WHICH βBLOCKERS AFFECT BLOOD SUGAR LEVELS MOST?
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WHICH (J-BLOCKERS AFFECT BLOOD SUGAR LEVELS .MOST? }>ossible interactions between relatively ,l3·blocking drugs and glucose homeostasis are very complex. Data from this double-blind randomised study on 8 healthy males to some extent support R.J. Newman's findings [see Inpharma No 52: pl3 ( 4 Sep 1976).J and suggest that the relatively se lective t3-blocking drugs 'are less likely to produce hypoglycaemia and are therefore potentially safer in diabetics or starvation.' The subjects performed near-maximal exercise for 3 minutes at half -hourly intervals before and for 6 hours after an IV dose of propranolol 0.15 mgjkg, metoprolol 0.3mgjkg, acebutolol 1mgjkg or normal saline. In all cases blood sugar levels fell, recovering after lunch. Acebutolol and metoprolol values closely followed the placebo values, but results for propranolol were lower (not statistically sigiuficant) at 3 and 4 hours after the drug. Metoprolol had the least effect on blood sugar, and propranolol the most, with acebutolol in between. Linton, S.P. et aL: British Medical Journal 2: 877 (9 Oct 1976) INPHARMA23rd October, 1976p14
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Transcript of WHICH βBLOCKERS AFFECT BLOOD SUGAR LEVELS MOST?
WHICH (J-BLOCKERS AFFECT BLOOD SUGAR LEVELS.MOST?
}>ossible interactions between relatively selec~iye an~ non-selecti'!'~ ,l3·blocking drugs and glucose homeostasis are very complex. Data from this double-blind randomised study on 8 healthy males to some extent support R.J. Newman's findings [see Inpharma No 52: pl3 ( 4 Sep 1976).J and suggest that the relatively selective t3-blocking drugs 'are less likely to produce hypoglycaemia and are therefore potentially safer in diabetics or starvation.'
The subjects performed near-maximal exercise for 3 minutes at half-hourly intervals before and for 6 hours after an IV dose of propranolol 0.15 mgjkg, metoprolol 0 .3mgjkg, acebutolol 1 mgjkg or normal saline. In all cases blood sugar levels fell, recovering after lunch. Acebutolol and metoprolol values closely followed the placebo values, but results for propranolol were lower (not statistically sigiuficant) at 3 and 4 hours after the drug. Metoprolol had the least effect on blood sugar, and propranolol the most, with acebutolol in between.
Linton, S.P. et aL: British Medical Journal 2: 877 (9 Oct 1976)
I NPHARMA23rd October, 1976p14
