Interferon-α-2b/ribavirin
1
Reactions 925 - 26 Oct 2002 Interferon-α-2b/ribavirin Bell’s palsy: 2 case reports A 49-year-old man and a 42-year-old woman developed Bell’s palsy during treatment with interferon-α-2b and ribavirin [dosages not stated] for hepatitis C virus infection. The man had been receiving interferon-α-2b and ribavirin for 7.5 weeks when he began to lose muscular tone in his face and forehead. MRI showed mild enhancement of his left facial nerve, consistent with Bell’s palsy. Therapy was discontinued and his symptoms resolved over the following 2 months. Six months later, interferon-α-2b and ribavirin were reinstated for 12 weeks with no recurrence of Bell’s palsy; however, treatment was discontinued due to a lack of viral response. The woman had been receiving interferon-α-2b and ribavirin for 8 weeks when therapy was discontinued due to the development of herpes simplex virus stomatitis and right- sided Bell’s palsy. MRI revealed mild enhancement of her right facial nerve. She was treated with prednisone and her symptoms markedly improved. Hwang I, et al. Bell’s Palsy. A rare complication of interferon therapy for hepatitis C. American Journal of Gastroenterology 97 (Suppl.): 207-208, Sep 2002 [abstract] - USA 800919838 1 Reactions 26 Oct 2002 No. 925 0114-9954/10/0925-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Interferon-α-2b/ribavirin
Reactions 925 - 26 Oct 2002
Interferon-α-2b/ribavirin
Bell’s palsy: 2 case reportsA 49-year-old man and a 42-year-old woman developed
Bell’s palsy during treatment with interferon-α-2b and ribavirin[dosages not stated] for hepatitis C virus infection.
The man had been receiving interferon-α-2b and ribavirinfor 7.5 weeks when he began to lose muscular tone in his faceand forehead. MRI showed mild enhancement of his left facialnerve, consistent with Bell’s palsy. Therapy was discontinuedand his symptoms resolved over the following 2 months. Sixmonths later, interferon-α-2b and ribavirin were reinstated for12 weeks with no recurrence of Bell’s palsy; however,treatment was discontinued due to a lack of viral response.
The woman had been receiving interferon-α-2b and ribavirinfor 8 weeks when therapy was discontinued due to thedevelopment of herpes simplex virus stomatitis and right-sided Bell’s palsy. MRI revealed mild enhancement of her rightfacial nerve. She was treated with prednisone and hersymptoms markedly improved.Hwang I, et al. Bell’s Palsy. A rare complication of interferon therapy for hepatitisC. American Journal of Gastroenterology 97 (Suppl.): 207-208, Sep 2002 [abstract]- USA 800919838
1
Reactions 26 Oct 2002 No. 9250114-9954/10/0925-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
