T7883 Preparation Instructions Trimethoprim is soluble … Product Number T7883 Storage Temperature...
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Trimethoprim Product Number T7883 Storage Temperature 2-8 °C Product Description Molecular Formula: C 14 H 18 N 4 O 3 Molecular Weight: 290.3 CAS Number: 738-70-5 Melting Point: 199-203 ° C 1 λ max : 271 nm 2 Extinction Coefficient: E mM = 6.31 (0.1 M HCl) pK a = 6.6 1 Trimethoprim is primarily used as an antibacterial agent. It has dihydrofolate reductase inhibitor activity with selectivity for the prokaryote enzyme. 3 The combination of trimethoprim and sulfamethoxazole interferes with the cellular metabolism of folic acid in the bacterial cell by blocking the biosynthesis of nucleotides. Co-trimoxazole is a 5:1 mixture of sulfamethoxazole (Product No. S7507) and trimethoprim. 4 These two antibiotics act synergistically. Trimethoprim lactate (Product No. T0677) is a soluble and stable form of trimethoprim and is widely used. It is much more soluble and stable in solution than trimethoprim (Product No. T7883). Precautions and Disclaimer For Laboratory Use Only. Not for drug, household or other uses. Preparation Instructions Trimethoprim is soluble in water (0.4 mg/ml). It is also soluble in DMSO (50 mg/ml), dimethylacetamide (138.6 mg/ml), benzyl alcohol (72.9 mg/ml), propyleneglycol (25.7 mg/ml), chloroform (18.2 mg/ml), methanol (12.1 mg/ml), ether (0.3 mg/ml), and benzene (0.02 mg/ml). 1 References 1. The Merck Index, 12th Ed., Entry# 9840. 2. J. Med. Chem., 5, 1103 (1962). 3. Schweitzer, B. I., et al., Dihydrofolate Reductase as a Therapeutic Target. FASEB J., 4(8), 2441- 2452 (1990). 4. Martindale The Extra Pharmacopoeia, 30th ed., Reynolds, J. E. F., ed., The Pharmaceutical Press (London, England: 1993), p. 153. ALF/RXR 3/06 Sigma brand products are sold through Sigma-Aldrich, Inc. Sigma-Aldrich, Inc. warrants that its products conform to the information contained in this and other Sigma-Aldrich publications. Purchaser must determine the suitability of the product(s) for their particular use. Additional terms and conditions may apply. Please see reverse side of the invoice or packing slip.
Transcript of T7883 Preparation Instructions Trimethoprim is soluble … Product Number T7883 Storage Temperature...
Trimethoprim Product Number T7883 Storage Temperature 2-8 °C Product Description Molecular Formula: C14H18N4O3 Molecular Weight: 290.3 CAS Number: 738-70-5 Melting Point: 199-203 °C1 λmax: 271 nm2 Extinction Coefficient: EmM = 6.31 (0.1 M HCl) pKa = 6.61 Trimethoprim is primarily used as an antibacterial agent. It has dihydrofolate reductase inhibitor activity with selectivity for the prokaryote enzyme.3 The combination of trimethoprim and sulfamethoxazole interferes with the cellular metabolism of folic acid in the bacterial cell by blocking the biosynthesis of nucleotides. Co-trimoxazole is a 5:1 mixture of sulfamethoxazole (Product No. S7507) and trimethoprim.4 These two antibiotics act synergistically. Trimethoprim lactate (Product No. T0677) is a soluble and stable form of trimethoprim and is widely used. It is much more soluble and stable in solution than trimethoprim (Product No. T7883).
Precautions and Disclaimer For Laboratory Use Only. Not for drug, household or other uses. Preparation Instructions Trimethoprim is soluble in water (0.4 mg/ml). It is also soluble in DMSO (50 mg/ml), dimethylacetamide (138.6 mg/ml), benzyl alcohol (72.9 mg/ml), propyleneglycol (25.7 mg/ml), chloroform (18.2 mg/ml), methanol (12.1 mg/ml), ether (0.3 mg/ml), and benzene (0.02 mg/ml).1 References 1. The Merck Index, 12th Ed., Entry# 9840. 2. J. Med. Chem., 5, 1103 (1962). 3. Schweitzer, B. I., et al., Dihydrofolate Reductase
as a Therapeutic Target. FASEB J., 4(8), 2441-2452 (1990).
4. Martindale The Extra Pharmacopoeia, 30th ed., Reynolds, J. E. F., ed., The Pharmaceutical Press (London, England: 1993), p. 153.
ALF/RXR 3/06
Sigma brand products are sold through Sigma-Aldrich, Inc.Sigma-Aldrich, Inc. warrants that its products conform to the information contained in this and other Sigma-Aldrich publications. Purchaser
must determine the suitability of the product(s) for their particular use. Additional terms and conditions may apply. Please see reverse side ofthe invoice or packing slip.
