LFA-1/ICAM-1 ligation in T-cells influences both Notch and TGF-β pathways Navin K. Verma...

16
LFA-1/ICAM-1 ligation in T-cells influences both Notch and TGF-β pathways Navin K. Verma [email protected]

Transcript of LFA-1/ICAM-1 ligation in T-cells influences both Notch and TGF-β pathways Navin K. Verma...

PowerPoint Presentation

LFA-1/ICAM-1 ligation in T-cells influences both Notch and TGF- pathwaysNavin K. [email protected]

T-cell migration into inflamed tissuesN Engl J Med 1999; 341:1817-28.

T-cell migration in health and diseases

Uncontrolled T-cell traffickingChronic inflammatory diseases

Regulated T-cell migration

Immune response regulations

4Resting T-cellsMigrating T-cellsOng et al, 2014, J Biol Chem; Volkov et al, 2001, Nat ImmunolLFA-1 ICAM-1Laboratory model of T-cell migration

Receptor activation

4

LFA-1/ICAM-1: changes in gene expressionTGF- pathwayNotch pathwayVerma et al. (2012) J Biol ChemLFA-1/ICAM-1 up-regulates both TGF- inhibitory molecules and Notch signalling proteins(verified by RT-qPCR)

TGF- pathwayNotch pathwayVerma et al. (2012) J Biol Chem

Notch Pathway: LFA-1/ICAM-1 activates Notch signallingUnpublished data

pCBF1-Luc reporter123

LFA-1/ICAM-1 activates Notch signalling

NICD

Hey1

Hes1

-TubulinTime on ICAM-1 (h) 0 1 3 6 12Unpublished data3LFA-1 regulates Notch via Akt/ERK/GSK3 signalling axis

10

LFA-1/ICAM-1 favors Notch-dependent Th1 polarization

Unpublished dataNotch Pathway summary

TGF- pathway: LFA-1/ICAM-1 up-regulates TGF- inhibitory molecules

Verma et al. (2012) J Biol Chem

LFA-1/ICAM-1-induced TGF- inhibitory pathway is dependent on STAT3 and/or JNK

Verma et al. (2012) J Biol Chem

LFA-1 stimulated T-cells are refractory to iTreg or Th17 differentiationiTregTh17HumanHumanHumanMouseMouseVerma et al. (2012) J Biol ChemUnpublished illustrationSMAD2SMAD3SMAD2SMAD3PPSMAD2SMAD3PPSMAD4LFA-1TGF-TGF- receptorInhibition of IL-2 secretion, Th17, iTregSTAT3STAT3PPJNKPICAM-1SMAD7SMURF2SKISMAD2SMAD3PPSMAD4SMURF2SKISMAD7STAT3STAT3PPc-Junc-FosAP-1PPLFA-1/ICAM-1 signalling TGF- signallingSummary: LFA-1/ICAM-1 induced TGF- refractoriness in T-cells

Funding supportLaboratory members

NavinFazilSeowCareyMadhaviJianhuiGraceAmuthaPraseetha

Existing collaborations

New collaborations


IMMUNOPHARMACOLOGY (IP) - SBI Congressossbicongressos.com/inflammation2013/resumos/IMMUNOPHARMACOLOGY_IP.pdfa hydrogen sulphide donor reduces acute pancreatitis induced by duct ligation

IMMUNOPHARMACOLOGY (IP) - SBI Congressossbicongressos.com/inflammation2013/resumos/IMMUNOPHARMACOLOGY_IP.pdfa hydrogen sulphide donor reduces acute pancreatitis induced by duct ligation

Fundamentos Te´oricos da Computac¸˜ao - UFMTcomputacao.cua.ufmt.br/~ivairton/courses/lfa/anotacoes.pdf · Fundamentos Te´oricos da Computac¸˜ao IvairtonMonteiroSantos 4deoutubrode2016

Fundamentos Te´oricos da Computac¸˜ao - UFMTcomputacao.cua.ufmt.br/~ivairton/courses/lfa/anotacoes.pdf · Fundamentos Te´oricos da Computac¸˜ao IvairtonMonteiroSantos 4deoutubrode2016

Verma modules for the Virasoro algebra · Representation Theory Future Research Ultimate goal: do the above for more complicated q-deformed Heisenberg-Virasoro algebra. Main problem:

Verma modules for the Virasoro algebra · Representation Theory Future Research Ultimate goal: do the above for more complicated q-deformed Heisenberg-Virasoro algebra. Main problem:

Berberine Prevents Intestinal Mucosal Barrier Damage During … · 2015-01-14 · Key Words: Berberine, Cecal ligation and puncture, Intestinal mucosal barrier, Intra-abdominal infections,

Berberine Prevents Intestinal Mucosal Barrier Damage During … · 2015-01-14 · Key Words: Berberine, Cecal ligation and puncture, Intestinal mucosal barrier, Intra-abdominal infections,

Dr. Antonios G. Kanaras a.kanaras@soton.ac.uk Room 5073 ... · ( ,Angew.Chem.Int.Ed 38,1808) 40 . Chemical ligation of DNA-gold nanoparticles or Splint Complement Jungemann et al.

Dr. Antonios G. Kanaras [email protected] Room 5073 ... · ( ,Angew.Chem.Int.Ed 38,1808) 40 . Chemical ligation of DNA-gold nanoparticles or Splint Complement Jungemann et al.

Rat Immunology - · PDF fileRat Immunology Rat CD2 Other Names: LFA-2, T11 CD2, also known as LFA-2, is a member of the immunoglobulin ... $300 Alexa Fluor® 647 203408 100 μg $225

Rat Immunology - · PDF fileRat Immunology Rat CD2 Other Names: LFA-2, T11 CD2, also known as LFA-2, is a member of the immunoglobulin ... $300 Alexa Fluor® 647 203408 100 μg $225

ICOS ligation recruits the p50 α PI3K regulatory subunit to ...

ICOS ligation recruits the p50 α PI3K regulatory subunit to ...

Supplemental Figure S2. TA cloning test of ZeBaTA-based Agrobacterium tumefaciens binary vector. A, TA cloning test of binary vector pCXUN. (1) Ligation.

Supplemental Figure S2. TA cloning test of ZeBaTA-based Agrobacterium tumefaciens binary vector. A, TA cloning test of binary vector pCXUN. (1) Ligation.

Peptide ligation by chemoselective aminonitrile coupling in ......Our model unites prebiotic aminonitrile synthesis and biological a-peptides, suggesting short N -acyl peptide nitriles

Peptide ligation by chemoselective aminonitrile coupling in ......Our model unites prebiotic aminonitrile synthesis and biological a-peptides, suggesting short N -acyl peptide nitriles

Validated High-Performance Thin-Layer …...2019/10/20  · Jyotsana Dwivedi, Abhishek Gupta, Shikhar Verma, Monika Dwivedi, Sarvesh Paliwal, and Ajay Kumar Singh Rawat* Key Words:

Validated High-Performance Thin-Layer …...2019/10/20  · Jyotsana Dwivedi, Abhishek Gupta, Shikhar Verma, Monika Dwivedi, Sarvesh Paliwal, and Ajay Kumar Singh Rawat* Key Words:

Critical values for 22 discordancy test variants for ...satori.geociencias.unam.mx/23-3/(5)Verma.pdf · 304 Verma and Quiroz-Ruiz by some workers to fi x the limit of 2σ, or more

Critical values for 22 discordancy test variants for ...satori.geociencias.unam.mx/23-3/(5)Verma.pdf · 304 Verma and Quiroz-Ruiz by some workers to fi x the limit of 2σ, or more

CpG ODN ligation of TLR-9 attenuates TNF-α production in untreated active SLE … · Formosan Journal of Rheumatology 2009;23:59-65 60 CpG ligation of TLR-9 and TNF-α in active

CpG ODN ligation of TLR-9 attenuates TNF-α production in untreated active SLE … · Formosan Journal of Rheumatology 2009;23:59-65 60 CpG ligation of TLR-9 and TNF-α in active

Probleme LFA - II - D.C.voinescu

Probleme LFA - II - D.C.voinescu

Linguagens Formais e Aut omatos - uevora.ptvp/lfa/acetatos.pdfAFND M e uma fun˘c~ao de Q em P(Q) de nida por t(qi;a) = [qj2 -fecho(qi) -fecho( (qj;a)) Vasco Pedro, LFA, UE, 2008/2009

Linguagens Formais e Aut omatos - uevora.ptvp/lfa/acetatos.pdfAFND M e uma fun˘c~ao de Q em P(Q) de nida por t(qi;a) = [qj2 -fecho(qi) -fecho( (qj;a)) Vasco Pedro, LFA, UE, 2008/2009

THP/MOM/Ac/Ts ethers and concomitant regioselective ... · Sumit Kumar*, Nishant Verma, Naseem Ahmed* Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee 247

THP/MOM/Ac/Ts ethers and concomitant regioselective ... · Sumit Kumar*, Nishant Verma, Naseem Ahmed* Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee 247

Scholars Research Library Callus production under … production under different culture medium in Pluchea lanceolata : A perennial medicinal plant Aman Verma* and Nidhi Jain School

Scholars Research Library Callus production under … production under different culture medium in Pluchea lanceolata : A perennial medicinal plant Aman Verma* and Nidhi Jain School

Evidence for a differential expression of the Fc … · Ligation of the high-affinity IgE receptor ... interphase and upper part of the Nycoprep were col- ... for up to 8 days with

Evidence for a differential expression of the Fc … · Ligation of the high-affinity IgE receptor ... interphase and upper part of the Nycoprep were col- ... for up to 8 days with

O Macho lfa - meuredator.com.br · Se conquistar é uma arte, logo não significa sermos artistas, não confunda isso, ou todo o seu esforço irá por água abaixo! Você precisa

O Macho lfa - meuredator.com.br · Se conquistar é uma arte, logo não significa sermos artistas, não confunda isso, ou todo o seu esforço irá por água abaixo! Você precisa

Structural basis for specific ligation of the peroxisome ... · In recent years, the critical role of PPAR δ in energy expenditure through its regulation of lipid metabolism, particularly

Structural basis for specific ligation of the peroxisome ... · In recent years, the critical role of PPAR δ in energy expenditure through its regulation of lipid metabolism, particularly

Development of a Scaled Vehicle With Longitudinal Dynamics ...ddv/publications/Scaling2008.pdf · VERMA et al.: DEVELOPMENT OF A SCALED VEHICLE WITH LONGITUDINAL DYNAMICS OF AN HMMWV

Development of a Scaled Vehicle With Longitudinal Dynamics ...ddv/publications/Scaling2008.pdf · VERMA et al.: DEVELOPMENT OF A SCALED VEHICLE WITH LONGITUDINAL DYNAMICS OF AN HMMWV