Interferon-α
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Reactions 705 - 13 Jun 1998 S Interferon-α Acute renal failure in a patient with nephrotic syndrome: case report A 38-year-old man with nephrotic syndrome secondary to hepatitis B-induced glomerulopathy developed acute renal failure after treatment with interferon-α for his nephrotic syndrome. After receiving 5 doses of SC interferon-α (3MU three times weekly), the man’s serum creatinine level, previously normal, had increased to 213 µmol/L and his urea level was 11.2 mmol/L. He was also experiencing fatigue, dizziness and nausea. Interferon-α therapy was stopped and the man was hospitalised. After 5 days, his serum creatinine level had increased to 1183 µmol/L and his urea level was 37 mmol/L. A diagnosis of acute renal failure secondary to interferon-α was made. The man was treated with bed rest, salt and fluid restriction, furosemide and renal doses of dopamine. Within 3 weeks, his renal function was normal, and remained normal at follow-up 1 month later. Al Harbi A, et al. Interferon-induced acute renal failure in nephrotic syndrome. Nephrology Dialysis Transplantation 13: 1316-1318, May 1998 - Saudi Arabia 800674040 1 Reactions 13 Jun 1998 No. 705 0114-9954/10/0705-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Interferon-α
Reactions 705 - 13 Jun 1998
SInterferon-αAcute renal failure in a patient with nephroticsyndrome: case report
A 38-year-old man with nephrotic syndrome secondary tohepatitis B-induced glomerulopathy developed acute renalfailure after treatment with interferon-α for his nephroticsyndrome.
After receiving 5 doses of SC interferon-α (3MU three timesweekly), the man’s serum creatinine level, previously normal,had increased to 213 µmol/L and his urea level was 11.2mmol/L. He was also experiencing fatigue, dizziness andnausea.
Interferon-α therapy was stopped and the man washospitalised. After 5 days, his serum creatinine level hadincreased to 1183 µmol/L and his urea level was 37 mmol/L. Adiagnosis of acute renal failure secondary to interferon-α wasmade. The man was treated with bed rest, salt and fluidrestriction, furosemide and renal doses of dopamine. Within 3weeks, his renal function was normal, and remained normal atfollow-up 1 month later.Al Harbi A, et al. Interferon-induced acute renal failure in nephrotic syndrome.Nephrology Dialysis Transplantation 13: 1316-1318, May 1998 - SaudiArabia 800674040
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Reactions 13 Jun 1998 No. 7050114-9954/10/0705-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
