tnf- a (fold change)
description
Transcript of tnf- a (fold change)
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tnf-(fold change)
il-12 (fold change)
ifn-(fold change)
Donor 1
Donor 2
IL-12 (pg/ml)
TNFpg/ml)
IFN (pg/ml)
A D
B E
C F
mR
NA
leve
lsm
RN
A le
vels
mR
NA
leve
ls
Cyt
oki
ne
(p
g/m
l)
Cyt
oki
ne
(p
g/m
l)
Cyt
oki
ne
(p
g/m
l)
Donor 1
Donor 2
Donor 1
Donor 2
Donor 1
Donor 2
Donor 1
Donor 2
Donor 1
Donor 2
Figure S1
Figure S1. Comparative pro-inflammatory transcriptional responses of human PBMCs (2 donors) for reference strains for il-12, ifn-γ and tnf-α (A, B, C) 4 h after stimulation with references and 3 P. freudenreichii strains (MOI of 10) and the corresponding TNFα, IL-12 and IFNγ cytokine responses (D, E, F) at 24 h. Methodology is similar as described for Fig. 1.