1. . 2. -3 1 -6 21. Marik PE, et al. Intensive Care Med. 2008, 34:19801992. Efstathopoulos N, et al. Prostaglandins Leukot. Essent. Fatty Acids 2005, 72:35736 3. -3 , (EPA) 4. 25 , .. 2.6-3.1 Kg 18C - 22C 55% - 65% 5. 10mg EPA 1ml 99% 10mg/ml , = 10 ml 6. 25 mg/ml - 5 mg/ml ( 1-3) - (. 4) ( 5) 1 2 3 4 5 7. (n = 13): (n = 12): (10 mg EPA) : 30 : 10 NaCl 0,9% 10 ml 8. 4 , 15 , ,, 4ml 0 ( ) - 2 - 4 - 24 - 48 14 9. O PMA DHR 513nm FS/SS TNF- L929 10. - - gr 11. 12. pNS 13. pNS 14. pNS 15. ap: 0.047 0. bp: 0.007 0. cp: 0.010 2 48. 16. TNFTNF-- (pg/ml, SE) (h) p0 68.8449.66 182.68111.69 NS2 20.7416.34 21.6211.61 NS4 158.81101.9 157.79117.24 NS24 13.365.24 107.8763.6 NS48 36.7021.70 5.752.57 0.019 17. 18. : , 48h TNF- 48h 19. , , , . 48 , 20. , ,