįįįįįįįįįį1.5��

Steve Jobs �ųƆƒŒ¾ųƆƒIJIJIJIJIJ 0.1��

20131107 _NĮ�ƉũƟƙƃƜƟŰƪĖ�Æ 5

NHGRI Genome Sequencing Program (GSP)IJhttp://www.genome.gov/sequencingcosts/�

20131107 _NĮ�ƉũƟƙƃƜƟŰƪĖ�Æ 6

ĩģE� ŶƝƋƙ��

�ŨŸŨ� 523�

2ŨŸŨ� 494�

ŨƉƘŮ� 691�

ƖƟƛſƇ4 514�

2Òƞ/Ò� 3554

:ø� 2,5774

ƁƟŽ^ěƠ2013fƦ�³Gơ� 4644Tbytes4

Recent improvements in sequencing technology ("next-gen" sequencing platforms) have sharply reduced the cost of sequencing. The 1000 Genomes Project is the first project to sequence the genomes of a large number of people, to provide a comprehensive resource on human genetic variation.�

4

44Q�ŖųƆƒŧìÍņŌ4

ƁƟŽƍƟŹ4444444!!!!!!!!!!!!!!!!!!

IJIJIJD N AH!

��!

Ơ��150ŶƝƋƙŧ=Ŝơ�

Hindorff LA, MacArthur J (European Bioinformatics Institute), Morales J (European Bioinformatics Institute), Junkins HA, Hall PN, Klemm AK, and Manolio TA. A Catalog of Published Genome-Wide Association Studies. Available at: www.genome.gov/gwastudies. Accessed [2013/11/01]

GWASŖ�Ʃ10�ŖSNPsŒ17ÌĩŖºwŖĠĒ

ƠºwŞï³HŖ�Ìơ�

4

4

4ƁƟŽƍƟŹ4!

ųįƆįƒįįIJIJIJïį³įH!

ųƆƒŧāŜ�

20131107 _NĮ�ƉũƟƙƃƜƟŰƪĖ�Æ 8

ö�Ø�ŧœĺ6Ł�ŝţ�

Page 3: 20131107 presentation short - BINDS · 1865f 2Mendel GJ V¦( g ã®1 Q7 (¿ï 1866f 2 ã®ÊY ý U ¿ï! m k VÌ Vk Wë Væ Ì VÂæ / D _ VÇ D D _ Væ ç V @ Ù / é V . D Vô =

þ[Ė�ŮūƝźƗƟ4h$p://plaza.umin.ac.jp/~GC/�

2005fƧ�Ƥ�Ľšþ[Ė�ŮūƝźƗƟ'hľUŚŢij2013fƥ��­ő138<ľþ[ńŤŐĹţĴ��

þ[Ė�ŮūƝźƗƟŖą�ŧ5oŇţŕŗ�

IJþ[Ė�ŮūƝźƗƟ'hŕŠţþ[ûĭŕ:�ŇţŃŒőij��Ė�ŮūƝźƘƝűY 3Ř��ĩĖ�Y Ŗ�;þ[ŠŢijþ[Ė�ŮūƝźƗƟŖą�ŧ��ńŤţĴ �

6ĭą�ŕŏĹŐ�

IJĖ�ŮūƝźƗƟī|bĞēËŧùÙņŌRYġŧ��ŇţŃŒŕŠŢijþ[Ė�ŮūƝźƗƟþ[ûĭŖ6ĭą�ŧoţŃŒľőĿţĴį bĞÝŖĖ�ŮūƝźƗƟŗƢ IJ��0½Ŗ³LőƢŖ0½n�ÜşŹŽſƉŒƢžƟƒŧÖś1�ņŐŰƗŪŭƝƂŖ&ÃŖŌŝŕ�ŀŃŒľrñőŇƣŊŖŌŝŕƢŚňÐ1ŗƢ0½ŒņŐŖãóľrñőŇƣ0½ŒņŐŖãóŒŗńŚŅŚŔz?ľĸŢƢ^�ŕŗ©īőĿŔĹŒuŦŤŚŇľƢ�ŞR�ŔŃŒŗƢŰƗŪŭƝƂŖŌŝŕŔŢŌĹŒĹĺ�@{őŇƣ+ĻŐĖ�ŮūƝźƘƝűŖLĥőŗQŀŖbad newsŧ~ĹŚŇŖőƢŰƗŪŭƝƂŖxśşèņśŒƢĶŒŞŕGţķŃŒľőĿţqčŖińőŇƣ�

IJ�ŕƢåTŔŴƑƔƄŲƟŷƕƝà*ľ¡ŝšŤŚŇƣ³LőŗŝŝŔŹŽſƉŒžƟƒőĒ�ŧŒŢŚŇƣŊŤŋŤŖŹŽſƉŖl)ŧ´öņƢ1�ŇţŌŝŕŴƑƔƄŲƟŷƕƝŗĤeŕĚñŔąćőŇƣ�

IJńšŕĖ�ŮūƝźƗƟŒĹĺbĞÝŗƢ�ņĹÝÌőŇƣ³GƢŦľFőŗ100<ŧĉŇþ[Ė�ŮūƝźƗƟľÿµņƢ§ČŖLŧmĵŕgłŐĹţ²¤őŇƣŇŔŦōƢ�ņĹÝÌŒņŐŖãóŒƢã"ãčőĖ�ŮūƝźƗƟŒĹĺŞŖŧ�ăņƢĽŏ0½��ŖLőƢþÅŒ§ČŖLŧğ�ŇţƢpathfinderŒņŐŖąćľrñőŇƣ(ŃŖĦijļêŖ SWRYƗŪƉŶŪƝŭƝŹb�Ė�ŮūƝźƘƝűŴƟŹŖWebŶŪƂŠŢơ

20131107 _NĮ�ƉũƟƙƃƜƟŰƪĖ�Æ 9 20131107 _NĮ�ƉũƟƙƃƜƟŰƪĖ�Æ 10

ƈƂųƆƒö�ŕäţĔ�

1865fIJMendel GJ Ė�Ŗ¦(ŧƊƘƔƝã®1 ő7Ĩ¿ï 1866fIJƊƘƔƝã®ÊY ýŕĂ�¿ï

!  ŭƝƃūŖÌŖkƞWëŖæƞÌŖÂæįƞńşŖÇńƞńşŖæƞçŖ

�ŀ�ÙįƞéŖĮńŖôĽšWřŖ�ŦŢ�ŧõ`�

!  ï³kćŗij¨�ŖŠĺŕĖ�±ćª:ņŌØ�őŗŔŀőŗŔŀij

ÓWŖŠĺŔĖ�±ćŖÖś:ŦʼnŒ�C !  �YÁŔŌŝj�ŖÕßYŖ�VĽšŗĶ4µ±ÁķŒ�%ńŤŌ

1900fIJCorrens CE, Tschermak EV & de Vries HM ŊŤŋŤIJ ƓƝƁƙŖ¦( ¿ò

1909fIJJohannsen WL phenotypeƠï³HơŒgenotypeƠĖ�HơŔšŘŕ

gene (Ė�W)ŒĹĺ�tƞ¶ĀŧÛ�

1920fIJWinkler HKA Gene Œįchromosome ŧí:ņŌįgenome ƠųƆƒơŒĹĺ�tƞ¶Āŧ�C�

20131107 _NĮ�ƉũƟƙƃƜƟŰƪĖ�Æ 1/2

ƈƂųƆƒö�ŕäţĔ�

20131107 _NĮ�ƉũƟƙƃƜƟŰƪĖ�Æ 2/2

1900fIJCorrens, Tschermak, IJde VriesIJƓƝƁƙŖ¦( ¿ò 1909fIJJohannsen WL phenotypeƠï³Hơį

genotypeƠĖ�H) geneƠĖ�Wơ

1920fIJWinkler HKA

gene + chromosome ıIJgenomeƠųƆƒơ

IJIJIJĖ�WŖ��ŗŽƝƇŰćŒ IJIJIJÛĻšŤŐĹŌ 1944fIJAvery OT*, MacLeod CM &

McCarty M Ė�WŖ��ŗDNAŒÈB

1952f Hershey AD & Chase M Ė�WŖ��ľDNAő ĸţŒ\ú

IJIJIJIJDNAŖ�đö�ř

*�$Ŗ"Wµ±YÜŖ�

1953fIJWatson JD & Click FHC DNAŖƥĚî��đ�Cį 1962f0Yƞµ´YĆ

IJIJIJIJIJIJIJIJIJIJIJIJIJIJIJIJIJIJIJIJIJIJIJIJIJIJIJIJIJIJIJIJį"Wµ±Y IJIJIJIJIJIJIJ IJIJIJIJIJIJIJIJIJIJIJIJIJ IJIJIJIJIJIJIJIJIJIJIJIJIJIJIJIJIJIJ 1972fIJBerg P �$ŖÖ�ĻDNAÆÎIJ1980f.YĆ�1977fIJGilbert W & Sanger F Ę#¢[¦ƠŶƝůƟ¦ơį1980f.YĆ�1983fIJMullis KBIJƐƘƓƗƟŻĒĝ4sƠPCRơ¦ŧğ¿į1993f.YĆ�1986fIJDulbecco R 1975f0Yƞµ´YĆį "A turning point in cancer research:

Sequencing the human genome” Science 231 (4742) 1987fIJã-ŷƟŲƝŶƟðA.(Applied Biosystems)�1990fIJƈƂųƆƒöāŖFĢø·-Ŀ!Ň�1998fIJVenter JC ƠźƚƗÉơľƈƂųƆƒöāŧï��2001fIJFĢžƟƒŒźƚƗÉųƆƒ�ñĘ#K> IJIJIJIJIJIJƠƈƂĖ�W�Ʀ��Ƨ�ơ�

2003fIJƨŮFĬâƈƂųƆƒöāZ�]÷�2004fIJFĢžƟƒŖZ�öāĂ�¿ï IJIJIJIJIJIJƠƈƂŖĖ�W�ƥ��2.5�ơ�2007fIJVenter JC �ųƆƒ�ğ�2008fIJWatson JD �ųƆƒ�ğ 1000ųƆƒƋƛŸŬŰƂUŚţ IJIJIJIJIJ

yKµ±Y4Ơµ@yKYơ�