Clonidine hydrochloride (C7897) - Product Information · PDF fileClinical Veterinary...

Clonidine hydrochloride Product Number C 7897 Storage Temperature 2-8 °C Product Description Molecular Formula: C 9 H 9 Cl 2 N 3 • HCl Molecular Weight: 266.6 CAS Number: 4205-91-8 pK a : 8.2 1 Clonidine is an α 2 -adrenergic agonist that has been used clinically as an antihypertensive 3 and an analgesic. 4 It is an inhibitor of gastrointestinal motility that blocks α 2 sites, which leads to an adrenergic response. 2 Clonidine reduces sympathetic stimulation, which leads to lowering of blood pressure and a slowing of heart rate. 5 It has been generally proposed that clonidine and related antihypertensives act through a group of receptors called the imidazoline receptors. 3,6,7,8 Precautions and Disclaimer For Laboratory Use Only. Not for drug, household or other uses. Preparation Instructions Clonidine hydrochloride is soluble in water (50 mg/ml), with heat as needed, yielding a clear to slightly hazy colorless solution. A solution of 50 mg/ml clonidine in water has a pH of 4.0-5.0. It is also soluble in dehydrated alcohol and slightly soluble in chloroform. 7 Storage/Stability Solutions of clonidine may be sterilized by autoclaving. Clonidine should be stored protected from light and in airtight containers. 6 References 1. Clarke’s Isolation and Identification of Drugs, Moffat, A. C. et al., eds, The Pharmaceutical Press (London, GB: 1986), p. 481. 2. Clinical Veterinary Pharmacology, 2nd ed., Upson, D.W., ed., Veterinary Healthcare Communications (Lenexa, KS: 1985), p. 450. 3. Szabo, B., Imidazoline Antihypertensive Drugs: a Critical Review on Their Mechanism of Action. Pharmacol. Ther., 93(1), 1-35 (2002). 4. Boyd, R. E., Alpha2-adrenergic Receptor Agonists as Analgesics. Curr. Top. Med. Chem., 1(3), 193-197 (2001). 5. Martindale The Extra Pharmacopoeia, 30th ed., Reynolds, J. E. F., ed., The Pharmaceutical Press (London, England: 1993), p. 348. 6. Eglen, R. M., et al., Seeing through a glass darkly: Casting Light on Imidazoline ’I’ Sites. Trends Pharmacol. Sci., 19(9), 381-390 (1998). 7. Head, G.A., et al., Relationship Between Imidazoline and Alpha2-adrenoceptors Involved in the Sympatho-inhibitory Actions of Centrally Acting Antihypertensive Agents. J. Auton. Nerv. Syst., 72(2-3),163-9 (1998). 8. Khan, Z. P., et al., Alpha-2 and Imidazoline Receptor Agonists. Their Pharmacology and Therapeutic Role. Anaesthesia, 54(2),146-165 (1999). GCY/RXR 11/02 Sigma brand products are sold through Sigma-Aldrich, Inc. Sigma-Aldrich, Inc. warrants that its products conform to the information contained in this and other Sigma-Aldrich publications. Purchaser must determine the suitability of the product(s) for their particular use. Additional terms and conditions may apply. Please see reverse side of the invoice or packing slip.

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Transcript of Clonidine hydrochloride (C7897) - Product Information · PDF fileClinical Veterinary...

Clonidine hydrochloride

Product Number C 7897Storage Temperature 2-8 °C

Product DescriptionMolecular Formula: C9H9Cl2N3 • HClMolecular Weight: 266.6CAS Number: 4205-91-8pKa: 8.21

Clonidine is an α2-adrenergic agonist that has beenused clinically as an antihypertensive3 and ananalgesic.4 It is an inhibitor of gastrointestinal motilitythat blocks α2 sites, which leads to an adrenergicresponse.2 Clonidine reduces sympathetic stimulation,which leads to lowering of blood pressure and aslowing of heart rate.5 It has been generally proposedthat clonidine and related antihypertensives actthrough a group of receptors called the imidazolinereceptors.3,6,7,8

Precautions and DisclaimerFor Laboratory Use Only. Not for drug, household orother uses.

Preparation InstructionsClonidine hydrochloride is soluble in water (50 mg/ml),with heat as needed, yielding a clear to slightly hazycolorless solution. A solution of 50 mg/ml clonidine inwater has a pH of 4.0-5.0. It is also soluble indehydrated alcohol and slightly soluble in chloroform.7

Storage/StabilitySolutions of clonidine may be sterilized by autoclaving.

Clonidine should be stored protected from light and inairtight containers.6

References1. Clarke’s Isolation and Identification of Drugs,

Moffat, A. C. et al., eds, The Pharmaceutical Press(London, GB: 1986), p. 481.

2. Clinical Veterinary Pharmacology, 2nd ed., Upson,D.W., ed., Veterinary Healthcare Communications(Lenexa, KS: 1985), p. 450.

3. Szabo, B., Imidazoline Antihypertensive Drugs: aCritical Review on Their Mechanism of Action.Pharmacol. Ther., 93(1), 1-35 (2002).

4. Boyd, R. E., Alpha2-adrenergic Receptor Agonistsas Analgesics. Curr. Top. Med. Chem., 1(3),193-197 (2001).

5. Martindale The Extra Pharmacopoeia, 30th ed.,Reynolds, J. E. F., ed., The Pharmaceutical Press(London, England: 1993), p. 348.

6. Eglen, R. M., et al., Seeing through a glass darkly:Casting Light on Imidazoline ’I’ Sites. TrendsPharmacol. Sci., 19(9), 381-390 (1998).

7. Head, G.A., et al., Relationship BetweenImidazoline and Alpha2-adrenoceptors Involved inthe Sympatho-inhibitory Actions of Centrally ActingAntihypertensive Agents. J. Auton. Nerv. Syst.,72(2-3),163-9 (1998).

8. Khan, Z. P., et al., Alpha-2 and ImidazolineReceptor Agonists. Their Pharmacology andTherapeutic Role. Anaesthesia, 54(2),146-165(1999).

GCY/RXR 11/02

Sigma brand products are sold through Sigma-Aldrich, Inc.Sigma-Aldrich, Inc. warrants that its products conform to the information contained in this and other Sigma-Aldrich publications. Purchaser

must determine the suitability of the product(s) for their particular use. Additional terms and conditions may apply. Please see reverse side ofthe invoice or packing slip.