Blockade of Tim-3 Pathway Ameliorates Interferon-γ Production from ...
Interferon-α
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Reactions 558 - 8 Jul 1995 S Interferon-α Acute pancreatitis in a child: case report Acute pancreatitis occurred in a 9-year-old girl after she was treated with interferon-α for chronic myelogenous leukaemia. The girl was initially treated with SC interferon-α 3 × 10 6 U/day for 2 weeks. Oral hydroxycarbamide was added to this regimen for the following 9 months. She then received interferon-α alone for 3 months. At this time, she noted nausea, abdominal pain and back pain. Her serum amylase level was increased to 7813 IU/L and her serum lipase and elastase levels were increased to 1555 IU/L and 6690 ng/dl, respectively. Interferon-α therapy was discontinued and the girl was treated with gabexate for acute pancreatitis. Her serum amylase, lipase and elastase levels normalised and her symptoms resolved. She continued treatment with hydroxycarbamide therapy alone. Author comment: ‘We believe the acute pancreatitis in this patient was attributable to IFN-α [interferon-α], because 1) this patient had no other potential causes of acute pancreatitis, and 2) there was rapid improvement after discontinuation of drugs.’ Sotomatsu M, et al. Acute pancreatitis associated with interferon-alpha therapy for chronic myelogenous leukemia. American Journal of Hematology 48: 211-212, Mar 1995 - Japan 807072856 1 Reactions 8 Jul 1995 No. 558 0114-9954/10/0558-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Interferon-α
Reactions 558 - 8 Jul 1995
SInterferon-αAcute pancreatitis in a child: case report
Acute pancreatitis occurred in a 9-year-old girl after she wastreated with interferon-α for chronic myelogenous leukaemia.
The girl was initially treated with SC interferon-α 3 × 106
U/day for 2 weeks. Oral hydroxycarbamide was added to thisregimen for the following 9 months. She then receivedinterferon-α alone for 3 months. At this time, she notednausea, abdominal pain and back pain. Her serum amylaselevel was increased to 7813 IU/L and her serum lipase andelastase levels were increased to 1555 IU/L and 6690 ng/dl,respectively.
Interferon-α therapy was discontinued and the girl wastreated with gabexate for acute pancreatitis. Her serumamylase, lipase and elastase levels normalised and hersymptoms resolved. She continued treatment withhydroxycarbamide therapy alone.
Author comment: ‘We believe the acute pancreatitis in thispatient was attributable to IFN-α [interferon-α], because 1) thispatient had no other potential causes of acute pancreatitis, and2) there was rapid improvement after discontinuation of drugs.’Sotomatsu M, et al. Acute pancreatitis associated with interferon-alpha therapy forchronic myelogenous leukemia. American Journal of Hematology 48: 211-212,Mar 1995 - Japan 807072856
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Reactions 8 Jul 1995 No. 5580114-9954/10/0558-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
