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1. , , , 2. - . () () 3. , , , . :-International programme on chemical safety (WHO). -FDA. 4. :T .. . . : , . 5. ; (consistency) . . . / . . 6. , , 7. ; , , . . . 8. ; LD50. 50% , . , . 9. . (, ) - (, ). , . ;;;; : , . . . .. , , . 10. . . : tenth-of-a-tenth. 11. no-observed-adverse- effect level (NOAEL) Acceptable Daily Intake (ADI) . . ADI , , .. , . 12. ; European Food Safety Authority (EFSA). W.H.O Food and Agriculture Organization (FAO) JECFA. .. 89/107/EEC. 13. -; .. European Food Safety Authority. (- ) . 14. / - 15. . ( , ) / ( , , . 16. Clostridium botulinum . , . ( ) , . (.. ) . / . : www.who.int/entity/foodsafety. 17. ( 2 ) . :WHO. Fact sheet EURO/02/04 18. (added) (applied) , (.. ) . 19. ; . . . 20. 5000 .: . . 1500 .: . . .. Saffron, paprika, turmeric( . ). 1800: . : 80 , , . . 21. 1900: , (coal- tar colors). , , , . , . 22. 1906: Pure Food and Drugs Act 1938: Federal Food, Drug, and Cosmetic Act 1960: Color additive amendment. (ADI: Acceptable Daily Intake). . 23. 2002 Food Magazine (The Food commission magazine), . 200 . :www.foodcomm.org.uk 24. ( ). 1879. 2 . 300 . 1911 . 1970 . FDA . . 2002. 25. () 1997 .. . , . . 2000 .. . . Ca , , . 26. . 1981. 180 . T 1996 . 100 , , , , , Alzheimer. 27. , - . () , , . 2005 . Joint FAO/WHO Expert Committee on Food Additives (JECFA) .( Geneva, 07-16 June 2005). 28. 1988. 200 . . , 1970, . . 1996 Center for Science in the Public Interest, FDA . , , , . 29. sites www.foodcomm.org.uk www.foodstandards.gov.au www.cspinet.org/reports www.straightforward.se/food_additives www.fda.org www.chewonthis.org.uk www.efet.gr