(www.pegkaspanagiotis.gr)

.........................................................................................................1 ......................................................................................................................2 .................................................2 LDL ................................................................3 ............................................................................................................4 HDL ...........................................................................................................................5 Lp(a)...........................................................................................................................7 ...................................................................................................7 1.................................................................................................7 /1..............................................................................8 /HDL .....................................................8 ..............................................8 LDL............................................................................................................................8 Non-HDL ..............................................................................................9 / HDL ....................................................................9 ..........................................................9 A ........................................................................................10 ......................................................11 .........................................................................12 E .........................................................................................12 ..................................................................................................................13 ..........................................................20

1

. , HDL. . O "" , . (), . , . HDL . LDL , LDL, IDL ( ) VLDL ( ), , . VLDL . , , , .

2

LDL , LDL . LDL . , . . < 115 155 mg/dl, . , , . , LDL 270 465 mg/dl 465 775 mg/dl. LDL , , , .

3

, , . , , . IDL VLDL VLDL . :

,

, , .

IDL VLDL , HDL . . :

2, , / , , .

> 150 mg/dl , < 150 mg/dl .

4

HDL HDL , . HDL :

, , 2 .

HDL :

2, , .

HDL :

, .

. , . . . HDL ( ), . HDL , 40 mg/dl 45 mg/dl . :

, LDL , ,

5

,

6

.

Lp(a) (a). > 30 mg/dl . LDL, IDL, VLDL . , . LDL . > 150 mg/dl . 1 HDL . , HDL .

7

/1 . /HDL . :

LDL Non-HDL / HDL

LDL Friedewald:

LDL (mg/dl) = . . - HDL - (0,2 ). < 400 mg/dl). , , (VLDL ) , .

8

Non-HDL HDL . LDL, IDL, VLDL . < 400 mg/dl LDL . / HDL > 5 190 250 mg/dl. 10% 27% . , 10% 25% . 40 mg/dl LDL 23% , 19% , 21% . .

9

:

() . , . . H . , :

o () 0.1% - 0.2%,

o 0.2% - 0.3% o 0.3% -

0.5%.

/ . 3% - 5% . (. ) :

o , o , o

. (. ) : HDL,

, , , , .

, .

10

, , . , , . :

, , .

, , , , , .

, , , , , .

. , 200 mg%, , 3 .

11

, . ( ) :

, (

) (, , )

, . , . :

, HDL.

, ( HDL), , LDL. . .

12

:

. :

Cushing :

. . . :

HDL .

:

, , , , .

13

.

, LDL . . :

LDL . . .

. :

, tacrolimus, (, , ), (mibefradil, , ), (itraconazole, ), , (amprenavir, indinavir, nelfinavir,

ritonavir, saquinavir), Sildenafil, , , , .

HDL LDL . HDL , , 2 . , HDL . . , . HDL . , , LDL . , .

14

: LDL 160 mg%, LDL 130 mg%

.

300 mg%, 5.

. , :

,

H . , . , : 1. :

() .

30% . 2. .:

, , , ).

3. , :

, , , , , .

H : 300 mg ,

15

200 mg.

, , . , . , . , :

, , .

:

,

. 1% 2% , 1% HDL 3% - 4% . :

.

(), , . LDL LDL . < 180 mg/dl , .

16

, < 450 mg/dl.

450 900 mg/dl, . , . > 900 mg/dl, . , . : , . , . . , , , . , . . . 1 3 .

17

3 , .

. LDL , , LDL . . . , LDL 40 80 mg/dl. :

< 190 mg/dl

LDL < 119 mg/dl. :

< 175 mg/dl LDL < 100 mg/dl

; , 1 2, , SCORE risk ( , , , , , , , , , , ): SCORE risk > 5 :

< 155 mg/dl LDL < 80 mg/dl < 130 mg/dl

SCORE risk < 5:

SCORE risk. < 5: < 190 mg/dl

18

LDL < 115 mg/dl

19

< 150 mg/dl HDL . HDL < 40 mg/dl , 45 mg/dl > 150 mg/dl . LDL , . . . .

:

1.5 2 . . , :

3 6 .

20