Management-of-technology program debuts
1
ORGANIC INTERMEDIATES FROM SWITZERLAND pharmaceuticals agrochemicals dyestuffs flavors fragrances photochemicals Ν - Hydroxyphthalimide O:;NOH ο %iv £3 OH 4-Amino- "Υ~ΝΟ, 3-nitrophenol NH 2 4-Ethylcyclohexanone υ 0 CH2CH3 2,6-Dimethylpiperidine, cis 2,4-Diamino- 1,3,5-trimethyl- benzene (2,4-Diamino- mesitylene) CH ft H,C^ NH 2 NHL 5-Nitroisophthalic acid and derivatives COOH A, Custom synthesis against secrecy agreement Our traditional processes: • nitration • catalytic hydrogénation and other reactions US-Agents: HENLEY CHEMICALS, INC. 50, Chestnut Ridge Road Montvale, NJ 07645 Phone (201)307-0422 FAX (201) 307-0424 ^ — 75 years — R DOTTIKON CH-5605 Dottikon/Switzerland Phone: 057 26 11 55 Telex: 827 923 ssf ch Telefax: 057 24 21 20 CIRCLE 29 ON READER SERVICE CARD 34 January 16, 1989 C&EN Science this loop would straddle the phos- phodiester bond between the β- and γ-phosphates of GTP. This bond is the prime candidate to be the cata- lytic site for GTP hydrolysis in the normal protein. The loss of two hy- drogen bonds may alter the orien- tation of the jS-phosphate group, Kim says, and thus somehow inter- fere with the hydrolytic reaction. Working out the complete mech- anism of loss of GTPase activity will require determination of the struc- ture of native and mutant ras pro- teins bound to GTP. This effort is complicated by the proteins' hydrol- ysis of GTP. Thus the work must be carried out on crystals of the pro- teins bound to GTP analogs that contain a bond between the β- and 7-phosphates that is not susceptible to hydrolysis. Efforts to produce crystals of such complexes are un- der way in Kim's laboratory. The similarity of structures be- tween the mutant and the normal ras proteins may complicate efforts to develop a drug to deactivate the mutant protein and thus halt tumor growth. "The drug must deactivate the mutant form of the protein with- out deactivating the normal protein, which is essential to normal cell growth," Kim points out. "It's going to be a difficult job, but it's theoret- ically possible. Chemists are pretty clever." Rudy Baum EDUCATION Management-of-technology program debuts Satellite broadcasting signals this month are carrying the first courses in a new master of science program initiated by National Technological University in management of tech- nology. NTU plans to have the com- plete two-year program available in June. NTU, based in Fort Collins, Colo., is the first electronic university ded- icated to nationwide satellite broad- casting of graduate-level advanced engineering and technical educa- tion. An accredited, private, non- profit institution founded in 1984, it is a university without a campus or permanent faculty, and is de- signed to serve the advanced edu- cation needs of busy, mobile engi- neers, scientists, and technical man- agers. Ranging from the University of Massachusetts in the Northeast to the University of Arizona in the Southwest, some 28 institutions par- ticipate in the network. So far, NTU's focus has been fair- ly electrical in nature. The new pro- gram brings the number of M.S. programs offered to six. The other five are computer engineering, com- puter science, electrical engineer- ing, engineering management, and manufacturing systems engineering. "Management of technology has been identified as one of the top national priorities, especially in view of the intensity of international com- petition," says Robert W. DeSio, vice president for development and long- range planning for NTU. "Because management of technology is a rel- atively new discipline and interdis- ciplinary in nature, a traditional uni- versity would have difficulty in bringing together the required ed- ucational programs," he adds. NTU is in the second phase of development of the new program. The first phase focused on format and curriculum. Students will be nominated to the program by each of NTU's 60 spon- soring corporations and government agencies. They will be managers who are expected to advance into senior corporate management dur- ing their careers. They will have the financial support of their cor- porations or agencies and will be freed from enough of their regular responsibilities to finish the pro- gram in 24 months. Students will as usual take courses at their work sites through NTU's instructional television network. But in a departure from the format of other NTU programs, they will be brought together during the two- year period for seven one-week in- tense residencies at different par- ticipating university campuses. James Krieger
Transcript of Management-of-technology program debuts
ORGANIC INTERMEDIATES FROM SWITZERLAND
pharmaceuticals agrochemicals dyestuffs
flavors fragrances photochemicals
Ν - Hydroxyphthalimide
O:;NOH ο
%iv £3
OH
4-Amino- " Υ ~ Ν Ο , 3-nitrophenol NH2
4-Ethylcyclohexanone
υ 0 CH2CH3
2,6-Dimethylpiperidine, cis
2,4-Diamino-1,3,5-trimethyl-benzene (2,4-Diamino-mesitylene)
CHft
H , C ^
NH2
NHL
5-Nitroisophthalic acid and derivatives COOH
A, Custom synthesis against secrecy agreement Our traditional processes: • nitration • catalytic hydrogénation and other reactions
US-Agents: HENLEY CHEMICALS, INC. 50, Chestnut Ridge Road Montvale, NJ 07645 Phone (201)307-0422 FAX (201) 307-0424
^ — 75 years —
R DOTTIKON CH-5605 Dottikon/Switzerland Phone: 057 26 11 55 Telex: 827 923 ssf ch Telefax: 057 24 21 20
CIRCLE 29 ON READER SERVICE CARD 34 January 16, 1989 C&EN
Science
this loop would straddle the phos-phodiester bond between the β- and γ-phosphates of GTP. This bond is the prime candidate to be the catalytic site for GTP hydrolysis in the normal protein. The loss of two hydrogen bonds may alter the orientation of the jS-phosphate group, Kim says, and thus somehow interfere with the hydrolytic reaction.
Working out the complete mechanism of loss of GTPase activity will require determination of the structure of native and mutant ras proteins bound to GTP. This effort is complicated by the proteins' hydrolysis of GTP. Thus the work must be carried out on crystals of the proteins bound to GTP analogs that
contain a bond between the β- and 7-phosphates that is not susceptible to hydrolysis. Efforts to produce crystals of such complexes are under way in Kim's laboratory.
The similarity of structures between the mutant and the normal ras proteins may complicate efforts to develop a drug to deactivate the mutant protein and thus halt tumor growth. "The drug must deactivate the mutant form of the protein without deactivating the normal protein, which is essential to normal cell growth," Kim points out. "It's going to be a difficult job, but it's theoretically possible. Chemists are pretty clever."
Rudy Baum
EDUCATION
Management-of-technology program debuts Satellite broadcasting signals this month are carrying the first courses in a new master of science program initiated by National Technological University in management of technology. NTU plans to have the complete two-year program available in June.
NTU, based in Fort Collins, Colo., is the first electronic university dedicated to nationwide satellite broadcasting of graduate-level advanced engineering and technical education. An accredited, private, nonprofit institution founded in 1984, it is a university without a campus or permanent faculty, and is designed to serve the advanced education needs of busy, mobile engineers, scientists, and technical managers. Ranging from the University of Massachusetts in the Northeast to the University of Arizona in the Southwest, some 28 institutions participate in the network.
So far, NTU's focus has been fairly electrical in nature. The new program brings the number of M.S. programs offered to six. The other five are computer engineering, computer science, electrical engineering, engineering management, and manufacturing systems engineering.
"Management of technology has been identified as one of the top national priorities, especially in view
of the intensity of international competition," says Robert W. DeSio, vice president for development and long-range planning for NTU. "Because management of technology is a relatively new discipline and interdisciplinary in nature, a traditional university would have difficulty in bringing together the required educational programs," he adds.
NTU is in the second phase of development of the new program. The first phase focused on format and curriculum.
Students will be nominated to the program by each of NTU's 60 sponsoring corporations and government agencies. They will be managers who are expected to advance into senior corporate management during their careers. They will have the financial support of their corporations or agencies and will be freed from enough of their regular responsibilities to finish the program in 24 months.
Students will as usual take courses at their work sites through NTU's instructional television network. But in a departure from the format of other NTU programs, they will be brought together during the two-year period for seven one-week intense residencies at different participating university campuses.
James Krieger
