Lecture 1 The lac operon: essential features of a genetic regulatory
Web viewPRO. genetic engineering:- increase in understanding of nature- new revolution for medicine...
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Transcript of Web viewPRO. genetic engineering:- increase in understanding of nature- new revolution for medicine...
Miriam Litterscheid
Topic: Utopia and dystopia - science and ethics, genetic engineeringText type: newspaper articles, editorials
Utopia/Dystopia
utopia
an ideal community or society
taken from a book by Sir Thomas More, written in 1516
comes from the Greek: οὐ, "not", and τόπος, "place" “nonexistent place”
also refers to human efforts to create a perfect society that does not exist (yet)
global utopia of world peace: seen as one of the possible endings of history after the two world wars
religious utopia: garden of delights; life free of worry
scientific and technological utopia: belief that one day science and technology will allow utopian living standards (absence of death, illness, suffering; changes in human condition)
dystopia
anti-utopia; cacotopia
antithesis of the utopian society
characterized by a totalitarian/authoritarian form of government/some kind of oppressive control
traits of dystopian literature: war, revolution, natural disaster, poor standard of living (only ruling class living in luxury), set in the future
Key terms + explanations
stem cell: cell with the ability to divide for indefinite periods in culture and to give rise to specialized cells
undifferentiated cell: cell that has not yet developed into a specialized cell type
organ transplant: moving an organ from one organism to another
organ donation: the act of giving organs to another person
transhumanism: altering of the human genome to enhance human race
superiority complex: exaggerated feeling of being better than the others
biocentrism: life in the middle of evaluation
human dignity: state of righteousness in human beings
biodiversity: number/variety of organisms (within a geographic region)
chimera: individual composed of a mixture of genetically different cells
omniscience: having total knowledge; knowing everything
omnipotence: having unlimited power; being able to do everything
Genetic engineering
direct manipulation of an organism's genes
uses techniques of molecular cloning and transformation
PRO genetic engineering:- increase in understanding of nature- new revolution for medicine fight against diseasesCON genetic engineering:- not very safe little information- often too expensive
Embryonic Stem Cell Research (ESCR)
embryonic stem cells
derived from embryos
develop from eggs that have been fertilized in an in-vitro fertilization clinic and then donated for research purposes with informed consent of the donors
PRO research:-can differentiate into almost all types of bodily tissue treat diseases- embryo = no human life begins when the brain starts to develop-we will delay treatment if we keep arguing about the question of life - abortion: embryo gets destroyed why not make use of it which could save lives?- divide rapidly offer immediate treatment- solution to infertility problems- embryonic stem cells can be found easily- can be grown relatively easily in culture
CON research:- adult stem cells could be an alternative no killing involved + less money- long promised results have not occurred yet!- taking someone’s life in order to save another one’s is contradictory- embryonic stem cells can be rejected by the body- unknowns tumors could occur
- biocentric position: life stand in the middle of evaluation embryos die- Christian view: life starts with conception embryos = already human
Adult Stem Cell Research (ASCR)
adult stem cells
also known as somatic stem cells somatic = cells of the body (not the germ cells, sperm or eggs)
undifferentiated cells, found among differentiated cells in a tissue or organ that can renew themselves
primary roles of adult stem cells in a living organism: to maintain + repair tissue in which they are found
PRO research:- no killing involved- less money- cannot be rejected as embryonic stem cells can
CON research:- hard to find- might not divide fast enough to offer immediate treatment- are limited to differentiating into different cell types- are rare in mature tissues isolating these cells from an adult tissue is challenging
Cloning
refers to processes used to create copies of DNA fragments (molecular cloning), cells (cell cloning), or organisms
creation of an organism that is an exact genetic copy of another
therapeutic cloning
Somatic Cell Nuclear Transfer (SCNT) / research cloning
embryo’s stem cells are extracted and encouraged to grow into human tissue or human organ for transplant
end result = replacement organ, piece of nerve tissue, or quantity of skin no human being!
destruction of an embryo after stem cells are extracted controversy over morality of procedure
reproductive cloning
intent of creating another organism
genetic material removed from a donor egg result = empty egg
a cell is taken from the organism to be cloned, its nucleus is removed
nucleus is then transferred into empty donor egg
embryo develops
embryo is then transferred into uterus of host organism not allowed yet!
PRO cloning:- treatment of diseases by cloning tissues/organs- pros outweigh the cons with regards to treating diseases- clones don’t have the same personality individuality remains
CON cloning:- no individuality anymore loss of “humanity”/dehumanization- close to “perfectionizing” organisms (e.g. children)- success rate is quite low - therapeutic cloning: stability of the egg with the infused somatic nucleus is poor, requires hundreds of attempts before success is attained embryos die destruction linked to abortion- only God can create life interfering with the progression of nature playing God = hubris- desire for omniscience and omnipotence immoral
Genetically Modified Food (GMF)
foods derived from genetically modified organisms
GM organisms have had specific changes introduced into their DNA by genetic engineering
PRO GM Food:-meets the basic needs of the poor/global need for food- putting an end to hunger- there is more than enough food in the world hunger crisis is caused by problems in food distribution and politics, not production- less costs + lower lever of toxins because of less usage of pesticides- plants can be made resistant to extreme temperatures- can carry less calories, more vitamins and proteins increase in healthiness
CON GM Food:- may cause unknown diseases- widening the gap between rich and poor too expensive for poor/developing countries- biotechnologies have more power- biodiversity gets destroyed/manipulated/lost- promised successes have not been accomplished we should devote our efforts and
money into other solutions- serious health risk: bacteria resistance to antibiotics?- no labeling - cannot solve world hunger problems
Fictitious example – Frankenstein
novel written by Mary Shelley
plot:
scientist, Victor Frankenstein, learns how to create life and creates a being in the likeness of man
created “monster” = Frankenstein = larger than average and more powerful
Frankenstein is treated unequally because of his uniqueness
discussing Frankenstein’s opinions (a few examples)
“Nobody ever needs to die”
one can’t have goals in life if it lasts forever
if you don’t know the pain of losing a beloved person, how are we meant to feel the happiness of being loved?
better to die than to live in pain
life is connected with death/death is the natural way of life
it’s against God’s will which can’t be cheated
“If we can replace one part of the human body, we can replace every part”
single parts are necessary to save lives, but a whole body?
there are enough people in the world
if we replace every part of the body, it will be like creating new human beings
“A dead body still can be brought back to life. It is not immoral to try”
some people want to die/you should be able to decide for yourself
who gives us human beings the right to decide over life/death?
who is responsible for the consequences if it fails?
just the thought it could be successful is immoral
“We can create life to cheat death”
humans can try to save lives, not create it
life and death are no games
life is given by God and death should be too
“We can create a being that is better than us, more intelligent, more civilized”
how can we be perfect when we destroy everything?
only God is omniscient and omnipotent
how can someone “different” be civilized when nobody wants to see anything different?
only a utopian dream
Frankenstein - The Modern Prometheus?
Prometheus (Greek mythology) parallels Victor Frankenstein in many aspects
both rebel against the law of nature
both try to be like God (hubris)
both disregard the limits
Victor Prometheus - is punished by his creature - is punished by Zeus- punishment: suffers the loss of his wife; gets killed by his creature
- punishment: tied up to a rock where his liver gets eaten by an eagle + grows every day pain
- stole the secret of creation from God - stole fire from heaven to give it to man
difference: Frankenstein lets his creature alone not able to understand that he as the creator is the “father”; Prometheus takes care and teachers his creatures
Newspaper articles
quality/posh papers
separate information and opinion
reader can form his/her own view
popular papers
often mix information and opinion
ready-made opinion is offered
news stories
information on current events
deals with matters close to the reader
presents very new or unusual news items
reports about sensational topics
informs about conflicts
only based on facts avoids extra information or writer’s personal opinion
comments
offer view on current issues
editorials- contain comments which are based on a newspaper’s tendency therefore close to the views of the reader
op-eds (opposite editorial/opinion editorial)- give second/different opinions on a subject
columns- short essays on different topics the journalist is free to choose
human interest stories
illustrate general problems
one individual case arousing sympathy (e.g. victims of earthquake)
Possible tasks for analyzing a newspaper article
how does the author try to convince the readers?
stylistic devices
facts
enumeration
exaggeration
rhetorical questions
direct address
irony
allusions
c.f. list of devices on the weblog
function/effect of the headline (+ sometimes also sub-heading)
arouses the reader’s interest
summarizes or tells about the article
often reveals the first critical comment of the author bias?
pro/counter arguments
how does he/she try to appear reliable?
choice of words
scientific vocabulary (adjectives, verbs)
precise definitions
tone?
write a letter to the editor (Leserbrief) or comment on the article
How to write a letter to the editor
upper right corner: your address
below your address: the date
upper left corner: receiver’s address
below receiver’s address: salutation without “dear” (e.g. “Sir or Madam”)
your first sentence mentions the article you’re referring to, the date of publishing and your initial reaction to it
start off by introducing yourself and your position
explain your opinion (argumentative part)
refer to arguments mentioned in the article
end your letter with your name and place of residence only; no complimentary close (i.e. ‘yours sincerely’)
How to comment on the article
mention pro- and counter arguments of the text + develop them further (i.e. discuss them)
comparison with previous knowledge
state your opinion on the topic + support your views with evidence
conclusion: weigh pros and cons